You are here: Home » BioFarma » Research » Public
   
 


 


Descripción
Año
A. Cambon, J. Brea, M. I. Loza, C. Alvarez-Lorenzo, A. Concheiro, S. Barbosa, P. Taboada, V. Mosquera. Cytocompatibility and P-glycoprotein inhibition of block copolymers: structure-activity relationship. Mol. Pharmaceutics (In Press)
2013
Kamal Azzaoui, Edgar Jacoby, Stefan Senger, Emiliano Cuadrado Rodríguez, Mabel Loza, Barbara Zdrazil, Marta Pinto, Antony J. Williams, Victor de la Torre,Jordi Mestres, Manuel Pastor, Olivier Taboureau, Matthias Rarey, Christine Chichester, Steve Petiffer, Niklas Blomberg, Lee Harland, Bryn Williams-Jones, Gerhard F. Ecker. Scientific competency questions as the basis for semantically enriched open pharmacological space development. Drug Discovery Today (In Press)
2013
Parguiña AF, Alonso J, Rosa I, Vélez P, González-López MJ, Guitián E, Ebble JA, Loza MI, García A. A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation. Blood. 2012 ; 120(26):117-26.
2013
Yaziji V, Rodriguez D, Coelho A, García-Mera X, El Maatougui A, Brea J, Loza MI, Gutiérrez-de-Terán H, Sotelo E. Selective and potent adenosine A (3) receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl) acetamide scaffold. Eur J Med Chem. 2012 ; 59C: 235-242.
2013
De las Casas-Engel M, Domínguez-Soto A, Sierra-Filardi E, Bragado R, Nieto C, Puig-Kroger A, Samaniego R, Loza M, Corcuera MT, Gómez-Aguado F, Bustos M, Sánchez-Mateos P, Corbí AL. Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7. J Immunol. 2013 .
2013
Cambón A, Rey-Rico A, Mistry D, Brea J, Loza MI, Attwood D, Barbosa S, Alvarez-Lorenzo C, Concheiro A, Taboada P, Mosquera V. Doxorubicin-loaded micelles of reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) block copolymers as efficient "active" chemotherapeutic agents. Int J Pharm. 2013 Feb 1.
2013
Cambón A, Rey-Rico A, Barbosa S, Soltero JF, Yeates SG, Brea J, Loza MI, Alvarez-Lorenzo C, Concheiro A, Taboada P, Mosquera V. Poly(styrene oxide)-poly(ethylene oxide) block copolymers: From "classical" chemotherapeutic nanocarriers to active cell-response inducers. J Control Release. 2013 Jan 23.
2013
Areias F, Costa M, Castro M, Brea J, Gregori-Puigjané E, Proença MF, Mestres J, Loza MI., New chromene scaffolds for adenosine A(2A) receptors: Synthesis, pharmacology and structure-activity relationships. Eur J Med Chem. 2012 May 14.
2012
Redondo M, Brea J, Perez DI, Soteras I, Val C, Perez C, Morales-García JA, Alonso-Gil S, Paul-Fernandez N, Martin-Alvarez R, Cadavid MI, Loza MI, Perez-Castillo A, Mengod G, Campillo NE, Martinez A, Gil C. ,Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds. J Med Chem. 2012 Apr 12;55(7):3274-84. Epub 2012 Mar 16.
2012
Oyarzun-Ampuero FA, Brea J, Loza MI, Alonso MJ, Torres D. A potential nanomedicine consisting of heparin-loaded polysaccharide nanocarriers for the treatment of asthma. Macromol Biosci. 2012 Feb;12(2):176-83. doi: 10.1002/mabi.201100102. Epub 2011 Nov 23.
2012
Redondo M, Zarruk JG, Ceballos P, Pérez DI, Pérez C, Perez-Castillo A, Moro MA, Brea J, Val C, Cadavid MI, Loza MI, Campillo NE, Martínez A, Gil C. ,Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Eur J Med Chem. 2012 Jan;47(1):175-85. Epub 2011 Nov 4.
2012
Miriam Redondo a, Juan G. Zarruk b, Placido Ceballos a, Daniel I. Pérez a, Concepción Pérez a, Ana Perez-Castillo , María A. Moro , José Brea , Cristina Val , María I. Cadavid , María I. Loza , Nuria E. Campillo , Ana Martínez , Carmen Gil ,Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Eur J Med Chem. 2012 Jan;47(1):175-85. Epub 2011 Nov 4.
2012
Colas E, Muinelo L, Llaurado M, Monge M, Barbazan J, Gonzalez M, Schoumacher M, Alonso L, Pedrola N, Ertekin T, Ruiz A, Castellvi J, Doll A, Gil-Moreno A, Vazquez-Levin M, Lapyckyj L, Lopez-Lopez R, Robine S, Friederich E, Castro M, Reventos J, Vignjevic D, Abal M. ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas. Oncogene , (23 January 2012) | doi:10.1038/onc.2011.632
2012
Costa M, Areias F, Castro M, Brea J, Loza MI, Proença F. Synthesis of novel chromene scaffolds for adenosine receptors. Org Biomol Chem. 2011;9(11):4242-9.
2011
Sussman F, Otero JM, Villaverde MC, Castro M, Domínguez JL, González-Louro L, Estévez RJ, Estévez JC. On a possible neutral charge state for the catalytic dyad in ß-secretase when bound to hydroxyethylene transition state analogue inhibitors. J Med Chem. 2011;54(8):3081-5. 2011
Parguiña AF, Grigorian-Shamagian L, Agra RM, López-Otero D, Rosa I, Alonso J, Teijeira-Fernández E, González-Juanatey JR, García A. (2011) Variations in Platelet Proteins Associated With ST-Elevation Myocardial Infarction: Novel Clues on Pathways Underlying Platelet Activation in Acute Coronary Syndromes. Arterioscler Thromb Vasc Biol. 31:2957-2964. 2011
Varela MJ, Brea J, Loza MI, Maldonado R, Robledo P. Sensitization to MDMA locomotor effects and changes in the functionality of 5-HT2A and D2 receptors in mice .Behavioural Pharmacology: August 2011 - Volume 22 - Issue 4 - p 362–369 doi: 10.1097/FBP.0b013e3283487346 2011
Eastwood P, Esteve C, Gonzalez J, Fonquerna S, Aiguade J, Carranco I, Domenech T, Aparici M, Miralpeix M, Albertí J, Cordoba M, Fernandez R, Pont M, Godessart N, Prats N, Loza MI, Cadavid MI, Nueda A, Vidal B. Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Medicinal Chemistry Letters 2011;2(3):213-218 2011
