PhD Position "Synthetic Peptide Scaffolds as Functional Protofilaments under Confinement" within Horizon Europe MSCA Doctoral Network “ComeInCell”
The Center for Research in Biological Chemistry and Molecular Materials (CiQUS) is a leading research environment in molecular materials and supramolecular chemistry applied to synthetic biology.
Dr. Javier Montenegro's group, renowned for pioneering approaches in this field, is seeking a Doctoral Candidate to join the project "Synthetic Peptide Scaffolds as Functional Protofilaments under Confinement", funded by the H2020-MSCA-DN-2023. This position offers a unique opportunity to contribute to groundbreaking research within an international European network.
This is a position within the framework of the Marie Curie Doctoral Training Network “ComeInCell: Condensates at Membrane Scaffolds – Integrated Systems as Synthetic Cell Compartments”.
Project Title: Synthetic peptide scaffolds as functional protofilaments under confinement.
Reference Number: ComeInCell_DC_09
Host Institution: University of Santiago de Compostela (USC), Santiago de Compostela, Spain
Research Group: Montenegro Lab, www.javiermontenegrochemistry.com
Supervisor: Dr. Javier Montenegro
DESCRIPTION
The Montenegro Lab specialises in the application of supramolecular chemistry to synthetic biology and functional molecular materials. This project explores synthetic peptide scaffolds and their potential to form functional protofilaments under confined conditions. By utilising self-assembling peptide amphiphiles, the research investigates confinement-induced behaviours such as substance uptake, compartment deformation, and coalescence. The project carefully modulates the hydrophobicity of peptide amphiphiles to optimise interactions with lipid/polymer membranes, with a focus on fibrillation influenced by external factors like pH or salt concentration.
Expected Outcomes include:
· Characterization of partition coefficients for peptide amphiphiles in various condensates and vesicles.
· Investigation of emergent properties of self-assembling fibers.
· Application of these fibrillating synthetic cells to modulate biological functions like uptake, release, localization, and cytotoxicity.
The ultimate goal is to harness these interactions for applications in membrane repair and targeted drug delivery.
REQUIREMENTS
Mobility Conditions:
MSCA networks require that applicants must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting organisation for more than 12 months in the 36 months immediately before their recruitment date.
Essential Qualifications:
· MSc or equivalent degree in Chemistry, Biology, Biochemistry, or related fields.
· Knowledge in at least one of the following areas: supramolecular chemistry, peptide chemistry, molecular biology, or synthetic biology.
Desirable Qualifications:
· Experience in peptide synthesis and characterisation.
· Familiarity with biophysical techniques and data analysis.
· Good communication skills and proficiency in written and spoken English are essential.
STARTING DATE AND TERM
The selected candidate will be offered a 36-month employment contract and will be enrolled in a structured 3-year PhD programme. The project is planned to start on the 1st of March 2025 or a few months later, depending on candidate availability.
FUNDING INFORMATION
This position is funded by H2020-MSCA-DN-2023 (Project Nr: 101168939). MSCA Doctoral Networks offer attractive salary terms and benefits, including:
• A gross living allowance of approximately €3,400/month (subject to country correction coefficient).
• A mobility allowance of €600/month.
• A family allowance of €660/month (if applicable).
Note: These amounts are gross values, and employer costs or other deductions depend on the recruiting host institution.
APPLICATION PROCESS
To apply or informal inquiries, please send a e-mail to Patricia Lago p.lago [at] usc.es (subject: Comincell%20PhD%20application) with the subject "Comincell PhD application” before 31 December 2024.
The initial eligibility assessment will be conducted based on submitted applications. Successful candidates will then be requested to submit complete application packages through institution-specific links.
Required Documents:
• Motivation letter detailing relevant skills and experiences.
• CV including academic achievements and publication list (if any).
• Copies of Bachelor’s and Master’s Degree certificates with transcripts.
• Contact information for references (e.g., MSc supervisor)
Further information on the research interests of the Montenegro Group can be found at www.javiermontenegrochemistry.com.
