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Personal del Grupo de Investigación

Líneas de Investigación

Desarrollo de nuevas estrategias terapéuticas en la Enfermedad de Parkinson.

Desarrollo de estrategias de neuroprotección en modelos in vivo e in vitro de degeneración dopaminérgica.

Desarrollo de métodos de proliferación y diferenciación de neuronas dopaminérgicas a partir de células troncales o células madre neurales para terapia celular en modelos animales de Enfermedad de Parkinson.

Liste, I.; Múñoz-Patiño, A.; Guerra, M.J. and Labandeira-García J.L. Fenfluramine-induced increased in preproenkephalin mRNA levels in the striatum. Interaction between the serotonergic, glutamatergic and dopaminergic systems. Synapse. 35, 182-191 (2000).

Rodríguez-Pallares, J.; Labandeira-García J.L.; Múñoz-Patiño, A. and Caruncho, H. Morphology and neurochemistry of striatal neuronal subtypes expressing in the GABAA receptor alfa-3 subunit in the rat. Brain Research. 876, 124-130 (2000).

Soto-Otero, R.; Méndez-Ávarez, E.; Hermida-Ameijeiras, A.; Múñoz-Patiño, A. and Labandeira-García, J.L. Autooxidation and Neurotoxcity of 6-Hidroxydopamine in the presence of some antioxidants: Potential implication in the relation to pathogenesis of Parkinson´s disease. Journal of Neurochemistry. 74 (4), 1605-1612 (2000).

Rodríguez-Pallares, J.; Caruncho, H.J.; Muñoz A.; Guerra, M.J. and Labandeira-García, J.L. GABAA receptor subunit expression in intrastriatal ventral mesencephalic transplants. Experimental Brain Research. 135,  331-340 (2000).

López, A.; Muñoz A; Guerra, M.J. and Labandeira-García, J.L. Mechanisms of the effects of exogenous levodopa on the dopamine-denervated striatum. Neuroscience. 103, 639-651 (2001).

Muñoz A.; López, A.; Caruncho, H.J.; Guerra, M.J. and Labandeira-García, J.L. Long-term cortical atrophy after excitoxic striatal lesion: Effects of intrastriatal fetal striatum grafts and implications for Huntington´s disease. J. Neuropathol. Exp. Neurol. 60, 786-797 (2001).

Méndez-Alvarez, E.; Soto-Otero, R.; Hermida-Ameijeiras, A.; López-Martín E. and Labandeira-García J.L. effects of iron and manganese on hydroxyl radical production by 6-hydroxydopamine: mediation of antioxidants. Free Radicals, 31 (8): 986-998 (2001).

Rodríguez-Pallares, J.; Rey, P.; Soto-Otero, R. and Labandeira-GarcíaJ.L. N-Acetylcysteirne enhances production of dopaminergic neurons from mesencephalic-derived precursors cells. Neuroreport, 12, 3935-3938 (2001).

Rodríguez-Pallares, J.; Caruncho, H.J.; López-Real, A.; Wojcik, S.; Guerra, M.J. and Labandeira-Garc��� J.L. Rat brain cholinergic, dopaminergic, noradrenergic and serotoninergic neurons express GABAA receptors derived from the alpha3 subunit. Recptors and Channels, 7(6): 471-478 (2001).

Mendez-Alvarez, E.; Soto-Otero, R.; Hermida-Ameijeiras, A.; López-Real, A. and Labandeira-Garccía, J.L. Effects of aluminium and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson?s disease. Biochimica et Biophysica Acta-Molecular Basis of Disease. 1586 (2): 155-168 (2002).

Rodríguez-Pallares, J.; Caruncho, H.J.; Guerra, M.J. and Labandeira-García,  J.L. Dipyridamole-induced increase in production of rat dopaminergic neurons from mesencephalic precursors. Neuroscience Letters. 320, 65-68 (2002).

Sánchez, B.; López-Martin, E.; Segura, S.; Labandeira-García, J.L. and Pérez-Fernandez, R. 1,25 Dihydroxyvitamin D3 increases striatal GDNF mRNA expression in adult rats. Molecular Brain Research, 108:154-157 (2002).