Yaziji V, Rodríguez D, Gutiérrez deTerán H, Coelho A, Caamaño O, García-Mera X, Brea J, Loza MI, Cadavid MI, Sotelo E. Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 2011;54(2):457-71. 2011
Alvarez-Lorenzo C, Rey-Rico A, Brea J, Loza MI, Concheiro A, Sosnik A. Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: branched versus linear derivatives. Nanomedicine (Lond) 2010;5(9):1371-83. 2011
Giovannoni MP, Vergelli C, Cilibrizzi A, Crocetti L, Biancalani C, Graziano A, Piaz VD, Loza MI, Cadavid MI, Díaz JL, Gavaldà A. Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands. Bioorganic & Medicinal Chemistry 18 (2010) 7890–7899. 2010
Lopez L, Selent J, Ortega R, Masaguer CF, Domínguez E, Areias F, Brea J, Loza MI, Sanz F, Pastor M. Synthesis, 3D-QSAR, and Structural Modeling of Benzolactam Derivatives with Binding Affinity for the D2 and D3 Receptors. ChemMedChem 2010; 5(8):1300-17. 2010
Rodríguez-Borges JE, García-Mera X, Balo MC, Brea J, Caamaño O, Fernández F, López C, Loza MI, Nieto MI. Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists. Bioorg Med Chem 2010 Mar 1;18(5):2001-9. 2010
Varin T, Gutiérrez-de-Terán H, Castro M, Brea J, Fabis F, Dauphin F, Aqvist J, Lepailleur A, Perez P, Burgueño J, Vela JM, Loza MI, Rodrigo J. Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists. Br J Pharmacol. 2010 Mar;159(5):1069-81. 2010
Jenkins L, Brea J, Smith NJ, Hudson BD, Reilly G, Bryant NJ, Castro M, Loza MI, Milligan G. Identification of novel, species selective agonists of the G protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13. Biochem J. 2010 Oct 5. [Epub ahead of print]. 2010
Parguiña AF, Grigorian-Shamajian L, Agra RM, Teijeira-Fernández E, Rosa I, Alonso J, Viñuela-Roldán JE, Seoane A, González-Juanatey JR, García A (2010) Proteins involved in platelet signaling are differentially regulated in Acute Coronary Síndrome: a proteomic study. PLoS ONE 5(10):e13404. 2010
García A, Eiras S, Parguiña AF, Alonso J, Rosa I, Salgado-Somoza A, Rico TY, Teijeira-Fernández E, González-Juanatey JR. (2010) High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation. International Journal of Cardiology 150 (2011) 283–290 2010
García A (2010) Clinical proteomics in platelet research: challenges ahead. Journal of Thrombosis and Haemostasis 8:1784-1785. 2010
González-Juanatey JR, Parguiña AF, Rosa I, Grigorian-Shamagián L, Teijeira-Fernández E, Alonso J, Agra R, García A. (2010) Proteomic analysis of circulating human platelets reveals potential biomarkers in non-ST segment elevation acute coronary syndrome. J Am Coll Cardiol. 55;A112.E1047 (doi:10.1016/S0735-1097(10)61048-0). 2010
Trifirò G, Gambassi G, Sen EF, Caputi AP, Bagnardi V, Brea J, Sturkenboom MC. Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study.Ann Intern Med. 2010;152(7):418-25. 2010
Rodríguez-Borges JE, García-Mera X, Balo MC, Brea J, Caamaño O, Fernández F, López C, Loza MI, Nieto MI. Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists. Bioorg Med Chem. 2010;18(5):2001-9. 2010
Nieto MI, Balo MC, Brea J, Caamaño O, Fernández F, García-Mera X, López C, Loza MI, Rodríguez-Borges JE, Vidal B. Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists. Eur J Med Chem. 2010;45(7):2884-92. 2010
Areias FM, Brea J, Gregori-Puigjané E, Zaki ME, Carvalho MA, Domínguez E, Gutiérrez-de-Terán H, Proença MF, Loza MI, Mestres J. In silico directed chemical probing of the adenosine receptor family.Bioorg Med Chem. 2010;18(9):3043-52. 2010
Brea J, Castro-Palomino J, Yeste S, Cubero E, Párraga A, Domínguez E, Loza MI. Emerging opportunities and concerns for drug discovery at serotonin 5-HT2B receptors. Curr Top Med Chem. 2010;10(5):493-503. 2010
Hierrezuelo J, Manuel López-Romero J, Rico R, Brea J, Isabel Loza M, Cai C, Algarra M. Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. Bioorg Med Chem. 2010;18(6):2081-8. 2010
Laguna R, Cadavid MI, Castro M, Brea JM, Loza MI. La experiencia de 10 años de docencia de la asignatura "Fuentes de Información Farmacológica de Medicamentos" impartida con el método de enseñanza basado en la resolución de problemas. Edusfarm, revista d'educació superior en Farmacia, nº 4 (2009).2009
Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ, Vilardaga JP. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol. 2009 Oct;5(10):734-42. 2009
Yaziji V, Coelho A, El Maatougui A, Brea J, Loza MI, García-Mera X, Sotelo E. Divergent solution-phase síntesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists. J. Com. Chem 2009;11(4):519-22. 2009
Nieto MI, Balo MC, Brea J, Caamaño O, Cadavid MI, Fernández F, Mera XG, López C, Rodríguez-Borges JE. Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists. Bioorg Med Chem. 2009;17(9):3426-32 2009
Fernández F, Caamaño O, Isabel Nieto M, López C, García-Mera X, Stefanachi A, Nicolotti O, Isabel Loza M, Brea J, Esteve C, Segarra V, Vidal B, Carotti A. 1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potente adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships. Bioorg Med Chem. 2009; 15;17(10):3618-29. 2009
Zhubi A, Veldic M, Puri N.V, Kadriu B, Caruncho H, Loza I, Sershen H, Lajtha A, Smith R, Guidotti A, Davis J, Costa E. An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes. Schizophrenia Resarch 2009;111(1-3):115-22. 2009
Senis YA, Antrobus R, Severin S, Parguiña AF, Rosa I, Zitzmann N, Watson SP, García A (2009) Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. Journal of Thrombosis and Haemostasis 7:1718-1726. 2009

