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ORIGINAL ARTICLES IN SCIENTIFIC JOURNALS

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Caterina Pont, Anna Sampietro, F Javier Pérez-Areales, Nunzia Cristiano, Agustí Albalat, Belén Pérez, Manuela Bartolini, Angela De Simone, Vincenza Andrisano, Marta Barenys , Elisabet Teixidó, Raimon Sabaté, M Isabel Loza, José Brea, Diego Muñoz-Torrero. Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties Pharmaceutics. 2024 Jul 25;16(8):982. doi: 10.3390/pharmaceutics16080982.

Roberto Debbag, María L Ávila-Agüero, José Brea, Helena Brenes-Chacon, Manuel Colomé, Rodrigo de Antonio, Alejandro Díaz-Díaz, Luiza Helena Falleiros-Arlant, Gerardo Fernández, Angela Gentile, Iván Felipe Gutiérrez, Daniel Jarovsky, María Del Valle Juárez, Eduardo López-Medina, Abiel Mascareñas, Sebastián Ospina-Henao, Marco A Safadi, Xavier Sáez-Llorens, Alejandra Soriano-Fallas, Juan P Torres, Carlos N Torres-Martínez, Claudia Beltrán-Arroyave. Confronting the challenge: a regional perspective by the Latin American pediatric infectious diseases society (SLIPE) expert group on respiratory syncytial virus-tackling the burden of disease and implementing preventive solutions Front Pediatr. 2024 Jul 31:12:1386082. doi: 10.3389/fped.2024.1386082. eCollection 2024.

Kossatz E, Diez z-Alarcia R, Gaitonde SA, Ramon-Duaso C, Stepniewski TM, Aranda-Garcia D, Muneta-Arrate I, Tepaz E, Saen-Oon S, Soliva R, Shahraki A, Moreira D, Brea J, Loza MI, de la Torre R, Kolb, PBouvier M, Meana JJ, Robledo P, Selent J. G-protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits Nat Commun. 2024 May 29;15(1):4307. doi: 10.1038/s41467-024-48196-2.

Mireya L Borrajo, Gustavo Lou, Shubaash Anthiya, Philipp Lapuhs, David Moreira Álvarez, Araceli Tobío, María Isabel Loza, Anxo Vidal, María José Alonso. Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines Drug Deliv Transl Res. 2024 Aug;14(8):2046-2061. doi: 10.1007/s13346-024-01635-5. Epub 2024 May 29.

Francesca Intranuovo, Maria Majellaro, Francesco Mastropasqua, Pietro Delre, Francesca Serena Abatematteo, Giuseppe Felice Mangiatordi, Angela Stefanachi, Josè Brea, Maria Isabel Loza, Chiara Riganti, Alessia Ligresti, Poulami Kumar, Daniela Esposito, Luigia Cristino, Alessandro Nicois, Lucía González, Maria Grazia Perrone, Nicola Antonio Colabufo, Eddy Sotelo, Carmen Abate, Marialessandra Contino. N-Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) J Med Chem. 2024 Jun 27. doi: 10.1021/acs.jmedchem.4c00564. Online ahead of print.

Areias, Filipe ;Correia, Carla ;Rocha, Ashly ;Teixeira, Sofia ;Castro, Marian ;Brea, Jose ;Hu, Huabin ;Carlsson, Jens ;Loza, Maria I. ;Proenca, M. Fernanda ;Carvalho, M. Alice. 2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives Molecules. 2024 May 28;29(11):2543. doi: 10.3390/molecules29112543.

Ramón Rama-Garda, Eduardo Domínguez, María Isabel Loza, María José Lallena, Jesús de Blas, Miguel Ángel Toledo, Rubén Haro. High-Throughput DNA-Encoded Libraries Affinity Selection Platform for Binder Identification with Solid Support Protein Immobilization Assay Drug Dev Technol. 2024 Apr 19. doi: 10.1089/adt.2024.010. Online ahead of print.

Brea J, Varela MJ, Daudey GA, Loza MI. High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries SLAS Discov. 2024 Mar 6:100149. doi: 10.1016/j.slasd.2024.100149. Online ahead of print.

Rubén Prieto-Díaz 1, Hugo Fojo-Carballo 1, Maria Majellaro 2, Tana Tandarić 3, Jhonny Azuaje 1, José Brea 4, María I Loza 5, Jorge Barbazán 6, Glòria Salort 7, Meera Chotalia 1, Iván Rodríguez-Pampín 1, Ana Mallo-Abreu 1, M Rita Paleo 1, Xerardo García-Mera 8, Francisco Ciruela 9, Hugo Gutiérrez-de-Terán 10, Eddy Sotelo 11 Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents Biomed Pharmacother. 2024 Mar 4:173:116345. doi: 10.1016/j.biopha.2024.116345. Online ahead of print.

A L Martínez, J Brea, D López, N Cosme, M Barro, X Monroy, J Burgueño, M Merlos, M I Loza In Vitro Models for Neuropathic Pain Phenotypic Screening in Brain Therapeutics Pharmacol Res. 2024 Feb 19:107111. doi: 10.1016/j.phrs.2024.107111. Online ahead of print.

Santiago Grau, José Miguel Vela, Alba Gurt, Jaime Barceló-Vidal, Fabiola Ojeda, Iago López, Laura Gómez-García, María Isabel Loza, Elena Martín-García, Rafael Maldonado, Jordi Monfort; SIGMA Group Efficacy of SIGMAR1-based therapy in the early treatment of confirmed mild symptomatic COVID-19 patients J Infect. 2024 Feb;88(2):187-190. doi: 10.1016/j.jinf.2023.11.008. Epub 2023 Nov 21.

Ramón Rama-Garda 1, María Dolores Martin-Ortega 2, Anthony de Jesús Sánchez 3, Julián Priego 2, Jesús de Blas 2, Alicia Torrado 2, Eduardo Domínguez 4, Rubén Haro 2, Alfonso Rivera-Sagredo 2, José Pablo Román 2, María José Lorite 2, Hans E Johansson 3, María Isabel Loza 5, Jorge Amigo 6, Beatriz Sobrino 6, María José Lallena 2, Miguel Ángel Toledo 2 Design, synthesis and validation of a new Crimped Head-Piece for DNA-Encoded libraries generation Bioorg Med Chem. 2024 Feb 1:99:117596. doi: 10.1016/j.bmc.2024.117596. Epub 2024 Jan 11.

Gemma Navarro , Eddy Sotelo , Iu Raïch , María Isabel Loza, Jose Brea, and Maria Majellaro A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery Molecules. 2023 Dec 15;28(24):8107. doi: 10.3390/molecules28248107.

Clément Anfray, Carmen Fernández Varela, Aldo Ummarino, Akihiro Maeda, Marina Sironi, Sara Gandoy, Jose Brea, María Isabel Loza, Sergio León, Alfonso Calvo, Juan Correa, Eduardo Fernandez-Megia, María José Alonso, Paola Allavena, José Crecente-Campo, Fernando Torres Andón Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors Front Immunol. 2024 Jan 8:14:1334800. doi: 10.3389/fimmu.2023.1334800. eCollection 2023.

Breno A Soares, Thirumal Yempala, Darío Martínez-Afani, Williams Acevedo-Fuentes, José Brea, María Isabel Loza, Marta Cimadevila, Bruce K Cassels Effect of Bulky N-Dibenzofuranylmethyl Substitution on the 5-HT2 Receptor Affinity and Efficacy of a Psychedelic Phenethylamine ACS Chem Neurosci. 2024 Jan 19. doi: 10.1021/acschemneuro.3c00639. Online ahead of print.

Sara C. Silva-Reis, Xavier C. Correia, Hugo F. Costa-Almeida, Beatriz L. Pires-Lima, Daiane Maronde, Vera M. Costa, Xerardo García-Mera, Luís Cruz, José Brea, María Isabel Loza, José E. Rodríguez-Borges, and Ivo E. Sampaio-Dias Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors ACS Med Chem Lett. 2023 Nov 14;14(12):1656-1663. doi: 10.1021/acsmedchemlett.3c00264. eCollection 2023 Dec 14.

Fernández DI, Diender M, Hermida-Nogueira L, Huang J, Veiras S, Henskens YMC, Te Loo MWM, Heemskerk JWM, Kuijpers MJE, García Á Role of SHP2 (PTPN11) in glycoprotein VI-dependent thrombus formation: Improved platelet responsiveness by the allosteric drug SHP099 in Noonan syndrome patients Thromb Res. 2023 Jun 5;228:105-116. doi: 10.1016/j.thromres.2023.06.001.

Piotr Stępnicki, Katarzyna M Targowska-Duda, Antón L Martínez, Agata Zięba, Olga Wronikowska-Denysiuk, Martyna Z Wróbel, Agata Bartyzel, Alicja Trzpil, Tomasz M Wróbel, Andrzej Chodkowski, Karolina Mirecka, Tadeusz Karcz, Katarzyna Szczepańska, Maria I Loza, Barbara Budzyńska, Jadwiga Turło, Jadwiga Handzlik, Emilia Fornal, Ewa Poleszak, Marián Castro, Agnieszka A Kaczor Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling Eur J Med Chem. 2023 Apr 5:252:115285. doi: 10.1016/j.ejmech.2023.115285. Epub 2023 Mar 17.

Luis Filipe Costa-Machado, Esther Garcia-Dominguez, Rebecca L McIntyre, Jose Luis Lopez-Aceituno, Álvaro Ballesteros-Gonzalez, Andrea Tapia-Gonzalez, David Fabregat-Safont, Tobias Eisenberg, Jesús Gomez, Adrian Plaza, Aranzazu Sierra-Ramirez, Manuel Perez, David Villanueva-Bermejo, Tiziana Fornari, María Isabel Loza, Gonzalo Herradon, Sebastian J Hofer, Christoph Magnes, Frank Madeo, Janet S Duerr, Oscar J Pozo, Maximo-Ibo Galindo, Isabel Del Pino, Riekelt H Houtkooper, Diego Megias, Jose Viña, Mari Carmen Gomez-Cabrera, Pablo J Fernandez-Marcos Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models Nat Commun. 2 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y.

Santiago Grau 1, José Miguel Vela, Alba Gurt, Jaime Barceló-Vidal, Fabiola Ojeda, Iago López, Laura Gómez-García, María Isabel Loza, Elena Martín-García, Rafael Maldonado, Jordi Monfort; SIGMA Group Efficacy of SIGMAR1-based therapy in the early treatment of confirmed mild symptomatic COVID-19 patients J Infect. 2024 Feb;88(2):187-190. doi: 10.1016/j.jinf.2023.11.008. Epub 2023 Nov 21.

Breno A Soares, Thirumal Yempala, Darío Martínez-Afani, Williams Acevedo-Fuentes, José Brea, María Isabel Loza, Marta Cimadevila, Bruce K Cassels Effect of Bulky N-Dibenzofuranylmethyl Substitution on the 5-HT2 Receptor Affinity and Efficacy of a Psychedelic Phenethylamine Thromb Res. 2023 Jun 5;228:105-116. doi: 10.1016/j.thromres.2023.06.001.

Shubaash Anthiya, Süleyman Can Öztürk, Hamdullah Yanik, Ece Tavukcuoglu, Adem Şahin, Dhrubajyoti Datta, Klaus Charisse, David Moreira Álvarez, María Isabel Loza, Alfonso Calvo, Einar Sulheim, Simon Loevenich, Geir Klinkenberg, Ruth Schmid, Muthiah Manoharan, Güneş Esendağlı, Maria Jose Alonso Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors J Control Release. 2023 May:357:67-83. doi: 10.1016/j.jconrel.2023.03.016. Epub 2023 Mar 28.

Claudia Gioé-Gallo, Sandra Ortigueira, José Brea, Iu Raïch, Jhonny Azuaje, M Rita Paleo, Maria Majellaro, María Isabel Loza, Cristian O Salas, Xerardo García-Mera, Gemma Navarro, Eddy Sotelo Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs Biomed Pharmacother. 2023 May 24;164:114934. doi: 10.1016/j.biopha.2023.114934. Online ahead of print.

Marianna Stampolaki, Satish R Malwal, Nadine Alvarez-Cabrera, Zijun Gao, Mohammad Moniruzzaman, Svitlana O Babii, Nikolaos Naziris, André Rey-Cibati, Mariana Valladares-Delgado, Andreea L Turcu, Kyung-Hwa Baek, Trong-Nhat Phan, Hyeryon Lee, Mattheo Alcaraz, Savannah Watson, Mariette van der Watt, Dina Coertzen, Natasa Efstathiou, Maria Chountoulesi, Carolyn M Shoen, Ioannis P Papanastasiou, Jose Brea, Michael H Cynamon, Lyn-Marié Birkholtz, Laurent Kremer, Joo Hwan No, Santiago Vázquez, Gustavo Benaim, Costas Demetzos, Helen I Zgurskaya, Thomas Dick, Eric Oldfield, Antonios D Kolocouris Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites ACS Infect Dis. 2023 Jan 27. doi: 10.1021/acsinfecdis.2c00537.

Maris-Johanna Tahk, Tõnis Laasfeld, Elo Meriste, Jose Brea, Maria Isabel Loza, Maria Majellaro, Marialessandra Contino, Eddy Sotelo, Ago Rinken Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells Front Mol Biosci. 2023 Mar 16:10:1119157. doi: 10.3389/fmolb.2023.1119157. eCollection 2023.

Eric March-Vila, Giacomo Ferretti, Emma Terricabras, Inés Ardao, José Manuel Brea, María José Varela, Álvaro Arana, Juan Andrés Rubiolo, Ferran Sanz, María Isabel Loza, Laura Sánchez, Héctor Alonso, Manuel Pastor A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry Arch Toxicol. 2023 Apr;97(4):1091-1111. doi: 10.1007/s00204-023-03459-7. Epub 2023 Feb 12.

Battistina Asproni, Marco Catto, Giovanni Loriga, Gabriele Murineddu, Paola Corona, Rosa Purgatorio, Elena Cichero, Paola Fossa, Naomi Scarano, Antón L Martínez, José Brea, Gérard A Pinna Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 2023 Apr 15:84:117256. doi: 10.1016/j.bmc.2023.117256. Epub 2023 Mar 21.

Giovanni Graziano, Pietro Delre, Francesca Carofiglio, Josè Brea, Alessia Ligresti, Magdalena Kostrzewa, Chiara Riganti, Claudia Gioè-Gallo, Maria Majellaro, Orazio Nicolotti, Nicola Antonio Colabufo, Carmen Abate, Maria Isabel Loza, Eddy Sotelo, Giuseppe Felice Mangiatordi, Marialessandra Contino, Angela Stefanachi, Francesco Leonetti N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) Eur J Med Chem. 2023 Feb 15;248:115109. doi: 10.1016/j.ejmech.2023.115109. Epub 2023 Jan 13.