Soto-Otero, R.; Méndez-Álvarez, E.; Hermida-Ameijeiras, A.; López-Real, A. and Labandeira-García, J.L. Effects of (-)-nicotine and (-)- cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson?s disease . Biochemical Pharmacology. 64:125-135 (2002).

Muñoz A.; Rodriguez-Pallares, J.; Guerra, M.J. and Labandeira-García J.L. Host brain regulation of dopaminergic grafts function: the role of the serotonergic and noradrenergic system in amphetamine-induced responses. Synapse, 47:66-76 (2003).

López-Real, A.; Rodriguez-Pallares, J.; Guerra, M.J. and Labandeira-García J.L. Localization and functional significance of striatal neurons immunoreactive to aromatic L-amino acid decarboxilase or tyrosine hydroxylase in rat parkinsonian models. Brain Research, 969 (1-2):135-46 (2003).

Muñoz A.; López-Real A.; Labandeira-García, J.L. and Guerra, M.J. Interaction between the noradrenergic and serotonergic systems in locomotor hyperactivity and striatal expresion of Fos induced by amphetamine in rats. Exp. Brain Res. 153(1):92-9 (2003).

Rodriguez-Pallares, J.; Guerra, M.J. and Labandeira-García, J.L. Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors. Eur. J. Neurosc. 18(8):2166-74 (2003).

Muñoz A.; Rey, P.; Soto-Otero, R.; Guerra, M.J. and Labandeira-García, J.L. Systemic administration of N--Acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration.  J. Neurosci. Res.  15;76(4):551-62 (2004).

Rodriguez-Pallares J, Quiroz CR, Parga JA, Guerra MJ, Labandeira-Garcia JL. Angiotensin II increases differentiation of dopaminergic neurons from mesencephalic precursors via angiotensin type 2 receptors. Eur J Neurosci.  ;20(6):1489-98 (2004) .

Munoz AM, Rey P, Parga J, Guerra MJ, Labandeira-Garcia JL. Glial overexpression of heme oxygenase-1: a histochemical marker for early stages of striatal damage. J Chem Neuroanat.  29(2):113-26. (2005).

Lopez-Real A, Rey P, Soto-Otero R, Mendez-Alvarez E, Labandeira-Garcia JL. Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism. J Neurosci Res.  15;81(6):865-73 (2005).

Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL. Angiotensin II and interleukin-1 interact to increase generation of dopaminergic neurons from neurospheres of mesencephalic precursors. Brain Res Dev Brain Res.  158(1-2):120-2 (2005).

Rodriguez-Pallares J, Parga JA, Rey P, Guerra MJ, Labandeira-Garcia JL. Expanded mesencephalic precursors develop into grafts of densely packed dopaminergic neurons that reinnervate the surrounding striatum and induce functional responses in the striatal neurons.
Synapse.58(1):13-22 (2005)

Munoz A, Rey P, Guerra MJ, Mendez-Alvarez E, Soto-Otero R, Labandeira-Garcia JL. Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology.  51(1):112-20. (2006).

Parga J, Rodriguez-Pallares J, Munoz A, Guerra MJ, Labandeira-Garcia JL. Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors. J. Neurobiol.  67(1):10-22 (2006).

Sanchez-Iglesias S, Rey P, Mendez-Alvarez E, Labandeira-Garcia JL, Soto-Otero R. Time-course of brain oxidative damage caused by intrastriatal administration of 6-hydroxydopamine in a rat model of Parkinson's disease. Neurochem Res.  32(1):99-105 (2007).

Rey P, Lopez-Real A, Sanchez-Iglesias S, Munoz A, Soto-Otero R, Labandeira-Garcia JL. Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons. Neurobiol Aging. 28(4):555-67 (2007)

Parga JA, Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL. Effects of GABA and GABA receptor inhibition on differentiation of mesencephalic precursors into dopaminergic neurons in vitro. J. Neurobiol.  (Dev. Neurobiol) [Epub ahead of print] (2007).

Rodriguez-Pallares J, Parga JA, Munoz A, Rey P, Guerra MJ, Labandeira-Garcia JL. Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J Neurochem.  (2007) ; [Epub ahead of print].