Selent J, Bauer-Mehren A, López L, Loza MI, Sanz F, Pastor M. A novel multilevel statistical method for the study of the relationships between multireceptorial binding affinity profiles and in vivo endpoints. Mol Pharmacol 2010: 77(2):149-58

2009
Carro L, Raviña E, Dominguez E, Brea J, Loza MI, F. Masaguer C. Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif. Bioorganic and Medicinal Chemistry Letters 2009;19(21):6059-6062. 2009
Varin T, Brea J, Castro MA, Gutiérrez-de-Terán H, Fabis F, Dauphin F, Loza MI, Rodrigo J. Identification of PHE3697.38 of the human 5-HT7 receptor in interaction with receptor specific antagonists by molecular modelling, site-directed mutagenesis and affinity studies. British Journal of Pharmacology 2009;159(5):1069-1081. 2009
Balo MC, Brea J, Caamaño O, Fernández F, García-Mera X, López C, Loza MI, Nieto MI, Rodríguez-Borges JE. Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfurylxanthines as adenosine receptor antagonists. Bioorg Med Chem. 2009; 17(18):6755-60. 2009
Oyarzun-Ampuero FA, Brea J, Loza MI, Torres D, Alonso MJ. Chitosan-hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma. Int J Pharm 2009; 381(2):122-9. 2009
Yaziji V, Coelho A, El Maatougui A, Brea J, Loza MI, García-Mera X, Sotelo E. Divergent solution-phase síntesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists. J. Comb. Chem. 2009, 11, 519–522. 2009
Gutierrez-de-Teran H, Correia C, Rodriguez D, Carvalho MA, Brea J, Cadavid MI, Loza MI, Proenca MF, Areias F. Identification of Novel Scaffolds from an Original Chemical Library as Potential Antipsychotics. QSAR Comb. Sci. 28, 2009, No. 8, 856 – 860. 2009
Fernández F, Caamaño O, Isabel Nieto M, López C, García-Mera X, Stefanachi A, Nicolotti O, Isabel Loza M, Brea J, Esteve C, Segarra V, Vidal B, Carotti A.> 1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potente adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships. Bioorg Med Chem. 2009; 15;17(10):3618-29. 2009
Zhubi A, Veldic M, Puri N.V, Kadriu B, Caruncho H, Loza I, Sershen H, Lajtha A, Smith R, Guidotti A, Davis J, Costa E. An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes. Schizophrenia Resarch 2009;111(1-3):115-22. 2009
Brea J, Castro M, Giraldo J, Lopez-Gimenez JF, Padin JF, Quintian F, Cadavid MI, Vilaro T, Mengod G, Berg KA, Clarke WP, Vilardaga JP, Milligan G, Loza MI. Evidence for distinct antagonist-revealed functional states of 5-HT2A receptor homodimers. Mol Pharmacol 2009; 75(6):1380-91. 2009
Ortega R, Raviña E, Masaguer CF, Areias F, Brea J, Loza MI, López L, Selent J, Pastor M, Sanz F. Synthesis, Binding Affinity and SAR of New Benzolactam Derivatives as Dopamine D3 Receptor Ligands. Bioorg Med Chem Lett 2009; 15;19(6):1773-8. 2009
Zardaín E, Del Valle MO, Loza MI, García E, Lana A, Markham WA, López ML. Psychosocial and behavioural determinants of the implementation of Pharmaceutical Care in Spain. Pharm World Sci 2009;31(2):174-82. 2009
Narayan R, Gangadharan B, Hantz O, Antrobus R, García A, Dwek RA, Zitzmann N. (2009) Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection. J Proteome Res 8:118-122 2009
Stefanachi A, Nicolotti O, Leonetti F, Cellamare S, Campagna F, Loza MI, Brea JM, Mazza F, Gavuzzo E, Carotti A. 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A(2B) adenosine receptor antagonists: Design, synthesis, structure-affinity and structure-selectivity relationships. Bioorg Med Chem. 2008;16(22):9780-9. 2008
Aranda R, Villalba K, Raviña E, Masaguer CF, Brea J, Areias F, Domínguez E, Selent J, López L, Sanz F, Pastor M, Loza MI. Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics. Journal of Medicinal Chemistry 2008;51(19):6085-94. 2008
Buceta M, Dominguez E, Castro MA, Brea JM, Alvarez D, Barcala J, Valdés L, Alvarez-Calderón P, Domínguez F, Vidal B, Díaz JL, Miralpeix M, Beleta J, Cadavid MI, Loza MI. A new Chemicals tool (C0036E08) supports the role of adenosine A2B receptors in mediating human mast cell activation. Biochemical Pharmacology 2008;76(7):912-21. 2008
Rico-Gómez R, López-Romero JM, Hierrezuelo J, Brea J, Loza MI, Pérez-González M. Synthesis of new mannosyl, galactosyl and glucosyl theophylline nucleosides with potential activity as antagonists of adenosine receptors. DEMA-induced cyclization of glycosylideneiminouracils. Carbohydr Res. 2008;343:855-864. 2008