Maria J Matos, Paula Novo, Lucía Mayán, Iria Torres, Eugenio Uriarte, Matilde Yáñez, José Ángel Fontenla, Francesco Ortuso, Stefano Alcaro, Francesca Procopio, María Isabel Rodríguez-Franco, Cristina Val, María I Loza, José Brea, Fernanda Borges, Dolores Viña 8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies Eur J Med Chem. 2023 Feb 15;248:115091. doi: 10.1016/j.ejmech.2023.115091. Epub 2023 Jan 7.

Francesca Intranuovo, Leonardo Brunetti, Pietro DelRe, Giuseppe Felice Mangiatordi, Angela Stefanachi, Antonio Laghezza, Mauro Niso, Francesco Leonetti, Fulvio Loiodice, Alessia Ligresti, Magdalena Kostrzewa, Jose Brea, Maria Isabel Loza, Eddy Sotelo, Michele Saviano, Nicola Antonio Colabufo, Chiara Riganti, Carmen Abate, Marialessandra Contino Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase J Med Chem. 2023 Jan 12;66(1):235-250. doi: 10.1021/acs.jmedchem.2c01084. Epub 2022 Dec 21.

Rubén Prieto-Díaz, Manuel González-Gómez, Hugo Fojo-Carballo, Jhonny Azuaje, Abdelaziz El Maatougui, Maria Majellaro, María I Loza, José Brea, Víctor Fernández-Dueñas, M Rita Paleo, Alejandro Díaz-Holguín, Beatriz Garcia-Pinel, Ana Mallo-Abreu, Juan C Estévez, Antonio Andújar-Arias, Xerardo García-Mera, Iria Gomez-Tourino, Francisco Ciruela, Cristian O Salas, Hugo Gutiérrez-de-Terán, Eddy Sotelo Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists J Med Chem. 2023 Jan 12;66(1):890-912. doi: 10.1021/acs.jmedchem.2c01768. Epub 2022 Dec 14.

Maria Isabel Loza1, Julija Hmeljak, Chas Bountra, James E. Audia, Sohini Chowdhury, Shannon Weiman, Kalpana Merchant and Maria-Jesus Blanco Collaboration and knowledge integration for successful brain therapeutics – lessons learned from the pandemic Dis Model Mech. 2022 Dec 1;15(12):dmm049755. doi: 10.1242/dmm.049755. Epub 2022 Dec 21.

Noemí Vila, Pedro Besada, José Brea, María Isabel Loza, Carmen Terán Novel Phthalazin-1(2H)-One Derivatives Displaying a Dithiocarbamate Moiety as Potential Anticancer Agents Molecules. 2022 Nov 22;27(23):8115. doi: 10.3390/molecules27238115.

Andrea Astolfi, Francesca Milano, Deborah Palazzotti, Jose Brea, Maria Chiara Pismataro, Mariangela Morlando, Oriana Tabarrini, Maria Isabel Loza, Serena Massari, Maria Paola Martelli, Maria Letizia Barreca From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3- d]pyrimidin-4(3 H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia Pharmaceutics. 2022 Oct 26;14(11):2295. doi: 10.3390/pharmaceutics14112295.

Sandra Codony, José M Entrena, Carla Calvó-Tusell, Beatrice Jora, Rafael González-Cano, Sílvia Osuna, Rubén Corpas, Christophe Morisseau, Belén Pérez, Marta Barniol-Xicota, Christian Griñán-Ferré, Concepción Pérez, María Isabel Rodríguez-Franco, Antón L Martínez, M Isabel Loza, Mercè Pallàs, Steven H L Verhelst,Coral Sanfeliu, Ferran Feixas, Bruce D Hammock, José Brea, Enrique J Cobos, Santiago Vázquez Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors J Med Chem.2022 Oct 12. doi: 10.1021/acs.jmedchem.2c00515. Online ahead of print.

Gaëtan Chicanne, Maria N Barrachina, Anaelle Durbec, Justine Bertrand-Michel, Sara Troitiño, Lidia Hermida-Nogueira, Aurelio M Sueiro, María Pardo, Bernard Payrastre, Ángel García Platelet Lipidome Fingerprint: New Assistance to Characterize Platelet Dysfunction in Obesity Int J Mol Sci.2022 Jul 28;23(15):8326. doi: 10.3390/ijms23158326..

Jorge Barbazán, Maria Majellaro, Antón L Martínez, José M Brea, Eddy Sotelo, Miguel Abal Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands Biomed Pharmacother.2022 Sep;153:113408. doi: 10.1016/j.biopha.2022.113408. Epub 2022 Jul 18.

Ana Martínez, Olga Genilloud, M Jesús Vicent,José Manuel Brea, Carmen Gil, M Mar Orzaez, M Isabel Loza. EUROPEAN-OPENSCREEN SEBMM. 2022 Jun. Artículo divulgativo.

Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de Los Frailes, Richard S Roberts, Juan A Ballesteros, Fernando Rodríguez de Fonseca, Bellinda Benhamú, María I Loza, María L López-Rodríguez 2-(Fluoromethoxy)-4'-( S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D 1 Receptor for Parkinson's Disease J Med Chem.2022 Aug 31. doi: 10.1021/acs.jmedchem.2c00949. Online ahead of print.

Magda Kondej, Tomasz M Wróbel, Katarzyna M Targowska-Duda, Antón Leandro Martínez, Oliwia Koszła, Piotr Stępnicki, Agata Zięba, Alba Paz, Olga Wronikowska-Denysiuk, Maria I Loza, Marián Castro, Agnieszka A Kaczor Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety ChemMedChem.2022 May 24;e202200238.DOI: 10.1002/cmdc.202200238. 5. ChemMedChem, Vol. 17, Núm. 15.

Andrea Bagán, José A Morales-García, Christian Griñán-Ferré, Caridad Díaz, José Pérez Del Palacio, Maria C Ramos, Francisca Vicente, Belén Pérez, José Brea, María Isabel Loza, Mercè Pallàs, Carmen Escolano Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I 2 Receptor Ligand B06 Int J Mol Sci.2022 May 12;23(10):5408.DOI: 10.3390/ijms23105408.

Apple Hui Min Tay, Rubén Prieto-Díaz, Shiyong Neo, Le Tong, Xinsong Chen, Valentina Carannante, Björn Önfelt, Johan Hartman, Felix Haglund, Maria Majellaro, Jhonny Azuaje, Xerardo Garcia-Mera, Jose M Brea, Maria I Loza, Willem Jespers, Hugo Gutierrez-de-Teran, Eddy Sotelo, Andreas Lundqvist A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models J Immunother Cancer. 2022 May;10(5):e004592.DOI: 10.1136/jitc-2022-004592.

Oliwia Koszła 1, Przemysław Sołek 2, Ewa Kędzierska 3, Piotr Listos 4, Marián Castro 5, Agnieszka A Kaczor 6 7 In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1 Neurochem Res. 2022 Jun;47(6):1778-1789. doi: 10.1007/s11064-022-03570-8. Epub 2022 Apr 5.2022 Jun 5;236:114354. doi: 10.1016/j.ejmech.2022.114354. Epub 2022 Apr 8.

Andreea L Turcu, Júlia Companys-Alemany, Matthew B Phillips, Dhilon S Patel, Christian Griñán-Ferré, M Isabel Loza, José M Brea, Belén Pérez, David Soto, Francesc X Sureda, Maria G Kurnikova, Jon W Johnson, Mercè Pallàs, Santiago Vázquez Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease Eur J Med Chem. 2022 Apr 8;236:114354.DOI: 10.1016/j.ejmech.2022.114354. Online ahead of print.

Antón L Martínez, José Brea, Eduardo Domínguez, María J Varela, Catarina Allegue, Raquel Cruz, Xavier Monroy, Manuel Merlos, Javier Burgueño, Ángel Carracedo, María Isabel Loza Identification of Sodium Transients Through Na V 1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons Front Cell Neurosci.2022 Apr 6;16:816325. DOI: 10.3389/fncel.2022.816325. eCollection 2022.

Sandra Codony, Caterina Pont, Christian Griñán-Ferré, Ania Di Pede-Mattatelli, Carla Calvó-Tusell, Ferran Feixas, Sílvia Osuna, Júlia Jarné-Ferrer, Marina Naldi, Manuela Bartolini, María Isabel Loza, José Brea, Belén Pérez, Clara Bartra, Coral Sanfeliu, Jordi Juárez-Jiménez, Christophe Morisseau, Bruce D Hammock, Mercè Pallàs, Santiago Vázquez, Diego Muñoz-Torrero Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease J Med Chem.022 Mar 24;65(6):4909-4925. DOI: 10.1021/acs.jmedchem.1c02150. Epub 2022 Mar 10.

Juan M Decara, Henar Vázquez-Villa, José Brea, Mónica Alonso, Raj Kamal Srivastava, Laura Orio, Francisco Alén, Juan Suárez, Elena Baixeras, Javier García-Cárceles, Andrea Escobar-Peña, Beat Lutz, Ramón Rodríguez, Eva Codesido, F Javier Garcia-Ladona, Teresa A Bennett, Juan A Ballesteros, Jacobo Cruces , María I Loza, Bellinda Benhamú, Fernando Rodríguez de Fonseca, María L López-Rodríguez Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity" J Med Chem. 22022 Mar 29. DOI: 10.1021/acs.jmedchem.1c01842. Online ahead of print.

María Carmen Costas-Lago, Noemí Vila, Adeyemi Rahman, Pedro Besada, Isabel Rozas, José Brea, María Isabel Loza, Elisa González-Romero, Carmen Terán Novel Pyridazin-3(2 H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity ACS Med Chem Lett. 2022 Feb 10;13(3):463-469. DOI: 10.1021/acsmedchemlett.1c00633. eCollection 2022 Mar 10.

Martínez, A.L., Brea, J., Castro, M., García, Á., Santamaría, E., Lestón, Ó., Loza, M.I. 1 An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery International Journal of Emerging Technologies in Learning. Vol. 17, Núm. 6, pp. 257-267. DOI: 10.3991/IJET.V17I06.28149.

Darío Miranda-Pastoriza, Rodrigo Bernárdez, Jhonny Azuaje, Rubén Prieto-Díaz, Maria Majellaro, Ashish V Tamhankar, Lucien Koenekoop, Alejandro González, Claudia Gioé-Gallo, Ana Mallo-Abreu, José Brea, M Isabel Loza, Aitor García-Rey, Xerardo García-Mera, Hugo Gutiérrez-de-Terán, Eddy Sotelo Exploring Non-orthosteric Interactions with a Series of Potent and Selective A 3 Antagonists ACS Med Chem Lett. 2022 Jan 10;13(2):243-249. DOI: 10.1021/acsmedchemlett.1c00598. eCollection 2022 Feb 10.

Margherita Mastromarino, Mauro Niso, Carmen Abate, Ewgenij Proschak, Mariam Dubiel, Holger Stark, Marián Castro, Enza Lacivita, Marcello Leopoldo Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties Molecules. 2022 Feb 15;27(4):1297. DOI: 10.3390/molecules27041297.

Luis A Morán, Ying Di, Marcin A Sowa, Lidia Hermida-Nogueira, María N Barrachina, Eleyna Martin, Todd H Mize, Joanne C Clark, Johannes A Eble, David Moreira, Alice Y Pollitt, María I Loza, Eduardo Domínguez, Steve P Watson, Angel Garcia. Katacine is a new ligand of CLEC-2 that acts as a platelet agonist Thromb Haemost. 2022 Feb 15. DOI: 10.1055/a-1772-1069. Online ahead of print.

Justyna Żuk, Damian Bartuzi, Andrea G Silva, Monika Pitucha, Oliwia Koszła, Tomasz M Wróbel, Dariusz Matosiuk, Marián Castro, Agnieszka A Kaczor Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications Pharmacol Rep. 2022 Apr;74(2):406-424. Epub 2022 Jan 22. DOI: 10.1007/s43440-021-00352-x.

Cristina Val, Carlos Rodríguez-García, Rubén Prieto-Díaz, Abel Crespo, Jhonny Azuaje, Carlos Carbajales, Maria Majellaro, Alejandro Díaz-Holguín, José M Brea, Maria Isabel Loza, Claudia Gioé-Gallo, Marialessandra Contino, Angela Stefanachi, Xerardo García-Mera, Juan C Estévez, Hugo Gutiérrez-de-Terán, Eddy Sotelo. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A 1 Antagonists J Med Chem. 2022 Feb 10;65(3):2091-2106. DOI: 10.1021/acs.jmedchem.1c01636. Epub 2022 Jan 22.

Juan Martín-López, Sandra Codony, Clara Bartra, Christophe Morisseau, María Isabel Loza, Coral Sanfeliu, Bruce D Hammock, José Brea, Santiago Vázquez. 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity Pharmaceuticals (Basel). 2021 Dec 17;14(12):1323.DOI: doi: 10.3390/ph14121323.Indice de impacto: 5.215 (JCR 2020). Q1

Rodriguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Pallàs M, Brocos-Mosquera I, Callado LF, Loza MI, Martínez AL, Brea J, Pérez B, Molins E, De Jonghe S, Daelemans D, Radan M, Djikic T, Nikolic K, Hernández-Hernández E, García-Fuster MJ, García-Sevilla JA, Escolano C. Benzofuranyl-2-imidazoles as imidazoline I 2 receptor ligands for Alzheimer's disease Eur J Med Chem. 2021 Aug 16;225:113779. DOI: 10.1016/j.ejmech.2021.113779. Indice de impacto: 6.514 (JCR 2020). Q1.

Martínez AL, Brea J, Rico S, de Los Frailes MT, Loza MI. Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments Int J Mol Sci. 2021 Sep 14;22(18):9905. DOI: 10.3390/ijms22189905. Indice de impacto: 5.923 (JCR 2020). Q1.

Caterina Pont, Tiziana Ginex, Christian Griñán-Ferré, Matthias Scheiner, Alexia Mattellone, Noemí Martínez, Elsa M Arce, Yolanda Soriano-Fernández, Marina Naldi, Angela De Simone, Marta Barenys, Jesús Gómez-Catalán, Belén Pérez, Raimon Sabate, Vincenza Andrisano, María Isabel Loza, José Brea, Manuela Bartolini, Maria Laura Bolognesi, Michael Decker, Mercè Pallàs, F Javier Luque, Diego Muñoz-Torrero From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects ur J Med Chem. 2021 Aug 16;225:113779. DOI: 10.1016/j.ejmech.2021.113779. Indice de impacto: 6.514 (JCR 2020). Q1.

