Spanish version

Laboratory of Neuroanatomy and Experimental Neurology

Research Staff

José Luis Labandeira García M.D.; PhD.
Professor and laboratory head of Human Anatomy
Neurologist
Department of Morphological Sciences, Faculty of Medicine, Rúa Francisco s/n, E-15705 Santiago de Compostela, Spain.
Phone: + 34 981 56 31 00, Ext. 12223
Fax: + 34 981 54 70 78
E-mail: cmlaband@uscmail.usc.es

María Josefa Guerra Seijas, PhD.
Professor of Human Biology
Department of Morphological Sciencies, Faculty of Medicine, Rún Francisco s/n, E-15705 Santiago de Compostela, Spain.
Phone: + 34 981 56 31 00, Ext. 12209
Fax: + 34 981 54 70 78
E-mail: cmguerra@uscmail.usc.es

Jannette Rodríguez Pallares. Doctora en Ciencias Biológicas
Professor
Department of Morphological Sciencies, Faculty of Medicine, Rúa San Francisco s/n, E-15705 Santiago de Compostela, España > Tel. + 34 981 56 31 00, Ext. 12203
E-mail: cmjann@usc.es

Pilar Aldrey García Technician
Belén Joglar Santos. Graduate in Biological Sciencies
Ana López Real. M.D.,PhD.
Ana Múñoz Patiño PhD  in Biological Sciencies
Juan Andrés Parga Martín Graduate in Biological Sciencies
Pablo Rey López. PhD in Biological Sciences
Ana Isabel Rodríguez Pérez. PhD in Pharmacy
Begoña Villar Cheda. PhD in Biological Sciences

 

Research Topics

Development of new therapeutic strategies in Parkinson’s disease

Development of neuroprotective strategies in in vivo and in vitro models of dopaminergic cell degeneration

Development of new methods for proliferation and differentiation of dopaminergic neurons from stem cells or neural stem cells for cell therapy in animal models of Parkinson´s disease (PD)

 

 

 

 

Publications Peer Reviewed in Recent Years

 

 

Liste, I.; Múñoz-Patiño, A.; Guerra, M.J. and Labandeira-García J.L. Fenfluramine-induced increased in preproenkephalin mRNA levels in the striatum. Interaction between the serotonergic, glutamatergic and dopaminergic systems. Synapse. 35, 182-191 (2000).

Rodríguez-Pallares, J.; Labandeira-García J.L.; Múñoz-Patiño, A. and Caruncho, H. Morphology and neurochemistry of striatal neuronal subtypes expressing in the GABAA receptor alfa-3 subunit in the rat. Brain Research. 876, 124-130 (2000).

Soto-Otero, R.; Méndez-Ávarez, E.; Hermida-Ameijeiras, A.; Múñoz-Patiño, A. and Labandeira-García, J.L. Autooxidation and Neurotoxcity of 6-Hidroxydopamine in the presence of some antioxidants: Potential implication in the relation to pathogenesis of Parkinson´s disease. Journal of Neurochemistry. 74 (4), 1605-1612 (2000).

Rodríguez-Pallares, J.; Caruncho, H.J.; Muñoz A.; Guerra, M.J. and Labandeira-García, J.L. GABAA receptor subunit expression in intrastriatal ventral mesencephalic transplants. Experimental Brain Research. 135,  331-340 (2000).

López, A.; Muñoz A; Guerra, M.J. and Labandeira-García, J.L. Mechanisms of the effects of exogenous levodopa on the dopamine-denervated striatum. Neuroscience. 103, 639-651 (2001).

Muñoz A.; López, A.; Caruncho, H.J.; Guerra, M.J. and Labandeira-García, J.L. Long-term cortical atrophy after excitoxic striatal lesion: Effects of intrastriatal fetal striatum grafts and implications for Huntington´s disease. J. Neuropathol. Exp. Neurol. 60, 786-797 (2001).

Méndez-Alvarez, E.; Soto-Otero, R.; Hermida-Ameijeiras, A.; López-Martín E. and Labandeira-García J.L. effects of iron and manganese on hydroxyl radical production by 6-hydroxydopamine: mediation of antioxidants. Free Radicals, 31 (8): 986-998 (2001).

Rodríguez-Pallares, J.; Rey, P.; Soto-Otero, R. and Labandeira-GarcíaJ.L. N-Acetylcysteirne enhances production of dopaminergic neurons from mesencephalic-derived precursors cells. Neuroreport, 12, 3935-3938 (2001).

Rodríguez-Pallares, J.; Caruncho, H.J.; López-Real, A.; Wojcik, S.; Guerra, M.J. and Labandeira-Garc J.L. Rat brain cholinergic, dopaminergic, noradrenergic and serotoninergic neurons express GABAA receptors derived from the alpha3 subunit. Recptors and Channels, 7(6): 471-478 (2001).