Stefanachi A, Brea JM, Cadavid MI, Centeno NB, Esteve C, Loza MI, Martinez A, Nieto R, Raviña E, Sanz F, Segarra V, Sotelo E, Vidal B, Carotti A. 1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A(2B) adenosine receptor. Bioorg Med Chem. 2008;16(6):2852-69.

2008
Martínez A, Gutiérrez-de-Terán H, Brea J, Raviña E, Loza MI, Cadavid MI, Sanz F, Vidal B, Segarra V, Sotelo E.Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines. Bioorg Med Chem. 2008. 16(4):2103-13. 2008

Rodrilguez-Borges, Jose E.; Gonclalves, Sofia; do Vale, Maria Luisa; Garcia-Mera, Xerardo; Coelho, Alberto; Sotelo, Eddy. Click Chemistry Approach to Assembly Proline Mimetic Libraries Containing 1,4-Substituted 1,2,3-Triazoles. Journal of Combinatorial Chemistry (2008), 10(3), 372-375.

2008
Hughes JR, Meireles AM, Fisher KH, García A, et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biology, e98. 2008
Pardo M,García A, Antrobus R, Blanco MJ, Dwek RA, Zitzmann N. (2007) Biomarker discovery from uveal melanoma secretomes: identification of gp100 and Cathepsin D in patient serum. Journal of Proteome Research 6:2802-2811. 2007

Senis YA, Tomlinson MG,García A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Zitzmann N, Bicknell R, Frampton J, Authi K, Martin A, Wakelam MJO, Watson SP. (2007) A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein. Molecular & Cellular Proteomics 6:548-564.

2007
Balo C, Lopez C, Brea JM, Fernande F, Caamano O. Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4]Triazolo[1,5-c]quinazolines. Chem Pharm Bull (Tokyo) 2007;55(3):372-5. 2007
Domínguez E, Loza MI, Padín F, Gesteira A, Paz E, Páramo M, Brenlla J, Pumar E, Iglesias F, Cibeira A, Castro M, Caruncho H, Carracedo A, Costas J. Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population. Schizophrenia Research 2007;90(1-3):123-9. 2007

Coelho, Alberto; Crespo, Abel; Biagini, PierFrancesco; Sotelo, Eddy. Synthetic application of polystyrene-supported 1,1,3,3-tetramethylguanidine. Proceedings of the International Electronic Conference on Synthetic Organic Chemistry, 11th, Nov. 1-30 (2007), b002/1-b002/10. CODEN: 69KQXM AN 2008:564786 CAPLUS

2007
Elmaatougi, Abdelaziz; Coelho, Alberto; Yanez, Matilde; Meyers, Caroline; Verhelst, Tom; Fraiz, Nuria; Lemiere, Guy L. F.; Garcia-Mera, Xerardo; Laguna, Reyes; Cano, Ernesto; Maes, Bert U. W.; Sotelo, Eddy. 2-substituted 4-,5- and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1e)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis and SAR studies. Bioorganic & Medicinal Chemistry Letters 18 (2008) 793–797 2007

García A, Senis YA, Antrobus R, Hughes CE, Dwek RA, Watson SP, Zitzmann N. (2006) A global proteomics approach identifies novel phosphorylated signalling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.Proteomics 6:5332-5343.