Alexander G Linan, Jonathan A Myers, Christine E Edwards, Amy E Zanne, Stephen A Smith, Gabriel Arellano, Leslie Cayola, William Farfan-Ríos, Alfredo F Fuentes, Karina García-Cabrera, Sebastián González-Caro, M Isabel Loza, Manuel J Macía, Yadvinder Malhi, Beatriz Nieto-Ariza, Norma Salinas, Miles Silman, J Sebastián Tello The evolutionary assembly of forest communities along environmental gradients: recent diversification or sorting of pre-adapted clades? New Phytol. 2021 Aug 11. DOI: 10.1111/nph.17674. Indice de impacto: 10.151 (JCR 2020). Q1.

Antón L Martínez, José Brea, Eduardo Domínguez, María J Varela, Marta Cimadevila, Catarina Allegue, Raquel Cruz, Xavier Monroy, Manuel Merlos, Javier Burgueño, Ángel Carracedo, M aría I Loza 1 Identification of Novel Regulators of Zalcitabine-Induced Neuropathic Pain Eur J Pharmacol. 2021 Jun 29. DOI: 10.1021/acschemneuro.1c00129.

Pricila Pflüger, Patrícia Pereira, María I Loza, José Brea, Dolores Viña, Amit Kumar, José A Fontenla Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug Eur J Pharmacol. 2021 Sep 5;906:174276. DOI: 10.1016/j.ejphar.2021.174276.

Sergio Rodriguez-Arévalo, Andrea Bagán, Christian Griñán-Ferré, Foteini Vasilopoulou, Mercé Pallás, Iria Brocos-Mosquera, Luis F Callado, M Isabel Loza, Antón L Martínez, José Brea, Belén Pérez, Elies Molins, Steven De Jonghe, Dirk Daelemans, Milica Radan, Teodora Djikic, Katarina Nikolic, Elena Hernández-Hernández, M Julia García-Fuster, Jesús A García-Sevilla, Carmen Escolano Benzofuranyl-2-imidazoles as imidazoline I 2 receptor ligands for Alzheimer's disease Eur J Med Chem. 2021 May 20;222:113540. DOI: 10.1016/j.ejmech.2021.113540.

Isabella Bolognino, Nicola Giangregorio, Annamaria Tonazzi, Antón L Martínez, Cosimo D Altomare, María I Loza, Sara Sablone, Saverio Cellamare, Marco Catto Synthesis and biological evaluation of dantrolene-like hydrazide and hydrazone analogues as multitarget agents for neurodegenerative diseases ChemMedChem. 2021 Sep 16;16(18):2807-2816. DOI: 10.1002/cmdc.202100209.

Carolina Herrero, Jose Brea, Amparo Pérez-Díaz, Emiliano Cuadrado, Noelia Ferreño, Cristian Pablo Moiola, Eva Colás, Antonio Gil-Moreno, Rafael López-López, María Isabel Loza, Miguel Abal, Lorena Alonso-Alconada Modeling ANXA2-overexpressing circulating tumor cells homing and high throughput screening for metastasis impairment in endometrial carcinomas Biomed Pharmacother. 2021 May 25;140:111744. DOI: 10.1016/j.biopha.2021.111744.

Sandra Codony, Carla Calvó-Tusell, Elena Valverde, Sílvia Osuna, Christophe Morisseau, M Isabel Loza, José Brea, Concepción Pérez, María Isabel Rodríguez-Franco, Javier Pizarro-Delgado, Rubén Corpas, Christian Griñán-Ferré, Mercé Pallás, Coral Sanfeliu, Manuel Vázquez-Carrera, Bruce D Hammock, Ferran Feixas, Santiago Vázquez From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis J Med Chem. 2021 May 4. DOI: 10.1021/acs.jmedchem.0c01601.

Ramón Rama-Garda, Jorge Amigo, Julián Priego, Manuel Molina-Martin, Leticia Cano, Eduardo Domínguez, María Isabel Loza, Alfonso Rivera-Sagredo, Jesús de Blas Normalization of DNA encoded library affinity selection results driven by high throughput sequencing and HPLC purification Bioorg Med Chem. 2021 Apr 27. DOI: 10.1016/j.bmc.2021.116178

Ivo E Sampaio-Dias, Ana Reis-Mendes, Vera Marisa Costa, Xerardo García-Mera, José Brea, María Isabel Loza, Beatriz L Pires-Lima, Cristina Alcoholado, Manuel Algarra, José E Rodríguez-Borges Discovery of New Potent Positive Allosteric Modulators of Dopamine D 2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide J Med Chem. 2021 Apr 16. DOI: 10.1021/acs.jmedchem.1c00252

Maria N Barrachina, Ángel García Clinical Proteomics for the Analysis of Circulating Extracellular Vesicles Methods Mol Biol. 2021 MArch 10. DOI: 10.1007/978-1-0716-1178-4_2

Stefanie Kampen, Duy Duc Vo, Xiaoqun Zhang, Nicolas Panel, Yunting Yang, Mariama Jaiteh, Pierre Matricon, Per Svenningsson, Jose Brea, Maria Isabel Loza, Jan Kihlberg, Jens Carlsson Structure-guided Design of G Protein-coupled Receptor Polypharmacology Angew Chem Int Ed Engl. 2021 Apr 27. DOI: 10.1002/anie.202101478

Eleyna M Martin, Malou Zuidscherwoude, Luis A Morán, Ying Di, Angel García, Steve P Watson. The structure of CLEC-2: mechanisms of dimerization and higher-order clustering Platelets. 2021 Apr 5. DOI: 10.1080/09537104.2021.1906407

Attila Egyed, Ádám A Kelemen, Márton Vass, András Visegrády, Stephanie A Thee, Zhiyong Wang, Chris de Graaf, Jose Brea, Maria Isabel Loza, Rob Leurs, György M Keserű. Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule Bioorg Chem. 2021 Mar 19. DOI: 10.1016/j.bioorg.2021.104832

Agnieszka A Kaczor, Katarzyna M Targowska-Duda, Piotr Stępnicki, Andrea G Silva, Oliwia Koszła, Ewa Kędzierska, Angelika Grudzińska, Marta Kruk-Słomka, Grażyna Biała, Marián Castro. N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: in vitro, in silico and in vivo evaluation of a multi-target ligand Neurochem Int. 2021 Mar 12. DOI: 10.1016/j.neuint.2021.105016

Enza Lacivita, Mauro Niso, Margherita Mastromarino, Andrea Garcia Silva, Cibell Resch, Andre Zeug, María I Loza, Marián Castro, Evgeni Ponimaskin, Marcello Leopoldo. Knowledge - Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder ACS Chem Neurosci. 2021 Apr 1. DOI: 10.1021/acschemneuro.0c00647

María N. Barrachina,Irene Izquierdo, Lidia Hermida-Nogueira,Luis A. Morán,Amparo Pérez,Ana B. Arroyo,Nuria García-Barberá,Rocío González-Conejero,Sara Troitiño,Johannes A. Eble,José Rivera,Constantino Martínez,María I. Loza,Eduardo Domínguez and Ángel García. The PI3Kd Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential Int. J. Mol. Sci. 2021, 22(7), 3304; DOI: https://doi.org/10.3390/ijms22073304

Antón L Martínez, José Brea, Mateo Barro, Xavier Monroy, Manuel Merlos, Javier Burgueño, María Isabel Loza Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening PLoS One. 2021 Mar 10;16(3):e0248139. DOI: 10.1371/journal.pone.0248139..

Elena Bechthold, Julian A Schreiber, Kirstin Lehmkuhl, Bastian Frehland, Dirk Schepmann, Freddy A Bernal, Constantin Daniliuc, Inés Álvarez, Cristina Val Garcia, Thomas J Schmidt, Guiscard Seebohm, Bernhard Wünsch Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity J Med Chem. 2021 Jan 28;64(2):1170-1179. Epub 2021 Jan 10 DOI: 10.1021/acs.jmedchem.0c01912.

Sandra M.Martín-Guerrero, Paula Alonso, Alba Iglesias, Marta Cimadevila, José Brea, M.Isabel Loza, PedroCasado, DavidMartín-Oliva, Pedro R.Cutillas, JavierGonzález-Maeso, Juan F.López-Giménez His452Tyr Polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics Biochemical Pharmacology. 2021 Mar;185:114440. DOI: 10.1016/j.bcp.2021.114440.

María N Barrachina, Lidia Hermida-Nogueira, Luis A Moran, Vanessa Casas, Sarah M Hicks, Aurelio M Sueiro, Ying Di, Robert K Andrews, Steve P Watson, Elizabeth E Gardiner, Joaquin Abian, Montserrat Carrascal, María Pardo, Ángel García. Phosphoproteomic Analysis of Platelets in Severe Obesity Uncovers Platelet Reactivity and Signaling Pathways Alterations Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):478-490. DOI: 10.1161/ATVBAHA.120.314485.

Foteini-Nafsika Damaskinaki, Luis A Morán, Angel García, Barrie Kellam, Steve P Watson. Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2 ACS Chem Neurosci. 2021 Jan 7. DOI: 10.1080/09537104.2020.1863939. Online ahead of print.

Ivo E Sampaio-Dias, José E Rodríguez-Borges, Víctor Yáñez-Pérez, Sonia Arrasate, Javier Llorente, José M Brea, Harbil Bediaga, Dolores Viña, María Isabel Loza, Olga Caamaño, Xerardo García-Mera, Humberto González-Díaz. Synthesis, Pharmacological, and Biological Evaluation of 2-Furoyl-Based MIF-1 Peptidomimetics and the Development of a General-Purpose Model for Allosteric Modulators (ALLOPTML) ACS Chem Neurosci. 2021 Jan 6;12(1):203-215. DOI: 10.1021/acschemneuro.0c00687. Online ahead of print.

Serena Massari, Chiara Bertagnin, Maria Chiara Pismataro, Anna Donnadio, Giulio Nannetti, Tommaso Felicetti, Stefano Di Bona, Maria Giulia Nizi, Leonardo Tensi, Giuseppe Manfroni, Maria Isabel Loza, Stefano Sabatini, Violetta Cecchetti, Jose Brea, Laura Goracci, Arianna Loregian, Oriana Tabarrini Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase Eur J Med Chem. 2021 Jan 1;209:112944. DOI: 10.1016/j.ejmech.2020.112944. Epub 2020 Oct 16.

Jorge Lozano-Juste, Irene García-Maquilón, José Brea, Rocío Piña, Armando Albert, Pedro L Rodriguez, María Isabel Loza Identification of ABA Receptor Agonists Using a Multiplexed High-Throughput Chemical Screening Methods Mol Biol. 2021;2213:99-111. DOI: 10.1007/978-1-0716-0954-5_9.

María Majellaro, Willem Jespers, Abel Crespo, María J Núñez, Silvia Novio, Jhonny Azuaje, Rubén Prieto-Díaz, Claudia Gioé, Belma Alispahic, José Brea, María I Loza, Manuel Freire-Garabal, Carlota García-Santiago, Carlos Rodríguez-García, Xerardo García-Mera, Olga Caamaño, Christian Fernández-Masaguer, Javier F Sardina, Angela Stefanachi, Abdelaziz El Maatougui, Ana Mallo-Abreu, Johan Åqvist, Hugo Gutiérrez-de-Terán, Eddy Sotelo. 3,4-Dihydropyrimidin-2(1 H)-ones as Antagonists of the Human A 2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition J Med Chem. 2021 Jan 14;64(1):458-480. 2020 Dec 29. DOI: 10.1021/acs.jmedchem.0c01431.

Elia Álvarez-Coiradas, Cristian R Munteanu, Laura Díaz-Sáez, Alejandro Pazos, Kilian V M Huber, María Isabel Loza, Eduardo Domínguez. Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway Int Immunopharmacol. 2020 Oct 9;89(Pt A):107026. DOI: : 10.1016/j.intimp.2020.107026.

Lidia Hermida-Nogueira, María N Barrachina, Luis A Morán, Susana Bravo, Pedro Diz, Ángel García, Juan Blanco Deciphering the secretome of leukocyte-platelet rich fibrin: towards a better understanding of its wound healing properties. Sci Rep. 2020 Sep 3;10(1):14571. DOI: 10.1038/s41598-020-71419-7.

Sandra Codony, Eugénia Pujol, Javier Pizarro, Ferran Feixas, Elena Valverde, M Isabel Loza, José M Brea, Elena Saez, Julen Oyarzabal, Antonio Pineda-Lucena, Belén Pérez, Concepción Pérez, María Isabel Rodríguez-Franco, Rosana Leiva, Sílvia Osuna, Christophe Morisseau, Bruce D Hammock, Manuel Vázquez-Carrera, Santiago Vázquez 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. J Med Chem. 2020 Sep 10;63(17):9237-9257. DOI: 10.1021/acs.jmedchem.0c00310. Online ahead of print.

F Javier Pérez-Areales, María Garrido, Ester Aso, Manuela Bartolini, Angela De Simone, Alba Espargaró, Tiziana Ginex, Raimon Sabate, Belén Pérez, Vincenza Andrisano, Dolors Puigoriol-Illamola, Mercé Pallás, F Javier Luque, María Isabel Loza, José Brea, Isidro Ferrer, Francisco Ciruela, Angel Messeguer, Diego Muñoz-Torrero Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6. J Med Chem. 2020 Sep 10;63(17):9360-9390. DOI: 110.1021/acs.jmedchem.0c00528. Epub 2020 Aug 11.

María N Barrachina, Luis A Morán, Irene Izquierdo, Felipe F Casanueva, María Pardo, Ángel García Analysis of platelets from a diet-induced obesity rat model: elucidating platelet dysfunction in obesity. J Med Chem. 2020 Aug 4;10(1):13104. DOI: 10.1038/s41598-020-70162-3.

Uxía Nogueira-Recalde, Irene Lorenzo-Gómez, María I Loza, Eduardo Domínguez, Beatriz Caramés . Flux-Based Assay for the Identification of Autophagy Modulators for Osteoarthritis. J Vis Exp. 2020 Jul 8;(161). DOI: 10.3791/61078.

Ana Mallo-Abreu, Ruben Prieto-Diaz, Willem Jespers, Jhonny Azuaje, Maria Majellaro, Carmen Velando, Xerardo García-Mera, Olga Caamaño, José M Brea, María Isabel Loza, Hugo Gutiérrez-de-Terán, Eddy Sotelo. Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists. J Med Chem. 2020 Jul 23. DOI: 10.1021/acs.jmedchem.0c00564.

