lipodistrofia

Unidade de Enfermidades Tiroideas e Metabólicas foi creada no ano 2003 polos profesores Lado Abeal
e Araújo Vilar ca intención de afondar, por unha parte, na investigación das alteracións moleculares da patoloxía
tumoral tiroidea e outros síndromes tiroideos emerxentes, e por outra na investigación dos mecanismos moleculares
da resistencia á insulina en diferentes síndromes metabólicos (obesidade, diabete mellitus tipo 2, lipodistrofias).
Esta Unidade de Investigación foi creada baixo os auspicios do Decanato da Facultade de Medicina e dos Servicios
de Endocrinoloxía e Nutrición e Medicina Interna do Hospital Clínico Universitario de Santiago de Compostela.

Araújo-Vilar D, Victoria B, González-Méndez B, Barreiro F, Fernández-Rodríguez B, Cereijo R, Gallego-Escuredo JM, Villarroya F, Pañeda-Menéndez A. Histological and molecular features of lipomatous and non -lipomatous adipose tissue in familial partial lipodystrophy due to LMNA mutations. Clinical Endocrinology 2011 Aug 23. doi: 10.1111/j.1365-2265.2011.04208.x. IF: 3.370

Lado Abeal J, Albero Gamboa R, Araujo Vilar D, Barca Mallo O, Bernabeú Moron I, Calvo MT, Castro Piedras I, Martin Calamata J, Palos Paz F, Peinó R, Peteiro D, Victoria B. Clinical and molecular study of five families with resistance to thyroid hormones. Med Clin (Barc). 2011 Jun 22. [Epub ahead of print]. IF: 1.0

Araujo-Vilar D. Congenital generalized lipodystrophy versus Berardinelli-Seip syndrome. An. Pediatr (Barc.). doi:10.1016/j.anpedi.2010.12.015. IF:0.35

Diego Peteiro-Gonzalez, Beatriz Fernandez-Rodriguez, Jose M Cabezas-Agrícola, David Araujo-Vilar. Severe localized lipoatrophy related to therapy with insulin analogs in type 1a diabetes mellitus. Diabetes Res Clin Pract 2011 Mar;91(3):e61-3. IF: 2.16

Berta Victoria, Marta Cuervo, José Manuel Cabezas-Agrícola, Blanca González-Méndez, Giovanna Lattanzi, Rosalba Del Coco, Lourdes Loidi, Francisco Barreiro, Carlos Calvo, David Araújo-Vilar.Reduced adipogenic gene expression in fibroblasts from a patient with type 2 congenital generalized lipodystrophy Diabetic Medicine 2010, 27: 1178–1187. IF: 2.871

Joaquin Lado-Abeal, Rosa-Maria Calvo, Berta Victoria, Isabel Castro, Maria Jesus Obregon, David Araujo-Vilar. Regional decrease of subcutaneous adipose tissue in patients with type 2 familial partial lipodystrophy is associated with changes in thyroid hormone metabolism. Thyroid. 2010 Apr;20(4):419-24 IF: 2.982

Parajes S, Loidi L, Reisch N, Dhir V, Rose IT, Hampel R, Quinkler M, Conway GS, Castro-Feijóo L, Araujo-Vilar D, Pombo M, Dominguez F, Williams EL, Cole TR, Kirk JM, Kaminsky E, Rumsby G, Arlt W, Krone N. Functional Consequences of Seven Novel Mutations in the CYP11B1 Gene: Four Mutations Associated with Nonclassic and Three Mutations Causing Classic 11{beta}-Hydroxylase Deficiency. J Clin Endocrinol Metab. 2010 Feb;95(2):779-88.. IF: 6.325

J.F. Ascaso, E. Aguillo, F. Calvo, R. Carmena, D. Cepero, J.M. Ibarra, J. Navarro, J. Pedro-Botet, J.J. Alemán, E. Alvárez, D. Araujo, et al. Diabetes mellitus y riesgo cardiovascular. Recomendaciones del Grupo de Trabajo Diabetes Mellitus y Enfermedad Cardiovascular de la Sociedad Española de Diabetes, 2009. Av Diabetol. 2009;25:449-54

Araújo-Vilar D, Giovanna Lattanzi, Blanca González-Méndez, Ana Teresa Costa-Freitas, Daniel Prieto, Marta Columbaro, Elisabetta Mattioli, Berta Victoria, Noelia Martínez-Sánchez, Alia Ramazanova, Máximo Fraga, Andrés Beiras, Jerónimo Forteza, Lourdes Domínguez-Gerpe, Carlos Calvo, Joaquin Lado-Abeal Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy. J. Medical Genetics 2009, 46: 40-8

Dominguez-Gerpe L, Araujo-Vilar D. Prematurely Aged Children: Molecular Alterations Leading to Hutchinson-Gilford Progeria and Werner Syndromes. Current Aging Science 2008, 1: 202-12

Clin Endocrinol (Oxf). 2008 Jul;69(1):61-8.

Lado-Abeal J, Lorenzo-Solar M, Lago-Lestón R, Palos-Paz F, Domingez-Gerpe L. Hyperglycaemic hyperosmolar nonketotic state as a cause of low gonadotrophin levels in postmenopausal diabetic women: a role for severe hypernatraemia.J Neuroendocrinol. 2007 Dec;19(12):983-7.
J Clin Endocrinol Metab. 2008 Jan;93(1):267-77.

Rodriguez-Perez A, Palos-Paz F, Kaptein E, Visser TJ, Dominguez-Gerpe L, Alvarez-Escudero J, Lado-Abeal J. Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock. Clin Endocrinol (Oxf). 2008 May;68(5):821-7.

Palos F, García-Rendueles ME, Araujo-Vilar D, Obregon MJ, Calvo RM, Cameselle-Teijeiro J, Bravo SB, Perez-Guerra O, Loidi L, Czarnocka B, Alvarez P, Refetoff S, Dominguez-Gerpe L, Alvarez CV, Lado-Abeal J. Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies.

Lado Abeal J, Pabón Castro N, Pantoja Guerrero D, Casanueva F.<>[Pseudomalabsorption of levothyroxine]An Med Interna. 2007 Feb;24(2):104-5.

Villamil Cajoto I, Araujo-Vilar, D. Tratamiento con vitamina D en la infancia: discusión de la evidencia. An. Med. Int. 2006 23:446-48.

Dumitrescu AM, Liao XH, Abdullah MS, Lado-Abeal J, Majed FA, Moeller LC, Boran G, Schomburg L, Weiss RE, Refetoff S. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism.Nat Genet. 2005 Nov;37(11):1247-52.

Lado-Abeal J, Robert-McComb JJ, Qian XP, Leproult R, Van Cauter E, Norman RL. <>Sex differences in the neuroendocrine response to short-term fasting in rhesus macaques.J Neuroendocrinol. 2005 Jul;17(7):435-44.

Graña-Barcia M, Liz-Lestón J, Lado-Abeal J. Subcutaneous administration of pulsatile gonadotropin-releasing hormone decreases serum follicle-stimulating hormone and luteinizing hormone levels in women with polycystic ovary syndrome: a preliminary study.Fertil Steril. 2005 May;83(5):1466-72.

Lado-Abeal J, Dumitrescu AM, Liao XH, Cohen RN, Pohlenz J, Weiss RE, Lebrethon MC, Verloes A, Refetoff S. A de novo mutation in an already mutant nucleotide of the thyroid hormone receptor beta gene perpetuates resistance to thyroid hormone. J Clin Endocrinol Metab. 2005 Mar;90(3):1760-7