2006
Suzuki-Inoue K, Fuller GLJ, García A , Eble JA, Pohlmann S, Inoue O, Gartner TK, Hughan SC, Pearce AC, Schweighoffer E, Zitzmann N, Morita T, Tybulewicz VLJ, Ozaki Y, Watson SP. (2006)   A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 107 , 542-549. 2006
Pardo M, García A , Thomas B, Piñeiro A, Akoulitchev A, Dwek RA, Zitzmann N (2006) The characterisation of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and led to the identification of DJ-1 as a potential serum biomarker. International Journal of Cancer 119:1014-1022. 2006
Caruncho HJ, Loza MI. Tendiendo puentes entre la psiquiatria y las neurociencias. Rev. Gal. Psiq. Neuroc.,2006; 5: 7-8. 2006
Padín JF, Rodríguez MA, Domínguez E, Dopeso-Reyes IG; Buceta M; Cano E; Sotelo E, Brea J, Caruncho HJ; Cadavid MI, Castro MA; Loza MI. Parallel regulation by olanzapine of the patterns of expression of 5-ht2a and d3 receptors in rat central nervous system and blood cells. Neuropharmacology 2006;51(4):923-32 . 2006
Brea J, Castro M, Loza MI, Masaguer CF, Ravina E, Dezi C, Pastor M, Sanz F, Cabrero-Castel A, Galan-Rodriguez B, Fernandez-Espejo E, Maldonado R, Robledo P. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine. Neuropharmacology 2006;51(2):251-62. 2006
Esteve C, Nueda A, Diaz JL, Beleta J, Cardenas A, Lozoya E, Cadavid MI, Loza MI, Ryder H, Vidal B. New pyrrolopyrimidin-6-yl benzenesulfonamides: Potent A(2B) adenosine receptor antagonists. Bioorg Med Chem Lett 2006;16(14):3642-5. 2006
Carotti A, Cadavid MI, Centeno NB, Esteve C, Loza MI, Martinez A, Nieto R, Raviña E, Sanz E, Segarra V, Sotelo E, Stefanachi A, Vidal B. Design, synthesis and structure-activity relationships at human A2B adenosine receptor of 1-,3-,8-and 9-substituted-9-deazaxanthines. Journal of Medcinal Chemestry. 2006. 12;49(1):282-99. 2006
García A (2006) Proteome analysis of signalling cascades in human platelets. targetBlood Cells, Molecules & Diseases 36:152-156. 2006
Senis YA, Kim PY, Fuller GLJ, García A , Prabhakar S, Brittan H, Zitzmann N, Warrell DA, Kamiguti AS, Theakston RDG, Nesheim ME, Laing G. (2006) Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara . Biochimica et Biophysica Acta - Proteins and Proteomics 1764:863-871. 2006
Suzuki-Inoue K, Fuller GLJ, García A , Eble JA, Pohlmann S, Inoue O, Gartner TK, Hughan SC, Pearce AC, Schweighoffer E, Zitzmann N, Morita T, Tybulewicz VLJ, Ozaki Y, Watson SP. (2006)   A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 107 , 542-549. 2006

Meyers, Caroline; Rombouts, Geert; Loones, Kristof T. J.; Coelho, Alberto; Maes, Bert U. W. Auto-tandem catalysis: synthesis of substituted 11H-indolo[3,2-c]quinolines via palladium-catalyzed intermolecular C-N and intramolecular C-C bond formation. Advanced Synthesis & Catalysis (2008), 350(3), 465-470. CODEN: ASCAF7 ISSN:1615-4150. AN 2008:517026 CAPLUS

2006

Meyers, Caroline; Yanez, Matilde; Elmaatougi, Abdelaziz; Verhelst, Tom; Coelho, Alberto; Fraiz, Nuria; Lemiere, Guy L. F.; Garcia-Mera, Xerardo; Laguna, Reyes; Cano, Ernesto; Maes, Bert U. W.; Sotelo, Eddy. 2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: Design, synthesis, and SAR studies. Bioorganic & Medicinal Chemistry Letters (2008), 18(2), 793-797. CODEN: BMCLE8 ISSN:0960-894X. CAN 148:355725 AN 2008:85188 CAPLUS

2006

Coelho, Alberto; Ravina, Enrique; Fraiz, Nuria; Yanez, Matilde; Laguna, Reyes; Cano, Ernesto; Sotelo, Eddy. Design, Synthesis, and Structure-Activity Relationships of a Novel Series of 5-Alkylidenepyridazin-3(2H)-ones with a Non-cAMP-Based Antiplatelet Activity. Journal of Medicinal Chemistry (2007), 50(26), 6476-6484. CODEN: JMCMAR ISSN:0022-2623. CAN 148:144716 AN 2007:1374786 CAPLUS

2006

Coelho, Alberto; El-Maatougui, Abdelaziz; Ravina, Enrique; Cavaleiro, Jose A. S.; Silva, Artur M. S. Efficient consecutive alkylation-knoevenagel functionalizations in formyl aza-heterocycles using supported organic bases. Synlett (2006), (19), 3324-3328. CODEN: SYNLES ISSN:0936-5214. CAN 146:358784 AN 2007:120937 CAPLUS

2006
Coelho, Alberto; Sotelo, Eddy. Straightforward Entry to Libraries of Diversely Substituted Azinones by a Consecutive Aza-Michael/Palladium-Catalyzed Functionalization Strategy. Journal of Combinatorial Chemistry (2006), 8(3), 388-400. CODEN: JCCHFF ISSN:1520-4766. CAN 144:488613 AN 2006:274051 CAPLUS 2006
Castro M, Nikolaev VO, Palm D, Lohse MJ, Vilardaga JP. Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci U S A. 2005;102(44):16084-9. 2005
Panjehpour M, Castro M, Klotz KN. Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal. Br J Pharmacol. 2005;145(2):211-8. 2005
Alvarado M, Coelho A, Masaguer CF, Raviña E, Brea J, Padín JF, Loza MI. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics. Bioorganic & Medicinal Chemistry Letters 2005;15(12):3063-6. 2005
Candal EM, Caruncho HJ, Sueiro C, Anadon R, Rodriguez-Moldes I. Reelin expression in the retina and optic tectum of developing common brown trout. Dev Brain Res. 2005; 154: 187-19. 2005
Simmons A, Gangadharan B, Hodges A, Sharrocks K, Prabhakar S, García A , Dwek R, Zitzmann N, McMichael A (2005). Nef mediated lipid raft exclusion of UbcH7 positively regulates T cell signaling. Immunity 23, 621-634. 2005
García A , Watson SP, Dwek RA, Zitzmann N. (2005) Applying proteomics technology to platelet research. Mass Spectrom Rev 24 , 918-930. 2005
Pardo M, García A , Thomas B, Piñeiro A, Akoulitchev A, Dwek RA, Zitzmann N (2005). Proteome analysis of a human uveal melanoma primary cell culture by two-dimensional gel electrophoresis and mass spectrometry. Proteomics 5(18) , 4980-4993 . 2005
García A , Watson SP, Dwek RA, Zitzmann N. (2005) Applying proteomics technology to platelet research. Mass Spectrom Rev 24 , 918-930. 2005