Christian Griñán-Ferré, Sandra Codony, Eugènia Pujol, Jun Yang, Rosana Leiva, Carmen Escolano, Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Rubén Corpas, Coral Sanfeliu, Belen Pérez, M Isabel Loza, José Brea, Christophe Morisseau, Bruce D Hammock, Santiago Vázquez, Mercè Pallàs, Carles Galdeano. Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease . Neurotherapeutics. 2020 Jun 2. DOI: 10.1007/s13311-020-00854-1.

M Cimadevila, L Gómez-García, A L Martínez, A Iglesias, J López-Giménez, M Castro, M I Cadavid, M I Loza, J Brea. Essential Role of the C148-C227 Disulphide Bridge in the Human 5-HT 2A Homodimeric Receptor . Biochem Pharmacol. 2020 Jul;177:113985. DOI: 10.1016/j.bcp.2020.113985.

Júlia Companys-Alemany, Andreea L Turcu, Aina Bellver-Sanchis, Maria I Loza, José M Brea, Anna M Canudas, Rosana Leiva, Santiago Vázquez, Mercé Pallás, Christian Griñán-Ferré. A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice . Pharmaceutics. 2020 Mar 22 DOI: 10.3390/pharmaceutics12030284.

Sonia Abás, Sergio Rodríguez-Arévalo, Andrea Bagán, Christian Griñán-Ferré, Foteini Vasilopoulou, Iria Brocos-Mosquera, Carolina Muguruza, Belén Pérez, Elies Molins, F Javier Luque, Pilar Pérez-Lozano, Steven De Jonghe, Dirk Daelemans, Lieve Naesens, José M Brea, María Isabel Loza, Elena Hernández-Hernández, Jesús A García-Sevilla, M Julia Dr García-Fuster, Milica Radan, Teodora Djikic, Katarina Nikolic, Mercé Pallás, Luis F Callado. Bicyclic -Iminophosphonates as Highly Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease. J Med Chem. 2020 Mar 9[Online ahead of print] DOI: 10.021/acs.jmedchem.9b02080.

Agnieszka A Kaczor, Katarzyna M Targowska-Duda, Andrea G Silva, Magda Kondej, Grażyna Biała, Marián Castro. N-(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1 H-benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic. Biomolecules. 10 (2) 2020 Feb 24 DOI: 10.3390/biom10020349.

Thirumal Yempala, José Brea, María Isabel Loza, Douglas J Matthies, Gerald Zapata-Torres, Bruce K Cassels. Dibenzofuranylethylamines as 5-HT 2A/2C Receptor Agonists. ACS Omega. 5 (5), 2260-2266 2020 Feb 11 DOI: 10.1021/acsomega.9b03430.

Triana F, Loza MI, Domínguez E. Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy. Cells. 9 (2). 2020 Feb 3 DOI: 10.3390/cells9020346.

Joanne L Dunster, Amanda J Unsworth, Alexander P Bye, Elizabeth J Haining, Marcin A Sowa, Ying Di, Tanya Sage, Chiara Pallini, Jeremy A Pike, Alexander T Hardy, Bernhard Nieswandt, Ángel García, Steve P Watson, Natalie S Poulter, Jonathan M Gibbins, Alice Y Pollitt. Interspecies Differences in Protein Expression Do Not Impact the Spatiotemporal Regulation of Glycoprotein VI Mediated Activation. J Thromb Haemost. 18 (2), 485-496 Feb 2020 DOI: 10.1111/jth.146739.

López Iglesias, C., Barros J., Ardao I., Gurikov P.,Monteiro F., Smirnova I., Alvarez Lorenzo C. and García González C.. Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin. Polymers. 2020, 12, 273. DOI: 10.3390/polym12020273.

Andrea G Silva, Laura Vila, Patrice Marques, Laura Moreno, Mabel Loza, María-Jesús Sanz, Diego Cortes, Marián Castro, Nuria Cabedo. 1-(2'-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D 2 Dopamine Receptors. J Nat Prod. 2020 Jan 24. DOI: 10.1021/acs.jnatprod.9b00921.

Samaridou E, Walgrave H, Salta E, Álvarez DM, Castro-López V, Loza M, Alonso MJ. Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases. Biomaterials. 2020 Feb. DOI: 10.1016/j.biomaterials.2019.119657.

Ballante F, Rudling A, Zeifman A, Luttens A, Vo DD, Irwin JJ, Kihlberg J, Brea JM, Loza MI, Carlsson J. Docking finds GPCR ligands in dark chemical matter. J Med Chem. 2020 Jan 23. DOI: 10.1021/acs.jmedchem.9b01560.

Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Morán LA, Lacerenza S, Pinto-Llorente R, Eble JA, de Los Ríos V, Domínguez E, Loza MI, Casal JI, Carrascal M, Abián J, García A. A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade. Thromb Haemost. 2020 Feb. DOI: 10.1055/s-0039-3400295. [Epub ahead of print].

Spinelli F, Giampietro R, Stefanachi A, Riganti C, Kopecka J, Abatematteo F, Leonetti F, Colabufo N, Mangiatordi G, Nicolotti O, Perrone M, Brea J, Loza MI, Infantino V, Abate C, Contino M. Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor CB2R). Eur J Med Chem. 2020 Jan 7. DOI: 10.1016/j.ejmech.2020.112037.

Magli E, Severino B, Corvino A, Perissutti E, Frecentese F, Saccone I, Giordano F, Castro M, Brea J, Loza MI, Santagada V, Caliendo G, Fiorino F. New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and in Vitro Pharmacological Evaluation. Med Chem. 2020;16(4):517-530.. DOI: 10.2174/1573406415666190613153220.

Lidia Hermida-Nogueira, María N Barrachina, Irene Izquierdo, María García-Vence, Serena Lacerenza, Susana Bravo, Azucena Castrillo, Ángel García. Proteomic Analysis of Extracellular Vesicles Derived From Platelet Concentrates Treated With Mirasol® Identifies Biomarkers of Platelet Storage Lesion. J Proteomics. 2020 Jan 6. DOI: 10.1016/j.jprot.2019.103529.

Aragó M, Moreno-Felici J, Abás S, Rodríguez-Arévalo S, Hyroššová P, Figueras A, Viñals F, Pérez B, Loza MI, Brea J, Latorre P, Carrodeguas JA, García-Rovés PM, Galdeano C, Ginex T, Luque FJ, Escolano C, Perales JC. Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M. Biomed Pharmacother. 2020 Jan;121:109601. DOI: 10.1016/j.biopha.2019.109601.

O Salas C, Zarate AM, Kryštof V, Mella J, Faundez M, Brea J, Loza MI, Brito I, Hendrychová D, Jorda R, Cabrera AR, Tapia RA, Espinosa-Bustos C. Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays. Int J Mol Sci. 2019 Dec 25. DOI: 10.3390/ijms21010161.

Astolfi A, Kudolo M, Brea J, Manni G, Manfroni G, Palazzotti D, Sabatini S, Cecchetti F, Felicetti T, Cannalire R, Massari S, Tabarrini O, Loza MI, Fallarino F, Cecchetti V, Laufer SA, Barreca ML. Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation. Eur J Med Chem. 2019 Nov 15. DOI: 10.1016/j.ejmech.2019.111624. Epub 2019 Aug 16

Triana-Martínez F, Picallos-Rabina P, Da Silva-Álvarez S, Pietrocola F, Llanos S, Rodilla V, Soprano E, Pedrosa P, Ferreirós A, Barradas M, Hernández-González F, Lalinde M, Prats N, Bernadó C, González P, Gómez M, Ikonomopoulou MP, Fernández-Marcos PJ, García-Caballero T, Del Pino P, Arribas J, Vidal A, González-Barcia M, Serrano M, Loza MI, Domínguez E, Collado M. Identification and characterization of Cardiac Glycosides as senolytic compounds. Nat Commun. 2019 Oct 21;10(1):4731. DOI: 10.1038/s41467-019-12888-x.

Mallo-Abreu A, Majellaro M, Jespers W, Azuaje J, Caamaño O, García-Mera X, Brea JM, Loza MI, Gutiérrez de Terán H, Sotelo E.. Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidences of Stereospecific Recognition. J Med Chem. 2019 Oct 24. DOI: 10.1021/acs.jmedchem.9b01340. [Epub ahead of print]

Codony S, Valverde E, Leiva R, Brea J, Loza MI, Morisseau C, Hammock B, Vázquez S. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorg Med Chem. 2019 Oct 15; 27 (20), 115078. DOI: 10.1016/j.bmc.2019.115078.

Sampaio-Dias IE, Silva-Reis SC, García-Mera X, Brea JM, Loza MI, Alves C, Algarra M, Rodríguez-Borges JE. Synthesis, Pharmacological and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R. ACS Chem Neurosci. 2019 Aug 7. DOI: 0.1021/acschemneuro.9b00259. 2019 Aug 21

Kondej M, Wróbel TM, Silva AG, Stępnicki P, Koszła O, Kędzierska E, Bartyzel A, Biała G, Matosiuk D, Loza MI, Castro M, Kaczor AA. Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs. Eur J Med Chem. 2019 Oct 15. DOI: 10.1016/j.ejmech.2019.07.050. [Epub ahead of print]

Nogueira-Recalde U, Lorenzo-Gómez I, Blanco FJ, Loza MI, Grassi D, Shirinsky V, Shirinsky I, Lotz M, Robbins PD, Domínguez E, Caramés B. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy. EBioMedicine. 2019 Jul 5. DOI: 10.1016/j.ebiom.2019.06.049. [Epub ahead of print]

Areias F, Correia C, Rocha A, Brea J, Castro M, Loza MI, Proença MF, Carvalho MA. 2-Aryladenine derivatives as a potent scaffold for A₁, A₃ and dual A₁/A₃ adenosine receptor antagonists: Synthesis and structure-activity relationships. Bioorg Med Chem. 2019 Aug 15. DOI: 10.1016/j.bmc.2019.06.034. Epub 2019 Jun 20.

Caruncho HJ., Kalynchuk LE., Loza MI. and Olivares JM. Editorial: Novel Approaches to the Neuropharmacology of Mood Disorders Front. Pharmacol. 2019 May 17; 10:589. DOI: 10.3389/fphar.2019.00589. Epub 17 May 2019

Calviño-Sampedro C, Gomez-Touriño I, Cordero OJ, Reche PA, Gómez-Perosanz M, Sánchez-Trincado JL, Rodríguez MÁ, Sueiro AM, Viñuela JE, Calviño RV. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes. FASEB J. 2019 May;33(5):6390-6401. DOI: 10.1096/fj.201802270R. Epub 2019 Feb 28.

Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Eble JA, Carrascal M, Abián J, García Á. Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation. J Proteomics. 2019 Mar 20;195:88-97. DOI: 10.1016/j.jprot.2019.01.014. Epub 2019 Jan 22.

Santos-Rosales V., Ardao I., Alvarez-Lorenzo C., Ribeiro N., Oliveira A. and García-González CA. Sterile and Dual-Porous Aerogels Scaffolds Obtained through a Multistep Supercritical CO2-Based Approach. Molecules 2019, 24(5), 871; DOI: 10.3390/molecules24050871. Epub 2019 Mar 1.

María N Barrachina, Irene Izquierdo, Lidia Hermida-Nogueira, Aurelio M Sueiro, Esteban Guitián, Felipe F Casanueva, Richard W Farndale, Masaaki Moroi, Stephanie M Jung, María Pardo, Ángel García Data on Hyper-Activation of GPVI Signalling in Obese Patients: Towards the Identification of Novel Antiplatelet Targets in Obesity. Data Brief. 2019 Feb 28 eCollection Apr 2019. DOI: 10.1016/j.dib.2019.103784. .

Martínez AL., Brea J., Monroy X., Merlos M., Burgueño J., Loza MI. A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropathic Pain. SLAS Discov. 2019 Feb;24(2):158-168. DOI: 10.1177/2472555218810323. Epub 2018 Nov 1.

María N Barrachina, Aurelio M Sueiro, Irene Izquierdo, Lidia Hermida-Nogueira, Esteban Guitián, Felipe F Casanueva, Richard W Farndale, Masaaki Moroi, Stephanie M Jung, María Pardo, Ángel García. GPVI Surface Expression and Signalling Pathway Activation Are Increased in Platelets From Obese Patients: Elucidating Potential Anti-Atherothrombotic Targets in Obesity. Atherosclerosis. 62-70 Feb 2019. DOI: 10.1016/j.atherosclerosis.2018.12.023.

Barrachina MN., Calderón-Cruz B., Fernandez-Rocca L., García Á. Application of Extracellular Vesicles Proteomics to Cardiovascular Disease: Guidelines, Data Analysis, and Future Perspectives. Proteomics. 2019 Jan;19(1-2):e1800247. DOI: 10.1002/pmic.201800247. Epub 2019 Jan 7.

Barrachina MN., Sueiro AM., Casas V., Izquierdo I., Hermida-Nogueira L., Guitián E., Casanueva FF., Abián J., Carrascal M., Pardo M., García Á. A Combination of Proteomic Approaches Identifies A Panel of Circulating Extracellular Vesicle Proteins Related to the Risk of Suffering Cardiovascular Disease in Obese Patients. Proteomics. 2019 Jan;19(1-2):e1800248. DOI: 10.1002/pmic.201800248. Epub 2018 Dec 7:e1800248.

López-Iglesias C., Barros J., Ardao I., Monteiro FJ., Alvarez-Lorenzo C., Gómez-Amoza JL., García-González CA. Vancomycin-loaded chitosan aerogel particles for chronic wound applications. Carbohydr Polym. 2019 Jan 15;204:223-231. DOI: 10.1016/j.carbpol.2018.10.012. Epub 2018 Oct 9.

Pérez-Mato M., Iglesias-Rey R., Vieites-Prado A., Dopico-López A., Argibay B., Fernández-Susavila H., Da Silva-Candal A., Pérez-Díaz A., Correa-Paz C., Günther A., Ávila-Gómez P., Isabel Loza M., Baumann A., Castillo J., Sobrino T., Campos F. Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia. EBioMedicine. 2019 Jan;39:118-131. DOI: 10.1016/j.ebiom.2018.11.024. Epub 2018 Dec 13.

Toro-Sazo M., Brea J., Loza MI., Cimadevila M., Cassels BK. 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines. PLoS One. 2019 Jan 10;14(1):e0209804. DOI: 10.1371/journal.pone.0209804. eCollection 2019.