Mendez-Alvarez, E.; Soto-Otero, R.; Hermida-Ameijeiras, A.; López-Real, A. and Labandeira-Garccía, J.L. Effects of aluminium and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson?s disease. Biochimica et Biophysica Acta-Molecular Basis of Disease. 1586 (2): 155-168 (2002).

Rodríguez-Pallares, J.; Caruncho, H.J.; Guerra, M.J. and Labandeira-García,  J.L. Dipyridamole-induced increase in production of rat dopaminergic neurons from mesencephalic precursors. Neuroscience Letters. 320, 65-68 (2002).

Sánchez, B.; López-Martin, E.; Segura, S.; Labandeira-García, J.L. and Pérez-Fernandez, R. 1,25 Dihydroxyvitamin D3 increases striatal GDNF mRNA expression in adult rats. Molecular Brain Research, 108:154-157 (2002).

Soto-Otero, R.; Méndez-Álvarez, E.; Hermida-Ameijeiras, A.; López-Real, A. and Labandeira-García, J.L. Effects of (-)-nicotine and (-)- cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson?s disease . Biochemical Pharmacology. 64:125-135 (2002).

Muñoz A.; Rodriguez-Pallares, J.; Guerra, M.J. and Labandeira-García J.L. Host brain regulation of dopaminergic grafts function: the role of the serotonergic and noradrenergic system in amphetamine-induced responses. Synapse, 47:66-76 (2003).

López-Real, A.; Rodriguez-Pallares, J.; Guerra, M.J. and Labandeira-García J.L. Localization and functional significance of striatal neurons immunoreactive to aromatic L-amino acid decarboxilase or tyrosine hydroxylase in rat parkinsonian models. Brain Research, 969 (1-2):135-46 (2003).

Muñoz A.; López-Real A.; Labandeira-García, J.L. and Guerra, M.J. Interaction between the noradrenergic and serotonergic systems in locomotor hyperactivity and striatal expresion of Fos induced by amphetamine in rats. Exp. Brain Res. 153(1):92-9 (2003).

Rodriguez-Pallares, J.; Guerra, M.J. and Labandeira-García, J.L. Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors. Eur. J. Neurosc. 18(8):2166-74 (2003).

Muñoz A.; Rey, P.; Soto-Otero, R.; Guerra, M.J. and Labandeira-García, J.L. Systemic administration of N--Acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration.  J. Neurosci. Res.  15;76(4):551-62 (2004).

Rodriguez-Pallares J, Quiroz CR, Parga JA, Guerra MJ, Labandeira-Garcia JL. Angiotensin II increases differentiation of dopaminergic neurons from mesencephalic precursors via angiotensin type 2 receptors. Eur J Neurosci.  ;20(6):1489-98 (2004) .

Munoz AM, Rey P, Parga J, Guerra MJ, Labandeira-Garcia JL. Glial overexpression of heme oxygenase-1: a histochemical marker for early stages of striatal damage. J Chem Neuroanat.  29(2):113-26. (2005).

Lopez-Real A, Rey P, Soto-Otero R, Mendez-Alvarez E, Labandeira-Garcia JL. Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism. J Neurosci Res.  15;81(6):865-73 (2005).

Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL. Angiotensin II and interleukin-1 interact to increase generation of dopaminergic neurons from neurospheres of mesencephalic precursors. Brain Res Dev Brain Res.  158(1-2):120-2 (2005).

Rodriguez-Pallares J, Parga JA, Rey P, Guerra MJ, Labandeira-Garcia JL. Expanded mesencephalic precursors develop into grafts of densely packed dopaminergic neurons that reinnervate the surrounding striatum and induce functional responses in the striatal neurons.
 Synapse.58(1):13-22 (2005)

Munoz A, Rey P, Guerra MJ, Mendez-Alvarez E, Soto-Otero R, Labandeira-Garcia JL. Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology.  51(1):112-20. (2006).

Parga J, Rodriguez-Pallares J, Munoz A, Guerra MJ, Labandeira-Garcia JL. Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors. J.  Neurobiol.  67(1):10-22 (2006).

Sanchez-Iglesias S, Rey P, Mendez-Alvarez E, Labandeira-Garcia JL, Soto-Otero R. Time-course of brain oxidative damage caused by intrastriatal administration of 6-hydroxydopamine in a rat model of Parkinson's disease. Neurochem Res.  32(1):99-105 (2007).

Rey P, Lopez-Real A, Sanchez-Iglesias S, Munoz A, Soto-Otero R, Labandeira-Garcia JL. Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons. Neurobiol Aging. 28(4):555-67 (2007)

Parga JA, Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL. Effects of GABA and GABA receptor inhibition on differentiation of mesencephalic precursors into dopaminergic neurons in vitro. J. Neurobiol. (Dev. Neurobiol)  [Epub ahead of print] (2007).

Rodriguez-Pallares J, Parga JA, Munoz A, Rey P, Guerra MJ, Labandeira-Garcia JL. Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J Neurochem.  (2007) ; [Epub ahead of print].