Coelho, Alberto; Sotelo, Eddy. Straightforward three-component palladium-catalysed synthesis of pyridazin-3(2H)-one libraries. Combinatorial Chemistry & High Throughput Screening (2006), 9(1), 15-19. CODEN: CCHSFU ISSN:1386-2073. CAN 146:229283 AN 2006:115344 CAPLUS

2005

Crespo, Abel; Meyers, Caroline; Coelho, Alberto; Yanez, Matilde; Fraiz, Nuria; Sotelo, Eddy; Maes, Bert U. W.; Laguna, Reyes; Cano, Ernesto; Lemiere, Guy L. F.; Ravina, Enrique. Pyridazines part 41: Synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones. Bioorg. Med. Chem. Lett. (2006), 16(4), 1080-1083. CODEN: BMCLE8 ISSN:0960-894X. CAN 144:274239 AN 2006:16518 CAPLUS

2005

Alvarado, Mario; Coelho, Alberto; Masaguer, Christian F.; Ravina, Enrique;Brea, Jose; Padin, J. Fernando; Loza, Maria I. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics. Bioorganic & Medicinal Chemistry Letters (2005), 15(12), 3063-3066. CODEN: BMCLE8 ISSN:0960-894X. CAN 143:193774 AN 2005:511376 CAPLUS

2005

Coelho, Alberto; Novoa, Hector; Peeters, Oswald M.; Blaton, Norbert; Alvarado, Mario; Sotelo, Eddy. Pyridazine derivatives. Part 40: Reactivity of 5-alkynylpyridazin-3(2H)-ones toward hydrochloric acid. Tetrahedron (2005), 61(20), 4785-4791. CODEN: TETRAB ISSN:0040-4020. CAN 143:59918 AN 2005:358533 CAPLUS

2005
Perez-Costas E, Melendez-Ferro M, Perez-Garcia C, Caruncho HJ, Rodicio MC. Reelin immunoreactivity in the adult sea lamprey brain. J Chem Neuroanat 2004; 27: 7-21. 2004
Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proc Natl Acad Sci U S A 2004; 101: 348-35 2004
García A, Zitzmann N, Watson SP (2004) Analyzing the platelet proteome.Seminars in Thrombosis and Hemostasis 30:485-489. 2004
Pardo M, Piñeiro A, de la Fuente M , García A , Sripadi P, Zitzmann N, Dwek RA, Sánchez-Salorio M, Domínguez F, Capeans C (2004) Abnormal cell cycle regulation in primary human uveal melanoma cultures. Journal of Cellular Biochemistry 93 , 708-720. 2004

Garca A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (2004) Differential proteome analysis of TRAP-activated platelets: involvement of Dok-2 and phosphorylation of RGS proteins.Blood 103:2088-2095.

2004

García A, Prabhakar S, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (2004) Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry.Proteomics 4:656-668.

2004

Coelho, Alberto; Sotelo, Eddy. Expanding the Chemical Diversity of Azinone Libraries by A Consecutive Alkylation/Palladium-Catalyzed Functionalization Strategy. Journal of Combinatorial Chemistry (2005), 7(4), 526-529. CODEN: JCCHFF ISSN:1520-4766. CAN 143:97320 AN 2005:401964 CAPLUS

2004
Caruncho HJ, Dopeso-Reyes I, Loza MI, Rodríguez MA. GABA, Reelin, and the neurodevelopmental hypothesis of schizophrenia. Critical ReviewsTM in Neurobiology 2004; 16(1-2):25-32. 2004
García A, Zitzmann N, Watson SP (2004) Analyzing the platelet proteome.Seminars in Thrombosis and Hemostasis 30:485-489. 2004
Carotti A, Stefanachi A, Raviña E, Sotelo E, Loza MI, Cadavid MI, Centeno N, Nicoletti O. 8-Sbustituted-9-deazaxanthines as adenosine receptor ligando: design, síntesis and structure-affinity relationships at A2B. European Journal of Medicinal Chemistry 2004;39(10):879-87. 2004
Bosch MP, Campos F, Niubó I, Rosell G, Díaz JL, Brea JM, Loza MI, Guerrero A. Síntesis and biological activity of new potential agonists for the human adenosine A2A receptor. Journal of Medicinal Chemistry. 2004;47(16):4041-53. 2004
Domínguez E, Padín F, Cadavid MI, Loza MI. Integración del Estudio Farmacogenético y Farmacogenómico de la Esquizofrenia (EFFE) en la Red INBIOMED. Informática y Salud 2004; 46:38-40. 2004
Cordero L, Cadavid MI, Fernández-Llimós F, Díaz C, Sanz F, Loza MI. Continuing education and community pharmacists of Galicia: An opinión study. PWS Pharmacy World & Science 2004; 26 (3): 173-177. 2004
Caro Y, Torrado M, Masaguer CG, Raviña E, Padín F, Brea J, Loza MI. Chemoenzymatic syntesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potencial atypical antipsychotics. Bioorgaic & Medicinal Che mistry Letters 2004;14:585-589. 2004

Coelho, Alberto; Sotelo, Eddy. Expanding the Chemical Diversity of Azinone Libraries by A Consecutive Alkylation/Palladium-Catalyzed Functionalization Strategy. Journal of Combinatorial Chemistry (2005), 7(4), 526-529. CODEN: JCCHFF ISSN:1520-4766. CAN 143:97320 AN 2005:401964 CAPLUS