Brennecke P., Rasina D., Aubi O., Herzog K., Landskron J., Cautain B., Vicente F., Quintana J., Mestres J., Stechmann B., Ellinger B., Brea J., Kolanowski JL., Pilarski R., Orzaez M., Pineda-Lucena A., Laraia L., Nami F., Zielenkiewicz P., Paruch K., Hansen E., Von Kries JP., Neuenschwander M., Specker E., Bartunek P., Simova S., Leśnikowski Z., Krauss S., Lehtiö L., Bilitewski U., Brönstrup M., Taskén K., Jirgensons A., Lickert H., Clausen MH., Andersen JH., Vicent MJ., Genilloud O., Martinez A., Nazaré M., Fecke W., Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discov. 2019 Mar:2472555218816276. DOI: 10.1177/2472555218816276. Epub 2019 Jan 7.

Bettencourt AP, Castro M, Silva JP, Fernandes F, Coutinho OP, Sousa MJ, Proença MF, Areias FM. Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship. Med Chem. 2019;15(4):341-351. DOI: 10.2174/1573406414666181005143431.

Ramos A., Rodríguez-Seoane C., Rosa I., Gorroño-Etxebarria I., Alonso J., Veiga S., Korth C., Kypta RM., García Á., Requena JR. Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function. Int J Mol Sci. 2018 Dec 29;20(1). pii: E119. DOI: 10.3390/ijms20010119.

Ferreira da Costa J., Silva D., Caamaño O., Brea JM., Loza MI., Munteanu CR., Pazos A., García-Mera X., González-Díaz H. Perturbation Theory/Machine Learning Model of ChEMBL Data for Dopamine Targets: Docking, Synthesis, and Assay of New l-Prolyl-l-leucyl-glycinamide Peptidomimetics. ACS Chem Neurosci. 2018 Nov 21. DOI: 10.1021/acschemneuro.8b00083. Epub 2018 Jun 25.

Ruiz-De Diego I., Fasano S., Solís O., García-Montes JR., Brea J., Loza MI., Brambilla R., Moratalla R. Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin. Sci Rep.2018 Oct 18;8(1):15381. DOI: 10.1038/s41598-018-33713-3.

Bettencourt A, Castro M, Silva J, Fernandes F, Coutinho O, Sousa MJ, Proença MF, Areias F. New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure⁻Activity Relationship. Molecules. 2018 Oct 3;23(10). pii: E2530. DOI: 10.3390/molecules23102530.

Kondej M, Bartyzel A, Pitucha M, Wróbel TM, Silva AG, Matosiuk D, Castro M, Kaczor AA. Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D₂ Receptor Ligand. Molecules. . 2018 Sep 4;23(9). pii: E2249. DOI: 10.3390/molecules23092249.

Da Silva-Candal A., Pérez-Díaz A., Santamaría M., Correa-Paz C., Rodríguez-Yáñez M., Ardá A., Pérez-Mato M., Iglesias-Rey R., Brea J., Azuaje J., Sotelo E., Sobrino T., Loza MI., Castillo J, Campos F. Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke. Ann Neurol. 2018 Aug;84(2):260-273. DOI: 10.1002/ana.25286. Epub 2018 Aug 22.

Zamora-Sequeira, R., Ardao, I., Starbird, R., García-González, CA. Conductive nanostructured materials based on poly-(3,4-ethylenedioxythiophene) (PEDOT) and starch/κ-carrageenan for biomedical applications. Carbohydr Polym. 2018 Jun 1;189:304-312. DOI: 10.1016/j.carbpol.2018.02.040. Epub 2018 Feb 14

Jaiteh M., Zeifman A., Saarinen M., Svenningsson P., Brea JM., Loza MI., Carlsson J. Docking screens for dual inhibitors of disparate drug targets for Parkinson's disease. J Med Chem. 2018 Jun 28. DOI: 10.1021/acs.jmedchem.8b00204. Epub 2018 Jun 15.

Amigo J., Rama-Garda R., Bello X., Sobrino B., De Blas J., Martín-Ortega M., Jessop TC., Carracedo Á., Loza MI., Domínguez E. TagFinder: A Novel Tag Analysis Methodology That Enables Detection of Molecules from DNA-Encoded Chemical Libraries. SLAS Discov. 2018 Jun; 23(5):397-404. DOI: 10.1177/2472555217753840. Epub 2018 Jan 23.

Rataj K., Kelemen ÀA., Brea J., Loza MI., Bojarski AJ., Keserű GM. Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands. Molecules. 2018 May 10;23(5). pii: E1137. DOI: 10.3390/molecules23051137

Miret-Casals L., Sebastián D., Brea J., Rico-Leo EM., Palacín M., Fernández-Salguero PM., Loza MI., Albericio F., Zorzano A.. Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism. Cell Chem Biol. 2018 Mar 15. pii: S2451-9456(17)30428-2. DOI: 10.1016/j.chembiol.2017.12.001. Epub 2017 Dec 28.

Goimil, L., Jaeger, P., Ardao, I., Gómez-Amoza JL., Concheiro, A., Álvarez-Lorenzo C., García-González, CA. Preparation and stability of dexamethasone-loaded polymeric scaffolds for bone regeneration processed by compressed CO2 foaming( Journal of CO2 Utilization. 2018 Mar; 24, pp. 89-98. DOI: 10.1016/j.jcou.2017.12.012. Epub 2017 Dec 26.

Nkizinkiko Y., Desantis J., Koivunen J., Haikarainen T., Murthy S., Sancineto L., Massari S., Ianni F., Obaji E., Loza MI., Pihlajaniemi T., Brea J., Tabarrini O., Lehtiö L. 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep. 2018 Jan 26;8(1):1680. DOI: 10.1038/s41598-018-19872-3.

Kalash L., Val C., Azuaje J., Loza MI., Svensson F., Zoufir A., Mervin L., Ladds G., Brea J., Glen R., Sotelo E., Bender A. Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases. J Med Chem. 2017 Dec 30;9(1):67. DOI: 10.1186/s13321-017-0249-4.

García Cárceles J., Decara JM., Vázquez-Villa H., Rodríguez R., Codesido E., Cruces J., Brea JM., Loza MI., Alén F., Botta J., McCormick PJ., Ballesteros JA., Benhamú B., Rodríguez De Fonseca F., López-RodríGuez ML. A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. J Med Chem. 2017 Dec 14;60(23):9575-9584. DOI: 10.1021/acs.jmedchem.7b00994. Epub 2017 Nov 17.

Burgueño J., Pujol M., Monroy X., Roche D., Varela MJ., Merlos M., Giraldo J. A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses. Scientific Reports. 2017 Nov 13;7(1):15389. DOI: 10.1038/s41598-017-15258-z.

Iglesias A., Cimadevila M., La Fuente RA., Martí-Solano M., Cadavid MI., Castro M., Selent J., Loza MI., Brea J. Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization. Eur J Pharmacol. 2017 Nov 15;815:138-146. DOI: 10.1016/j.ejphar.2017.09.011. Epub 2017 Sep 9.

Varela MJ., Acanda De La Rocha AM., Díaz A. Potentiation of morphine-induced antinociception and locomotion by citalopram is accompanied by anxiolytic-like effects. Pharmacology Biochemistry and Behavior. Dec 2017; 163, pp. 83 - 89. DOI: 10.1016/j.pbb.2017.10.003. Epub 2017 Oct 10.

Akhter S., Chakraborty S., Moutinho D., álvarez-Coiradas E., Rosa I., Viñuela J., Domínguez E., García A., Requena JR. The human VGF-derived bioactive peptide TLQP-21 binds heat shock 71 kDa protein 8 (HSPA8)on the surface of SH-SY5Y cells. PLoS One. 2017 Sep 21;12(9):e0185176. DOI: 10.1371/journal.pone.0185176. eCollection 2017.

Azuaje J., López P., Iglesias A., De La Fuente RA., Pérez-Rubio JM., García D., Stepniewski TM., García-Mera X., Brea JM., Selent J., Pérez D., Castro M., Loza MI., Sotelo E. Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors. Sci Rep. 2017 Sep 7;7(1):10765. DOI: 10.1038/s41598-017-11370-2.

El Maatougui A., Yañez M., Crespo A., Fraiz N., Coelho A ., Raviña E., Laguna R., Cano E., Loza MI. , Brea J. , Gutierrez de Teran H., Sotelo E. 3-Oxopyridazin-5-yl-Chalcone Hybrids: Potent Antiplatelet Agents That Prevent Glycoprotein IIb/IIIa Activation ChemistrySelect. 2017 June 19: 17(2):4920-4933. DOI: 10.1002/slct.201700243. Epub 2017 Sept 10.

García AM, Brea J, González-García A, Pérez C, Cadavid MI, Loza MI, Martinez A, Gil C. Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects. Molecules. 2017 Sep 4;22(9). DOI: 10.3390/molecules22091472.

Azuaje J., Jespers W., Yaziji V., Mallo A., Majellaro M., Caamaño O., Loza MI., Cadavid MI., Brea J., Åqvist J., Sotelo E., Gutiérrez-de-Terán H. Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists. J Med Chem. 2017 Sep 14;60(17):7502-7511. DOI: 10.1021/acs.jmedchem.7b00860. Epub 2017 Aug 21.

Kumar R., Yadav N., Lavilla R., Blasi D., Quintana J., Brea JM., Loza MI., Mestres J., Bhandari M., Arora R., Kakkar R., Prasad AK. Synthesis, pharmacological evaluation and molecular docking of pyranopyrazole-linked 1,4-dihydropyridines as potent positive inotropes. Mol Divers. 2017 Aug;21(3):533-546. DOI: 10.1007/s11030-017-9738-7. Epub 2017 Apr 25.

García AM., Salado IG., Pérez DI., Brea J., Morales-García JA., González-García A., Cadavid MI., Loza MI., Luque FJ., Pérez-Castillo A., Martínez A., Gil C. Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease. Future Med Chem. 2017 May 9. DOI: 10.4155/fmc-2017-0005. Epub 2017 May 9.

Rodríguez-Vázquez N., García-Fandiño R., Aldegunde MJ., Brea J., Loza MI., Amorín M., Granja JR. Cis-Platinum Complex Encapsulated in Self-Assembling Cyclic Peptide Dimers. Org Lett. 2017 May 19;19(10):2560-2563. DOI: 10.1021/acs.orglett.7b00871. Epub 2017 May 4.

Carbajales C., Azuaje J., Oliveira A., Loza MI., Brea JM., Cadavid MI., Masaguer CF., García-Mera X., Gutiérrez-de-Terán H., Sotelo E. Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates. J Med Chem. 2017 Apr 27;60(8):3372-3382. DOI: 10.1021/acs.jmedchem.7b00138. Epub 2017 Apr 11.

Crespo A., El Maatougui A., Azuaje J., Escalante L., Majellaro M., Loza MI., Brea, J., Cadavid MI., Gutierrez-de-Teran, H., Sotelo E. Exploring the influence of the substituent at position 4 in a series of 3,4-dihydropyrimidin-2(1H)-one A(2B) adenosine receptor antagonists. Chemistry of Heterocyclic Compounds 2017 mar; 53 (3): 316-321 ISSN: 0009-3122. DOI: 10.1007/s10593-017-2054-4.

Iglesias A., Cimadevila M., Cadavid MI., Loza MI., Brea J. Serotonin-2A homodimers are needed for signalling via both phospholipase A2 and phospholipase C in transfected CHO cells. Eur J Pharmacol. 2017 Apr 5;800:63-69. DOI: 10.1016/j.ejphar.2017.02.028. Epub 2017 Feb 17.

Vélez P., Ocaranza-Sánchez R., López-Otero D., Grigorian-Shamagian L., Rosa I., Guitián E., García-Acuña JM., Gonzá lez-Juanatey JR., García Á. Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches. Sci Rep. 2016 Dec 22;6:39603. DOI: 10.1038/srep39603.

Izquierdo I., García A. Platelet proteomics applied to the search for novel antiplatelet therapeutic targets. Expert Rev Proteomics. Expert Rev Proteomics. 2016 Nov. DOI: 10.1080/14789450.2016.1246188. Epub 2016 Oct 20.

Izquierdo I., Rosa I., Bravo SB., Guitián E., Pérez-Serra A., Campuzano O., Brugada R., Mangas A., García Á., Toro R. Proteomic identification of putative biomarkers for early detection of sudden cardiac death in a family with a LMNA gene mutation causing dilated cardiomyopathy. J Proteomics. 2016 Oct 4;148:75-84. DOI: 10.1016/j.jprot.2016.07.020. Epub 2016 Jul 22.

Castillo J., Loza MI., Mirelman D., Brea J., Blanco M., Sobrino T., Campos F. A novel mechanism of neuroprotection: Blood glutamate grabber. J Cereb Blood Flow Metab. 2016 Feb;36(2):292-301. DOI: 10.1177/0271678X15606721. Epub 2015 Oct 2.

Salvadó I.; Gamba I., Montenegro J., Martínez-Costas J., Brea JM., Loza MI., Vázquez López M. and Vázquez ME. Membrane-disrupting iridium(III) oligocationic organometallopeptides Med. Chem. Commun. 2016 Sept 21;52(73): 11008-11011. DOI: 10.1039/C6CC05537K. Epub 2016 Aug 19.

Iglesias A., Lage S., Cadavid MI., Loza MI., Brea J. Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening J Biomol Screen. 2016 Sep;21(8):816-23. DOI: 10.1177/1087057116644162. Epub 2016 Apr 19.

García A. Platelet Clinical Proteomics: Facts, challenges and future perspectives. Proteomics Clin. Appl. 2016 Aug;10(8):767-73. DOI: 10.1002/prca.201500125. Epub 2016 Mar 31.

Vélez P., Ocaranza-Sánchez R., López-Otero D., Grigorian-Shamagian L., Rosa I., Bravo SB., González-Juanatey JR., García A. 2D-DIGE-based proteomic analysis of intracoronary versus peripheral arterial blood platelets from acute myocardial infarction patients: upregulation of platelet activation biomarkers at the culprit site. Proteomics Clin. Appl. 2016 Aug;10(8):851-8. DOI: 10.1002/prca.201500120. Epub 2016 May 23.