2004

Coelho, Alberto; Sotelo, Eddy; Novoa, Hector; Peeters, Oswald M.; Blaton, Norbert; Ravina, Enrique. Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalyzed reactions. Tetrahedron (2004), 60(52), 12177-12189. CODEN: TETRAB ISSN:0040-4020. CAN 142:134538 AN 2004:1049059 CAPLUS

2004

Coelho, Alberto; Sotelo, Eddy; Fraiz, Nuria; Yanez, Matilde; Laguna, Reyes; Cano, Ernesto; Ravina, Enrique. Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Bioorganic & Medicinal Chemistry Letters (2004), 14(2), 321-324. CODEN: BMCLE8 ISSN:0960-894X. CAN 140:303616 AN 2003:1001958 CAPLUS

2004
Dong E, Caruncho H, Liu WS, Smalheiser NR, Grayson DR, Costa E, Guidotti A. A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proc Natl Acad Sci U S A 2003; 100: 5479-5484. 2003
Villazón, M, Enguix MJ, Tristán H, Honrubia MA, Brea J, Maayani S, Cadavid MI, Loza MI. Different pharmacological properties of two equipotent antagonists (clozapine and rauwolscine) for 5-HT2B receptors in rat stomach fundus. Biochemical Pharmacology 2003;66(6):927-937. 2003
Enguix MJ, Sánchez L, Villazón M, Brea J, Tristán H, Cadavid MI, Loza MI. Differential regulation of rat peripheral 5-HT2A and 5-HT receptors systems: influence of drug treatment. Naunyn-Schmiedeberg's archives of pharmacology 2003;368(2):79-90. 2003
Orallo F, Garcia-Ferreiro T, Enguix MJ, Tristan H, Fdez-Masaguer C, Raviña E, Cadavid MI, Loza MI. In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known a1-adrenoceptor antagonist. Vascular Pharmacology 2003;40(2):97-108. 2003
Brea J, Christian F, Villazón M, Cadavid MI, Raviña E, Fontaine F, Dezi C, Pastor M, Sanz F, Loza MI. Conformationally constrained butyrophenones as new pharmacological tools to study 5-HT2A and 5-HT2C receptor behaviorus. European Journal of Medicinal Chemistry 2003;38(4):433-440. 2003
González-Gómez JC, Santana L, Uriarte E, Brea J, Villazón, Loza MI, De Luca M, Rivas ME, Montenegro GY, Fontenla JA. New arylpiperazine derivatives with higt affinity for 81A, D2 and 5-HT2A receptors. Bioorganic & Medicinal Chemistry Letters 2003; 13(2):175-178. 2003

Nieto, Rosa Maria; Coelho, Alberto; Martinez, Ana; Stefanachi, Angela; Sotelo, Eddy; Ravina, Enrique. Synthesis of 1-substituted-6-methyluracils. CODEN: CPBTAL ISSN:0009-2363. CAN 140:42127 AN 2003:745710 CAPLUS

2003

Sotelo, Eddy; Coelho, Alberto; Ravina, Enrique. Pyridazine derivatives 32: Stille-based approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones. Chemical & Pharmaceutical Bulletin (2003), 51(4), 427-430. CODEN: CPBTAL ISSN:0009-2363. CAN 139:337933 AN 2003:503050 CAPLUS

2003

Sotelo, Eddy; Coelho, Alberto; Ravina, Enrique. Pyridazines. Part 34: Retro-ene-assisted palladium-catalyzed synthesis of 4,5-disubstituted-3(2H)-pyridazinones. Tetrahedron Letters (2003), 44(24), 4459-4462. CODEN: TELEAY ISSN:0040-4039. CAN 139:230701 AN 2003:384384 CAPLUS

2003

Coelho, Alberto; Sotelo, Eddy; Ravina, Enrique. Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones. Tetrahedron (2003), 59(14), 2477-2484. CODEN: TETRAB ISSN:0040-4020. CAN 139:117379 AN 2003:236126 CAPLUS

2003
Vilardaga JP, Bünemann M, Krasel C, Castro M, Lohse MJ. Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nat Biotechnol. 2003;21(7):807-12. 2002
Castro M, Dicker F, Vilardaga JP, Krasel C, Bernhardt M, Lohse MJ. Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins. Endocrinology. 2002;143(10):3854-65. 2002
Rodriguez MA, Caruncho HJ, Costa E, Pesold C, Liu WS, Guidotti A. In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas. J Comp Neurol 2002; 451: 279-288. 2002
Pastor M, Benedetti P, Carotti A, Carrieri A, Díaz C, Herráiz C, Hölje H-D, Loza MI, Opresa R, Padín F, Pubill F, Sanz F, Stoll F & the LINK3D consortium. Distant collaboration in drug discovery: The LINK3D project. Journal of Computer Aided Molecular Design 2002;16(11):809-818. 2002
Villazón M, Padín JF, Cadavid MI, Enguix M, Tristán H, Orallo F, Loza MI. Functional Characterization of Serotonin Receptors in Rat Isolated Aorta. Biological and Pharmaceutical Bulletin 2002; 25(5):584-590. 2002
Honrubia M, Rodrigo J, Cadavid MI, Calleja JM, Sanz F, Loza MI. .Influence of pH on the binding of diphenylmethylenepiperidines by 5-HT2B receptors in rat stomach fundus. Chemicall & Pharmaceutical Bulletin. 2002;50(3):395-8. 2002
Brea J, Rodrigo J, Carrieri A, Sanz F, Cadavid MI, Enguix M, Villazón M, Mengod G, Caro Y, Massaguer CF, Raviña E, Centeno NB, Carotti A, Loza MI. New serotonina 5-HT2A, 5-HT2B and 5-HT2C receptor antagonists: synthesis, pharmacology, 3D QSAR and molecular modelling of (aminoakyl) benzo and heterocycloalkanones. Journal of Medicinal Chemistry. 2002;45(1):54-71. 2002


Description
Year
Loza M, Brea J. New Approaches Applied to Drug Screening. . In: Loza M, Botana LM (eds).Therapeutic Targets. Modulation, Inhibition, and Activation. Wiley & Sons, USA, 2012. pp. 455 - 477. 2012
García A. Two-dimensional gel electrophoresis: basic principles and application to platelet signaling studies. In: García A, Senis YA (eds). Platelet proteomics: Principles, analysis and applications. Wiley & Sons, USA, 2011. pp. 89-110. 2011
García A, Senis Y, Tomlinson MG, Watson SP. Platelet genomics and proteomics. In: Michelson AD editor. Platelets (second edition). Elsevier/Academic Press, USA, 2007. pp. 99-116. 2007
García A. Two-dimensional gel electrophoresis in platelet proteomics research. In: Sreejayan, Ren eds. Vascular biology protocols. Volume included in the series “Methods in molecular medicine”. Humana Press, USA, 2007. pp. 339-354. 2007
Cadavid MI, Loza MI. Tratamiento de la tos. En: Lopez A, Moreno L, Villagrasa V editores. Manual de Farmacología. Guía para el uso racional del medicamento. Madrid: Elsevier España S.A., 2006. p. 132-142. 2006
Bonis J, Loza MI. Sanz F. La bioinformática como soporte a las nuevas estratégias farmacogenéticas y farmacogenómicas. En: Martín F, López V editores. Informática Biomédica. Madrid: INBIOMED, 2004. p. 247-258. 2004
Loza MI, Echarri E, Cadavid MI, Cordero L, Sanz F. Sistema de Información farmacéutica. En: Belmonte MA, Coltell O, Maojo V, Mateu J, Sanz F editores. Manual de Informática Médica. Barcelona: MRA ediciones, 2003. p. 401-413. 2003
Loza MI, Mengod G, Cadavid MI. Autacaides I. Histamina y antihistamínicos. Serotonina y antiserotonímicos. En: Velasco A, San Román L, Serrano J, Martínez-Sierra R, Cadavid MI editores. Farmacología Fundamental. Madrid: McGraw-Hill Interamericana; 2003. p. 141-166. 2003


Description
Year

Título: 'Deseño, implantación e análise de un modelo para a xestión do seguemento farmacoterapéutico nunha farmacia comunitaria'.
Autor: Belen Cobian.
Director: Jose Manuel Brea Floriani, María Isabel Loza García.

2011
Title: Estudio del ratón heterocigoto reeler como modelo animal in vitro de la esquizofrenia. Caracterización farmacológica de los receptores D2 y 5-HT2A.
Author: María José Varela Liste.
Supervisors: Mª Isabel Loza García, Jose Manuel Brea Floriani.
2011

Title: Study of the expression and functional mechanisms of the extracellular matrix protein, reelin, during prenatal development of the rodent brain.
Author: Iria González-Dopeso Reyes.
Supervisors: Hector Caruncho Michinel , Miguel Angel Rodríguez.

2009
Title: Análisis comparativo de la interacción ligando-receptor entre sistemas nativos y recombinantes: comportamiento conformacional de GPCRs.
Author: Juan Fernando Padín Nogueira.
Supervisors: Mª Isabel Loza García, Mª Isabel Cadavid Torres.
2007

Title: Estudio de la variabilidad genética y de la expresión de los receptores 5-HT2A de serotonina y D3 de dopamina como biomarcadores candidatos en la esquizofrenia.
Author: Eduardo Domínguez Medina.
Supervisors: Mª Isabel Loza García, Ángel Carracedo Álvarez.

2007
Title: Estudio de la señalización intracelular y la regulación de los receptores 5-HT2 de serotonina. Evaluación diferencial para antipsicóticos. Thesis.
Author: José Manuel Brea Floriani.
Supervisors: Mª Isabel Loza García, Mª Isabel Cadavid Torres
2004
Title: Regulación farmacológica de receptores acoplados a proteínas G: aplicación a receptores 5-HT2A, 5-HT2B y A2B.
Author:María Villazón González. Facultad de Farmacia, Universidad de Santiago de Compostela.
Supervisors: Mª Isabel Loza García, Mª Isabel Cadavid Torres
2002


Description
Year
Caruncho HJ, Dopeso-Reyes IG, Loza MI, Rodriguez MA. GABA, reelin and the neurodevelopmental hypothesis of schizophrenia. Crit Rev Neurobiol 2004; 16: 25-32. 2004
Caruncho HJ. Book review: “GABA in the nervous system: the view at 50 years”. Journal of Chemical Neuroanatomy 2003; 24: 77. 2003
Caruncho HJ. Book review: “ Biological Psychiatry” by M.R. Trimble. John Wiley and Sons. Journal of Chemical Neuroanatomy 2002;23:231. 2002

 



Description
Year
Therapeutic Targets. Modulation, Inhibition, and Activation. Luis M. Botana / Mabel Loza. Wiley & Sons, USA 2012
Platelet proteomics: Principles, analysis and applications. Ángel García, Yotis A Senis (eds). Wiley & Sons, USA 2011

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Reitoría da USC
Colexio de San Xerome
Praza do Obradoiro, s/n
15782 Santiago de Compostela
Teléfono: +34 981 56 31 00
Vicerreitoría de Coordinación
do Campus de Lugo
Praza Pío XII, 3
27001 Lugo
Teléfono: +34 982 28 59 00