Van Voorhis WC., Adams JH., Adelfio R., Ahyong V., Akabas MH., Alano P., Alday A., Alemán Resto Y., Alsibaee A., Alzualde A., Andrews KT., Avery SV., Avery VM., Ayong L., Baker M., Baker S., Ben Mamoun C., Bhatia S., Bickle Q., Bounaadja L., Bowling T., Bosch J., Boucher LE., Boyom FF., Brea J., Brennan M., Burton A., Caffrey CR., Camarda G., Carrasquilla M., Carter D., Belen Cassera M., Chih-Chien Cheng K., Chindaudomsate W., Chubb A., Colon BL., Colón-López DD., Corbett Y., Crowther GJ., Cowan N., D'Alessandro S., Le Dang N., Delves M., DeRisi JL., Du AY., Duffy S., Abd El-Salam El-Sayed S., Ferdig MT., Fernández Robledo JA., Fidock DA., Florent I., Fokou PV., Galstian A., Gamo FJ., Gokool S., Gold B., Golub T., Goldgof GM., Guha R., Guiguemde WA., Gural N., Guy RK., Hansen MA., Hanson KK., Hemphill A., Hooft Van Huijsduijnen R., Horii T., Horrocks P., Hughes TB., Huston C., Igarashi I., Ingram-Sieber K., Itoe MA., Jadhav A., Naranuntarat Jensen A., Jensen LT., Jiang RH., Kaiser A., Keiser J., Ketas T., Kicka S., Kim S., Kirk K., Kumar VP., Kyle DE., Lafuente MJ., Landfear S., Lee N., Lee S., Lehane AM., Li F, Little D., Liu L., Llinás M., Loza MI., Lubar A., Lucantoni L., Lucet I., Maes L., Mancama D., Mansour NR., March S., McGowan S., Medina Vera I., Meister S., Mercer L., Mestres J., Mfopa AN., Misra RN., Moon S., Moore JP., Morais Rodrigues Da Costa F., Müller J., Muriana A., Nakazawa Hewitt S., Nare B., Nathan C., Narraidoo N., Nawaratna S., Ojo KK., Ortiz D., Panic G., Papadatos G., Parapini S., Patra K, Pham N., Prats S., Plouffe DM., Poulsen SA., Pradhan A., Quevedo C., Quinn RJ., Rice CA., Abdo Rizk M., Ruecker A., St Onge R., Salgado Ferreira R., Samra J., Robinett NG., Schlecht U., Schmitt M., Silva Villela F., Silvestrini F., Sinden R., Smith DA., Soldati T., Spitzmüller A., Stamm SM., Sullivan DJ., Sullivan W., Suresh S., Suzuki BM., Suzuki Y., Swamidass SJ., Taramelli D., Tchokouaha LR., Theron A., Thomas D., Tonissen KF., Townson S., Tripathi AK., Trofimov V., Udenze KO., Ullah I., Vallieres C., Vigil E., Vinetz JM., Voong Vinh P., Vu H., Watanabe NA., Weatherby K., White PM., Wilks AF., Winzeler EA., Wojcik E., Wree M., Wu W., Yokoyama N., Zollo PH., Abla N., Blasco B., Burrows J., Laleu B., Leroy D., Spangenberg T., Wells T., Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 Jul 28;12(7):e1005763. DOI: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

Kaczor AA., Targowska-Duda KM., Budzynska B., Biala G., Silva AG., Castro M. In vitro, molecular modeling and behavioral studies of '3-{[4-(5-methoxy-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]methyl}-1,2-dihydroquinolin-2-one (D2AAK1) as a potential antipsychotic. Neurochem Int. 2016 Jun;96:84-99. DOI: 10.1016/j.neuint.2016.03.003. Epub 2016 Mar 8.

Digles D., Zdrazil B., Neefs JM., Van Vlijmen H., Herhaus C., Caracoti A., Brea J., Roibás B., Loza MI., Queralt Rosinach N., Furlong L., Gaulton A., Bartek L., Senger S., Chichester C., Engkvist O., Evelo C., Franklin NI., Marren D., Ecker G., Jacoby E. Open PHACTS Computational Protocols for in silico Target Validation of Cellular Phenotypic Screens: Knowing the Knowns Med. Chem. Commun. 2016 Jun 1;7(6):1237-1244. DOI: 10.1039/C6MD00065G. Epub 2016 May 11.

Kaczor AA., Silva AG., Loza MI., Kolb P., Castro M., Poso A. Structure-based virtual screening for dopamine D2 receptor ligands as potential antipsychotics. ChemMedChem. 2016 Apr 5;11(7):718-29. DOI: 10.1002/cmdc.201500599. Epub 2016 Mar 18.

Kucwaj-Brysz K., Warszycki D., Podlewska S., Witek J., Witek K., González Izquierdo A., Satala G., Loza MI., Lubelska A., Latacz G., Bojarski AJ., Castro M., Kiec-Kononowicz K., Handzlik J. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation. Eur J Med Chem. 2016 Apr 13;112:258-69. DOI: 10.1016/j.ejmech.2016.02.024. Epub 2016 Feb 9.

Bouzo-Lorenzo M., Santo-Zas I., Lodeiro M., Nogueiras R., Casanueva FF., Castro M., Pazos Y., Tobin AB., Butcher AJ., Camiña JP. Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins. Sci Rep. 2016 Mar 3;6:22495. DOI: 10.1038/srep22495.

Gamba I., Salvadó I., Brissos RF., Gamez P., Brea J., Loza MI., Vázquez ME., López MV. High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides Chem Commun (Camb). 2016 Jan 21;52(6):1234-7. DOI: 10.1039/c5cc07619f.

Anton-Torrecillas C., Loza MI., Brea J., González-Gómez JC. Concise asymmetric syntheses of novel phenanthroquinolizidines. Org Biomol Chem. 2016 Feb 21. DOI: 10.1039/C5OB02624E. Epub 2016 Jan 21.

Ruiz-Riquelme A., Sánchez-Iglesias S., Rábano A., Guillén-Navarro E., Domingo-Jiménez R., Ramos A., Rosa I., Senra A., Nilsson P., García Á., Araújo-Vilar D., Requena JR. Larger aggregates of mutant seipin in Celia's Encephalopathy, a new protein misfolding neurodegenerative disease. Neurobiol Dis. 2015 Nov;83:44-53. DOI: 10.1016/j.nbd.2015.08.006. Epub 2015 Aug 15.

Hoffmann C., Castro M., Rinken A., Leurs R., Hill SJ., Vischer HF. Ligand Residence Time at GPCRs - Why We Should Take Our Time to Study It. Mol Pharmacol. 2015 Sep. DOI: 10.1124/mol.115.099671. Epub 2015 Jul 7.

Vischer HF., Castro M., R Pin JF. G Protein-Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches. Mol Pharmacol mol. Sep 2015. 115.099440. DOI: 10.1124/mol.115.099440; published ahead of print July 2, 2015.

Varela Liste MJ.; Caltabiano G.; J Ward R.; Álvarez Curto E.; Marsango S.; Milligan G. The molecular basis of oligomeric organization of the human M3 muscarinic acetylcholine receptor. Mol Pharmacol. 2015 Jun;87(6):936-53. DOI: 10.1124/mol.114.096925. Epub 2015 Mar 13.

Marsango S., Caltabiano G., Pou C., Varela Liste MJ., Milligan G. Analysis of Human Dopamine D3 Receptor Quaternary Structure. Journal of Biological Chemistry. 290 - 24, pp. 15146 -15162. Jun 12 2015. DOI: 10.1074/jbc.M114.630681. Epub 2015 Apr 30.

Rodríguez A., Guerrero A., Gutiérrez de Terán H, Rodríguez D, Brea J, Loza MI, Rosell G, Bosh MP. New selective A2A agonists and A3 antagonists for human adenosine receptors: synthesis, biological activity and molecular docking studies. MedChemComm. May 2015; 6(6):1178-1185. DOI: 10.1039/C5MD00086F.

Ferreira da Costa J., García-Mera X., Caamaño O., Brea JM., Loza MI. Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity. Eur J Med Chem. 2015 Jun 15;98:212-220. DOI: 10.1016/j.ejmech.2015.05.029. Epub 2015 May 21.

Pau A., Catto M., Pinna G., Frau S., Murineddu G., Asproni B., Curzu MM., Pisani L., Leonetti F., Loza MI., Brea J. , Pinna GA., Carotti A. Multitarget-Directed Tricyclic Pyridazinones as G Protein-Coupled Receptor Ligands and Cholinesterase Inhibitors ChemMedChem. 2015 Jun;10(6):1054-70. DOI: 10.1002/cmdc.201500124. Epub 2015 Apr 29.

Campa VM., Capilla A., Varela Liste MJ., De La Rocha AM., Fernández-Troyano JC., Barreiro RB., López Giménez JF. Endocytosis as a biological response in receptor pharmacology: evaluation by fluorescence microscopy PLoS One. 2015 Apr 7;10(4):e0122604. DOI: 10.1371/journal.pone.0122604. eCollection 2015.

Tello JS., Myers JA., Macía MJ., Fuentes AF., Cayola L., Arellano G., Loza MI., Torrez V., Cornejo M., Miranda TB., Jørgensen PM. Elevational Gradients in ß-Diversity Reflect Variation in the Strength of Local Community Assembly Mechanisms across Spatial Scales. PLoS One. 2015 March 24;10(3):e0121458. DOI: 10.1371/journal.pone.0121458. Published online 2015 Mar 24.

Sabatini S., Manfroni G., Barreca ML., Bauer SM., Gargaro M., Cannalire R., Astolfi A., Brea J., Vacca C., Pirro M., Massari S., Tabarrini O., Loza MI., Fallarino F., Laufer SA., Cecchetti V. The pyrazolobenzothiazine core as a new chemotype of p38 alpha mitogen-activated protein kinase inhibitors. Chem Biol Drug Des. 2015 Oct. DOI: 10.1111/cbdd.12516. Epub 2015 Feb 19.

Marti-Solano M., Iglesias A., De Fabritiis G., Sanz F., Brea J., Loza MI., Pastor M., Selent J. Detection of New Biased Agonists for the Serotonin 5-HT2A Receptor: Modeling and Experimental Validation. Mol. Pharmacol. 2015 Apr;87(4):740-6. DOI: 10.1124/mol.114.097022. 10.1016/j.neuroscience. Epub 2015 Feb 6.

Vélez P., Izquierdo I., Rosa I., García, A. A 2D-DIGE-based proteomic analysis reveals differences in the platelet releasate composition when comparing thrombin and collagen stimulations. Sci. Rep. 2015 Feb 3;5:8198. DOI: 10.1038/srep08198

Varela MJ., Lage S., Caruncho HJ., Cadavid MI., Loza MI., Brea J. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: A comparative study. Neuroscience 2015. 2015 Apr 2. 28. 165-174. DOI: 10.1016/j.neuroscience.2015.01.031. Epub 2015 Jan 28.

Domínguez J., Fernández-Nieto F., Castro M., Catto M., Paleo MR., Porto S., Sardina FJ., Brea J., Carotti A., Villaverde MC., Sussman F. Computer Aided Structure Based Design of Multitarget Leads for Alzheimers Disease J Chem Inf Model. 2015 Jan 26;55(1):135-48. DOI: 10.1021/ci500555g. Epub 2014 Dec 24.

Anton-Torrecillas C., Bosque I., González-Gómez JC., Loza MI., Brea J. Syntheses and cytotoxicity of (R)- and (s)-7-methoxycryptopleurine. J. org. Chem. 2015 Jan 16;80(2):1284-90. DOI: 10.1021/jo502660r. Epub 2015 Jan 7.

Cristian R Munteanu, Humberto Gonzalez-Díaz, Rafael García, Mabel Loza, Alejandro Pazos. Bio-AIMS Collection of Chemoinformatics Web Tools Based on Molecular Graph Information and Artificial Intelligence Models. Comb Chem High Throughput Screen. 2015;18 (8), 735-50. DOI:10.2174/1386207318666150803140950.

Ratnam J., Zdrazil B., Digles D., Cuadrado-Rodriguez E., Neefs JM., Tipney H., Siebes R., Waagmeester A., Bradley G., Chau CH., Richter L., Brea J., Evelo CT., Jacoby E., Senger S., Loza MI., Ecker GF., Chichester C. The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research. PLoS One. PLoS One. 2014 Dec 18;9(12). 1-32. DOI: 10.1371/journal.pone.0115460. eCollection 2014.

Garcia AM., Brea JM., Morales JA., Perez DI., González A., Alonso-Gil S., Gracia-Rubio I., Ros-Simó C., Conde S., Cadavid MI., Loza MI., Pérez-Castillo A., Valverde O., Martínez A., Gil C. Modulation of cAMP specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. J Med Chem. 2014 Oct 23;57(20):8590-607. DOI: 10.1021/jm501090m. Epub 2014 Oct 8.

Rodríguez D., Brea J., Loza MI., Carlsson J. Structure-Based Discovery of Selective Serotonin 5-HT1B Receptor Ligands. Structure. 2014 Aug 15;22(8):1140-51. DOI: 10.1016/j.str.2014.05.017. Epub 2014 Jul 17.

Vélez P., Parguiña AF., Ocaranza R., Grigorian L., Rosa I., Alonso-Orgaz S., De La Cuesta F., Guitián E., Moreu J., Barderas MG., González-Juanatey JR., García A. Identification of a circulating microvesicle protein network involved in ST-elevation myocardial infarction. Thromb Haemost. 2014 Oct;112(4):716-26. DOI: 10.1160/TH14-04-0337. Epub 2014 Jul 10.

Ramos A., Rodríguez-Seoane C., Rosa I., Trossbach SV., Ortega-Alonso A., Tomppo L., Ekelund J., Veijola J., Järvelin MR., Alonso J., Veiga S., Sawa A., Hennah W., García A., Korth C., Requena JR. Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Hum Mol Genet. 2014 Nov 15;23(22):5859-65. DOI: 10.1093/hmg/ddu303. Epub 2014 Jun 16.

Kaczor AA., Makarska-Bialokoz M., Selent J., De La Fuente RA., Marti-Solano M., Castro M. Application of BRET for Studying G Protein-Coupled Receptors. Mini-Rev Med Chem. 2014 May;14(5):411-25. DOI: 10.2174/1389557514666140428113708

Bosque I., González-Gómez JC., Loza MI., Brea J. Natural Tetraponerines: A General Synthesis and Antiproliferative Activity. J Org Chem. 2014 May 2;79 (9):3982–3991. DOI: 10.1021/jo500446f. Epub 2014 Apr 14.

Selent J., Marti-Solano M., Rodríguez J., Atanes P., Brea J., Castro M., Sanz F., Loza MI., Pastor M. Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles. Eur J Med Chem. 2014 Apr 22;77:91-5. DOI: 10.1016/j.ejmech.2014.02.058. Epub 2014 Feb 28.

Galmozzi A., Domínguez E., Godio C., Saez E. Application of Activity-Based Protein Profiling to Study Enzyme Function in Adipocytes. Methods Enzymology. 12 February 2014;538:151-69. DOI: 10.1016/B978-0-12-800280-3.00009-8.

Domínguez E., Galmozzi A., Chang JW., Hsu KL., Pawlak J., Li W., Godio C., Thomas J., Partida D., Niessen S., O'Brien PE., Russell AP., Watt MJ., Nomura DK., Cravatt BF., Saez E. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nature Chemical Biology. 2014 Feb;10(2):113-21. DOI: 10.1038/nchembio. Epub 2013 Dec 22.

Carro L., Torrado M., Raviña E., Masaguer CF., Lage S., Brea J., Loza MI. Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols asdual dopamine/serotonin ligands. Eur J Med Chem. Jan 7 2014;71:237-49. DOI: 10.1016/j.ejmech.2013.10.066. Epub 2013 Nov 20.

Atanes P., Lacivita , Rodríguez J., Brea J., Burgueño J., Vela JM., Cadavid MI., Loza MI., Leopoldo M., Castro M. The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (LP-211) and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide (MEL-9) exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding. Pharmacology Research & Perspectives. 2013. DOI: 10.1002/prp2.13. Epub 2013 Dec 5.

Crespo A., El Maatougui A., Biagini P., Azuaje J., Coelho A., Brea J., Loza MI., Cadavid MI., García-Mera X., Gutiérrez De Terán H., Sotelo E. Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Pontent and Selective A(2B) Adenosine Receptor Antagonists. ASC Med Chem Lett. 2013 Nov 14;4(11): 1031-1036. DOI: 10.1021/ml400185v. eCollection 2013 Nov 14.

Redondo M., Soteras I., Brea J., González-García A., Cadavid MI., Loza MI., Martínez A., Gil C., Campillo NE. Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities. Eur J Med Chem. 2013;70:781-8. DOI: 10.1016/j.ejmech.2013.10.035. Epub 2013 Oct 22.

Ferreira da Costa J., Caamaño O., Fernández F., García-Mera X., Sampaio-Días IE., Brea JM., Cadavid MI. Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of L-prolyl-L-leucyl-glycinamide (PLG) modified in the L-proline or L-pr oline and L-leucine scaffolds. Eur J Med Chem. 2013 Nov;69:146-58. DOI: 10.1016/j.ejmech.2013.08.001. Epub 2013 Aug 22.

Insua I., Alvarado M., Masaguer CF., Iglesias A., Brea J., Loza MI., Carro L. Synthesis and binding affinity of new 1,4-disubstituted triazoles as potential dopamine D(3) receptor ligands. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5586-91. DOI: 10.1016/j.bmcl.2013.08.047. Epub 2013 Aug 16

Cambón A., Brea J., Loza MI., Álvarez-Lorenzo C., Concheiro A., Barbosa S., Taboada P., Mosquera V. Cytocompatibility and P-glycoprotein inhibition of block copolymers: structure-activity relationship. Mol Pharm. 2013 Aug 5;10(8):3232-41. DOI: 10.1021/mp4002848. Epub 2013 Jun 25.

Azzaoui K., Jacoby E., Senger S., Rodríguez EC., Loza M., Zdrazil B., Pinto M., Williams AJ., De La Torre V., Mestres J., Pastor M., Taboureau O., Rarey M., Chichester C., Pettifer S., Blomberg N., Harland L., Williams-Jones B., Ecker GF. Scientific competency questions as the basis for semantically enriched open pharmacological space development. Drug Discov Today. 2013 Sep;18(17-18):843-52. DOI: 10.1016/j.drudis.2013.05.008. Epub 2013 May 20.

Lozano MV., Lollo G., Alonso-Nocelo M., Brea J., Vidal A., Torres D., Alonso MJ. Polyarginine nanocapsules: a new platform for intracellular drug delivery. Journal of Nanoparticle Research. Journal of Nanoparticle Research. 2013 Feb 27; 15:1515. DOI: 10.1007/s11051-013-1515-7. Epub 27 February 2013.

Cambón A., Rey-Rico A., Mistry D., Brea J., Loza MI., Attwood D., Barbosa S., Álvarez-Lorenzo C., Concheiro A., Taboada P., Mosquera V. Doxorubicin-loaded micelles of reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) block copolymers as efficient "active" chemotherapeutic agents. Int J Pharm. 2013 Mar 10;445(1-2):47-57. DOI: 10.1016/j.ijpharm.2013.01.056. Epub 2013 Feb 1.

De las Casas-Engel M., Domínguez-Soto A., Sierra-Filardi E., Bragado R., Nieto C., Puig-Kroger A., Samaniego R., Loza M., Corcuera MT., Gómez-Aguado F., Bustos M., Sánchez-Mateos P., Corbí AL. Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7. J Immunol. 2013 Mar 1;190(5):2301-10. DOI: 10.4049/jimmunol.1201133. Epub 2013 Jan 25.

Cambón A., Rey-Rico A., Barbosa S., Soltero JF., Yeates SG., Brea J., Loza MI., Álvarez-Lorenzo C., Concheiro A., Taboada P., Mosquera V. Poly(styrene oxide)-poly(ethylene oxide) block copolymers: From "classical" chemotherapeutic nanocarriers to active cell-response inducers. J Control Release. 2013 Apr 10;167(1):68-75. DOI: 10.1016/j.jconrel.2013.01.010. Epub 2013 Jan 23.

Yaziji V., Rodríguez D., Coelho A., García-Mera X., El Maatougui A., Brea J., Loza MI., Gutiérrez-de-Terán H., Sotelo E. Selective and potent adenosine A (3) receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl) acetamide scaffold. Eur J Med Chem. 2013 Jan;59:235-42.z/ DOI: 10.1016/j.ejmech.2012.11.010. Epub 2012 Nov 24.

Lozano MV., Esteban H., Brea J., Loza MI., Torres D., Alonso MJ. Intracellular delivery of docetaxel using freeze-dried polysaccharide nanocapsules. J Microencapsul. 2013;30(2):181-8. DOI: 10.3109/02652048.2012.714411. Epub 2012 Oct 22.

Parguiña AF., Alonso J., Rosa I., Vélez P., González-López MJ., Guitián E., Ebble JA., Loza MI., García A. A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation. Blood. 2012 Dec 20;120(26):e117-26. DOI: 10.1182/blood-2012-09-456004. Epub 2012 Oct 10.

Redondo M., Palomo V., Brea J., Pérez DI., Martín-álvarez R., Pérez C., Paúl-Fernández N., Conde S., Cadavid MI., Loza MI., Mengod G., Martínez A., Gil C., Campillo NE. Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice. ACS Chem Neurosci. 2012 Oct 17;3(10):793-803. DOI: 10.1021/cn300105c. Epub 2012 Aug 8.

Areias F., Costa M., Castro M., Brea J., Gregori-Puigjané E., Proença MF., Mestres J., Loza MI. New chromene scaffolds for adenosine A(2A) receptors: Synthesis, pharmacology and structure-activity relationships. Eur J Med Chem. 2012 Aug;54:303-10. DOI: 10.1016/j.ejmech.2012.05.009. Epub 2012 May 14.

Redondo M., Brea J., Perez DI., Soteras I., Val C., Pérez C., Morales-García JA., Alonso-Gil S., Paul-Fernández N., Martín-Álvarez R., Cadavid MI, Loza MI, Pérez-Castillo A., Mengod G., Campillo NE., Martínez A., Gil C. Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds. J Med Chem. 2012 Apr 12;55(7):3274-84. DOI: 10.1021/jm201720d. Epub 2012 Mar 16.

Shai E., Rosa I., Parguiña AF., Motahedeh S., Varon D., García A. Comparative analysis of platelet-derived microparticles reveals differences in their amount and proteome depending on the platelet stimulus. J Proteomics. 2012 Dec 5. 5;76 Spec No.:287-96. DOI: 10.1016/j.jprot.2012.02.030. Epub 2012 Mar 5.

Oyarzun-Ampuero FA., Brea J., Loza MI., Alonso MJ., Torres D. A potential nanomedicine consisting of heparin-loaded polysaccharide nanocarriers for the treatment of asthma. Macromol Biosci. Feb 2012;12(2):176-83. DOI: 10.1002/mabi.201100102. Epub 2011 Nov 23.

Colas E., Muinelo L., Llaurado M., Monge M., Barbazan J., González M., Schoumacher M., Alonso L., Pedrola N., Ertekin T., Ruiz A., Castellvi J., Doll A., Gil-Moreno A., Vazquez-Levin M., Lapyckyj L., López-López R., Robine S., Friederich E., Castro M., Reventos J., Vignjevic D., Abal M. ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas. Oncogene. 2012 Nov 8;31(45):4778-88. DOI: 10.1038/onc.2011.632. Epub 2012 Jan 23.

Redondo M., Zarruk JG., Ceballos P., Pérez DI., Pérez C., Pérez-Castillo A., Moro MA., Brea J., Val C., Cadavid MI., Loza MI., Campillo NE., Martínez A., Gil C. Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Eur J Med Chem. Jan 2012;47(1):175-85. DOI: 10.1016/j.ejmech.2011.10.040. Epub 2011 Nov 4.

Senis Y., García A. Platelet proteomics: state of the art and future perspective. Methods Mol Biol. 2012;788:367-99. DOI: 10.1007/978-1-61779-307-3_24

Barcelo M., Raviña E., Varela MJ., Brea J., Loza MI., Massager CF. Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands. Med. Chem. Commun. 2011; 2(12):1194-1200. DOI: 10.1039/C1MD00202C. Epub 11th October 2011

Parguiña AF., Grigorian-Shamagian L., Agra RM., López-Otero D., Rosa I., Alonso J., Teijeira-Fernández E., González-Juanatey JR., García A. Variations in Platelet Proteins Associated With ST-Elevation Myocardial Infarction: Novel Clues on Pathways Underlying Platelet Activation in Acute Coronary Syndromes. Arterioscler Thromb Vasc Biol. 2011 Dec;31:2957-2964. DOI: 10.1161/ATVBAHA.111.235713. Epub 2011 Sep 15.

Varela MJ., Brea J., Loza MI., Maldonado R., Robledo P. Sensitization to MDMA locomotor effects and changes in the functionality of 5-HT2A and D2 receptors in mice. Behavioural Pharmacology. Aug 22 2011;Volume 22, Issue 4, p 362–369. DOI: 10.1097/FBP.0b013e3283487346

García A., Eiras S., Parguiña AF., Alonso J., Rosa I., Salgado-Somoza A., Rico TY., Teijeira-Fernández E., González-Juanatey JR. High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation. Int J Cardiol. 2011 Aug 4;150(3):283-90. DOI: 10.1016/j.ijcard.2010.04.036. Epub 2010 May 6.

Costa M., Areias F., Castro M., Brea J., Loza MI., Proença F. Synthesis of novel chromene scaffolds for adenosine receptors. Org Biomol Chem. 2011 Jun 7;9(11):4242-9. DOI: 10.1039/c1ob05305a. Epub 2011 Apr 20.

Sussman F., Otero JM., Villaverde MC., Castro M., Domínguez JL., González-Louro L., Estévez RJ., Estévez JC. On a possible neutral charge state for the catalytic dyad in ß-secretase when bound to hydroxyethylene transition state analogue inhibitors. J Med Chem. 2011 Apr 28;54(8):3081-5. DOI: 10.1021/jm101568y. Epub 2011 Mar 31.

Eastwood P., Esteve C., Gonzalez J., Fonquerna S., Aiguade J., Carranco I., Domenech T., Aparici M., Miralpeix M., Albertí J., Cordoba M., Fernández R., Pont M., Godessart N., Prats N., Loza MI., Cadavid MI., Nueda A., Vidal B. Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Medicinal Chemistry Letters. 2011;2(3):213-218. DOI: 10.1021/ml100249e. eCollection 2011 Mar 10.

Yaziji V., Rodríguez D., Gutiérrez deTerán H., Coelho A., Caamaño O., García-Mera X., Brea J., Loza MI., Cadavid MI., Sotelo E. Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. Jan 27 2011;54(2):457-71. DOI: 10.1021/jm100843z. Epub 2010 Dec 27.

Jenkins L., Brea J., Smith NJ., Hudson BD., Reilly G., Bryant NJ., Castro M., Loza MI., Milligan G. Identification of novel, species selective agonists of the G protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα 13. Biochem J. 2010 Dec 15; 432:51–459. DOI: 10.1042/BJ20101287.

Álvarez-Lorenzo C., Rey-Rico A., Brea J., Loza MI., Concheiro A., Sosnik A. Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: branched versus linear derivatives. Nanomedicine (Lond). Nov 2010;5(9):1371-83. DOI: 10.2217/nnm.10.53.

Giovannoni MP., Vergelli C., Cilibrizzi A., Crocetti L., Biancalani C., Graziano A., Piaz VD., Loza MI., Cadavid MI., Díaz JL., Gavaldá A. Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands. Bioorganic & Medicinal Chemistry 2010 Nov 15;18(22):7890-9. DOI: 10.1016/j.bmc.2010.09.043. Epub 2010 Sep 22.

Parguiña AF., Grigorian-Shamajian L., Agra RM., Teijeira-Fernández E., Rosa I., Alonso J, Viñuela-Roldán JE., Seoane A., González-Juanatey JR., García A. Proteins involved in platelet signaling are differentially regulated in Acute Coronary S índrome: a proteomic study. PLoS ONE. 2010 Oct 14;5(10):e13404. DOI: 10.1371/journal.pone.0013404

López L., Selent J., Ortega R., Masaguer CF., Domínguez E., Areias F., Brea J., Loza MI., Sanz F., Pastor M. Synthesis, 3D-QSAR, and Structural Modeling of Benzolactam Derivatives with Binding Affinity for the D2 and D3 Receptors. ChemMedChem. Aug 2 2010;5(8):1300-17. DOI: 10.1002/cmdc.201000101.

Varin T., Gutiérrez-de-Terán H., Castro M., Brea J., Fabis F., Dauphin F., Aqvist J., Lepailleur A., Pérez P., Burgueño J., Vela JM., Loza MI., Rodrigo J. Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists. Br J Pharmacol. 2010 Mar;159(5):1069-81. DOI: 10.1111/j.1476-5381.2009.00481.x. Epub 2009 Nov 18.

García A. Clinical proteomics in platelet research: challenges ahead. J Thromb Haemost. 2010 Aug ;8(8):1784-5. DOI: 10.1111/j.1538-7836.2010.03949.x.

Trifirò G., Gambassi G., Sen EF., Caputi AP., Bagnardi V., Brea J., Sturkenboom MC. Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study. Ann Intern Med. 2010 Apr 6;152(7):418-25. DOI: 10.7326/0003-4819-152-7-201004060-00006

González-Juanatey JR., Parguiña AF., Rosa I., Grigorian-Shamagián L., Teijeira-Fernández E., Alonso J., Agra R., García A. Proteomic analysis of circulating human platelets reveals potential biomarkers in non-ST segment elevation acute coronary syndrome. J Am Coll Cardiol. 2010 Mar;55:A112.E1047. DOI: 10.1016/S0735-1097(10)61048-0.

Areias FM., Brea J., Gregori-Puigjané E., Zaki ME., Carvalho MA., Domínguez E., Gutiérrez-de-Terán H., Proença MF., Loza MI., Mestres J. In silico directed chemical probing of the adenosine receptor family. Bioorg Med Chem. 2010 May 1;18(9):3043-52. DOI: 10.1016/j.bmc.2010.03.048. Epub 2010 Mar 27.

Hierrezuelo J., López-Romero JM., Rico R., Brea J., Loza MI., Cai C-, Algarra M. Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. Bioorg Med Chem. 2010 Mar;18(6):2081-8. DOI: 10.1016/j.bmc.2010.02.014. Epub 2010 Feb 15.

Selent J., Bauer-Mehren A., López L., Loza MI., Sanz F., Pastor M. A novel multilevel statistical method for the study of the relationships between multireceptorial binding affinity profiles and in vivo endpoints. Mol Pharmacol. 2010 Feb; 77(2):149-58. DOI: 10.1124/mol.109.060103. Epub 2009 Nov 10.

Rodríguez-Borges JE., García-Mera X., Balo MC., Brea J., Caamaño O., Fernández F., López C., Loza MI., Nieto MI. Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists. Bioorg Med Chem. 2010 Mar 1;18(5):2001-9. DOI: 10.1016/j.bmc.2010.01.028. Epub 2010 Jan 15.

Nieto MI., Balo MC., Brea J., Caamaño O., Fernández F., García-Mera X., López C., Loza MI., Rodríguez-Borges JE., Vidal B. Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists. Eur J Med Chem. 2010 Jul;45(7):2884-92. DOI: 10.1016/j.ejmech.2010.03.011. Epub 2010 Jan 15.

Brea J., Castro-Palomino J., Yeste S., Cubero E., Párraga A., Domínguez E., Loza MI. Emerging opportunities and concerns for drug discovery at serotonin 5-HT2B receptors. Curr Top Med Chem. 2010;10(5):493-503. DOI: 10.2174/156802610791111524. In Press.

Zardaín E., Del Valle MO., Loza MI., García E., Lana A., Markham WA., López ML. Psychosocial and behavioural determinants of the implementation of Pharmaceutical Care in Spain. Pharm World Sci. 2009 Apr;31(2):174-82. DOI: 10.1007/s11096-008-9275-7. Epub 2008 Dec 13.

Carro L., Raviña E., Domínguez E., Brea J., Loza MI., Masaguer C. Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6059-6062. DOI: 10.1016/j.bmcl.2009.09.041. Epub 2009 Sep 17.

Ferrandon S., Feinstein TN., Castro M., Wang B., Bouley R., Potts JT., Gardella TJ., Vilardaga JP. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol. 2009 Oct;5(10):734-42. DOI: 10.1038/nchembio.206. Epub 2009 Aug 23.

Senis YA., Antrobus R., Severin S., Parguiña AF., Rosa I., Zitzmann N., Watson SP., García A. Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. Journal of Thrombosis and Haemostasis. 2009 Oct;7:1718-1726. DOI: 10.1111/j.1538-7836.2009.03565.x. Epub 2009 Aug 11.

Gutierrez-de-Teran H., Correia C., Rodríguez D., Carvalho MA., Brea J., Cadavid MI., Loza MI., Proenca MF., Areias F. Identification of Novel Scaffolds from an Original Chemical Library as Potential Antipsychotics. QSAR Comb. Sci. 2009;28(8): 856 – 860. DOI: 10.1002/qsar.200860198. Epub 10 August 2009

Balo MC., Brea J., Caamaño O., Fernández F., García-Mera X., López C., Loza MI., Nieto MI., Rodríguez-Borges JE. Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfurylxanthines as adenosine receptor antagonists. Bioorg Med Chem. 2009 Sep 15;17(18):6755-60. DOI: 10.1016/j.bmc.2009.07.034. Epub 2009 Jul 23.

Yaziji V., Coelho A., El Maatougui A., Brea J., Loza MI., García-Mera X., Sotelo E. Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists. J. Comb. Chem. Jul-Aug 2009;11: 519–522. DOI: 10.1021/cc900044k.

Oyarzun-Ampuero FA., Brea J., Loza MI., Torres D., Alonso MJ. Chitosan-hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma. Int J Pharm. 2009 Nov 3;381(2):122-9. DOI: 10.1016/j.ijpharm.2009.04.009. Epub 2009 Apr 15.

Fernández F., Caamaño O., Nieto MI., López C., García-Mera X., Stefanachi A., Nicolotti O., Loza MI., Brea J., Esteve C., Segarra V., Vidal B., Carotti A. 1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potente adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships. Bioorg Med Chem. 2009 May 15; 15;17(10):3618-29. DOI: 10.1016/j.bmc.2009.03.062. Epub 2009 Apr 5.

Zhubi A., Veldic M., Puri NV., Kadriu B., Caruncho H., Loza MI., Sershen H., Lajtha A., Smith R., Guidotti A., Davis J., Costa E. An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes. Schizophrenia Resarch. 2009 Jun;111(1-3):115-22. DOI: 10.1016/j.schres.2009.03.020. Epub 2009 Apr 5.

Nieto MI., Balo MC., Brea J., Caamaño O., Cadavid MI., Fernández F., Mera XG., López C., Rodríguez-Borges JE. Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists. Bioorg Med Chem. 2009 May 1;17(9):3426-32. DOI: 10.1016/j.bmc.2009.03.029. Epub 2009 Mar 21. Epub 2009 Mar 21.

Brea J., Castro M., Giraldo J., López-Gimenez JF., Padin JF., Quintian F., Cadavid MI., Vilaro T., Mengod G., Berg KA., Clarke WP., Vilardaga JP, Milligan G, Loza MI. Evidence for distinct antagonist-revealed functional states of 5-HT2A receptor homodimers. Mol Pharmacol. 2009 Jun;75(6):1380-91. DOI: 10.1124/mol.108.054395. Epub 2009 Mar 11.

Ortega R., Raviña E., Masaguer CF., Areias F., Brea J., Loza MI., López L., Selent J., Pastor M., Sanz F. Synthesis, Binding Affinity and SAR of New Benzolactam Derivatives as Dopamine D3 Receptor Ligands. Bioorg Med Chem Lett. 2009 Mar 15;15;19(6):1773-8. DOI: 10.1016/j.bmcl.2009.01.067. Epub 2009 Jan 27.

Narayan R., Gangadharan B., Hantz O., Antrobus R., García A., Dwek RA., Zitzmann N. Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection. J Proteome Res. 2009 Jan 8;8:118-122. DOI: 10.1021/pr800562j.

Laguna R., Cadavid MI., Castro M., Brea JM., Loza MI. La experiencia de 10 años de docencia de la asignatura "Fuentes de Información Farmacológica de Medicamentos" impartida con el método de enseñanza basado en la resolución de problemas. Revista d'educació superior en Farmacia. 2009; nº 4.

Coelho A., Crespo A., Biagini P., Sotelo E. Synthetic application of polystyrene-supported 1,1,3,3-tetramethylguanidine. Comb Chem High Throughput Screen. 2008 Dec;11(10):843-7. DOI: 10.2174/138620708786734253.

Meyers C., Yáñez M., Elmaatougi A., Verhelst T., Coelho A., Fraiz N., Lemiere GL., Garcia-Mera X., Laguna R., Cano E., Maes Bert UW., Sotelo E. 2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: Design, synthesis, and SAR studies. Bioorganic & Medicinal Chemistry Letters. 2008 Jan 15;18(2):793-7. DOI: 10.2174/138620708786734253. Epub 2007 Nov 17.

Stefanachi A., Nicolotti O., Leonetti F., Cellamare S., Campagna F., Loza MI., Brea JM., Mazza F., Gavuzzo E., Carotti A. 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A(2B) adenosine receptor antagonists: Design, synthesis, structure-affinity and structure-selectivity relationships. Bioorg Med Chem. 2008 Nov 15;16(22):9780-9. DOI: 10.1016/j.bmc.2008.09.067. Epub 2008 Sep 30.

Aranda R., Villalba K., Raviña E., Masaguer CF., Brea J., Areias F., Domínguez E., Selent J., López L., Sanz F., Pastor M., Loza MI. Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics. Journal of Medicinal Chemistry. 2008 Oct 9;51(19):6085-94. DOI: 10.1021/jm800602w. Epub 2008 Sep 11.

Buceta M., Domínguez E., Castro MA., Brea JM., Álvarez D., Barcala J., Valdés L., Álvarez-Calderón P., Domínguez F., Vidal B., Díaz JL, Miralpeix M., Beleta J., Cadavid MI., Loza MI. A new Chemicals tool (C0036E08) supports the role of adenosine A2B receptors in mediating human mast cell activation. Biochemical Pharmacology. 2008 Oct 1;76(7):912-21. DOI: 10.1016/j.bcp.2008.07.011. Epub 2008 Jul 19.

Rodriguez-Borges JE., Gonclalves S., Do Vale M., García-Mera X., Coelho A., Sotelo, E. Click Chemistry Approach to Assembly Proline Mimetic Libraries Containing 1,4-Substituted 1,2,3-Triazoles. Journal of Combinatorial Chemistry. 2008 May-June;10(3):372-375. DOI: 10.1021/cc800035z. Epub 2008 Apr 30

Hughes JR., Meireles AM., Fisher KH., García A. A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 2008 Apr 22;6(4):e98. DOI: 10.1371/journal.pbio.0060098.

Martínez A., Gutiérrez-de-Terán H., Brea J., Raviña E., Loza MI., Cadavid MI., Sanz F., Vidal B., Segarra V., Sotelo E. Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines. Bioorg Med Chem. 2008 Feb 15;16(4):2103-13. DOI: 10.1016/j.bmc.2007.10.103. Epub 2008 Jan 24

Rico-Gómez R., López-Romero JM., Hierrezuelo J., Brea J., Loza MI., Pérez-González M. Synthesis of new mannosyl, galactosyl and glucosyl theophylline nucleosides with potential activity as antagonists of adenosine receptors. DEMA-induced cyclization of glycosylideneiminouracils. Carbohydr Res. 2008 Apr 7;343:855-864. DOI: 10.1016/j.carres.2008.01.011. Epub 2008 Jan 18.

Stefanachi A., Brea JM., Cadavid MI., Centeno NB., Esteve C., Loza MI., Martinez A., Nieto R., Raviña E., Sanz F., Segarra V., Sotelo E., Vidal B., Carotti A. 1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A(2B) adenosine receptor. Bioorg Med Chem. 2008 Mar 15;16(6):2852-69. DOI: 10.1016/j.bmc.2008.01.002. Epub 2008 Jan 10.

Meyers C., Rombouts G., Loones Kristof TJ., Coelho, A., Maes Bert UW. Auto-tandem catalysis: synthesis of substituted 11H-indolo[3,2-c]quinolines via palladium-catalyzed intermolecular C-N and intramolecular C-C bond formation. Advanced Synthesis Catalysis. 2008;350(3),465-470. DOI: 10.1002/adsc.200700328. Epub 11 Feb 2008.

Coelho A., Raviña E., Fraiz N., Yañez M., Laguna R., Cano E., Sotelo E. Design, Synthesis, and Structure-Activity Relationships of a Novel Series of 5-Alkylidenepyridazin-3(2H)-ones with a Non-cAMP-Based Antiplatelet Activity. Journal of Medicinal Chemistry. 2007 Dec, 50(26), 6476-6484. DOI: 10.1021/jm061401d. Epub 2007 Nov 22.

Dezi C., Brea J., Alvarado M., Raviña E., Masaguer C., Loza MI., Sanz F., Pastor M. Multi-structure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of the 5-HT2A receptor. Journal of Medicinal Chemistry. 2007 Jul 12;12;50(14):3242-55. DOI: 10.1021/jm070277a. Epub 2007 Jun 19.

Barceló M., Raviña E., Masaguer C., Dominguez E., Areias F., Brea JM., Loza MI. Synthesis and Binding Affinity of New Pyrazole and Isoxazole Derivatives as Potential Atypical Antipsychotics. Bioorg Med Chem Lett. 2007 Sep 1;1;17(17):4873-7. DOI: 10.1016/j.bmcl.2007.06.045 Epub 2007 Jun 14.

Pardo M., García A., Antrobus R., Blanco MJ., Dwek RA., Zitzmann N. Biomarker discovery from uveal melanoma secretomes: identification of gp100 and Cathepsin D in patient serum. Journal of Proteome Research. 2007 Jul;6:2802-2811. DOI: 0.1021/pr070021t. Epub 2007 Jun 1.

Vidal B., Nueda A., Esteve C., Domenech T., Benito S., Reinoso RF., Pont M., Calbet M., López R., Cadavid MI., Loza MI., Cardenas A., Godessart N., Beleta J., Warrellow G., Ryder H. Discovery and Characterization of 4'-(2-Furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a Potent, Selective, and Efficacious A2B Adenosine Receptor Antagonist. Journal of Medicinal Chemistry. 2007 May 31;31;50(11):2732-6. DOI: 10.1021/jm061333v. Epub 2007 May 1.

Senis YA., Tomlinson MG., García A., Dumon S., Heath VL., Herbert J., Cobbold SP., Spalton JC., Ayman S., Zitzmann N., Bicknell R., Frampton J., Authi K., Martin A., Wakelam MJO., Watson SP. A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein. Molecular & Cellular Proteomics. 2007 Mar;6:548-564. DOI: 10.1074/mcp.D600007-MCP200. Epub 2006 Dec 23.

Coelho A., El-Maatougui A., Raviña E., Cavaleiro, JA., Silva AM. Efficient consecutive alkylation-knoevenagel functionalizations in formyl aza-heterocycles using supported organic bases. Synlett. Apr 2007;(19), 3324-3328. DOI: 10.1002/chin.200716139

Balo C., Lopez C., Brea JM., Fernández F., Caamaño O. Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4]Triazolo[1,5-c]quinazolines. Chem Pharm Bull (Tokyo). 2007 Mar;55(3):372-5. DOI: 10.1248/cpb.55.372.

Domínguez E., Loza MI., Padín F., Gesteira A., Paz E., Páramo M., Brenlla J., Pumar E., Iglesias F., Cibeira A., Castro M., Caruncho H., Carracedo A., Costas J. Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population. Schizophrenia Research. 2007 Feb;90(1-3):123-9. DOI: 10.1016/j.schres.2006.09.022. Epub 2006 Nov 27.

García A., Senis YA., Antrobus R., Hughes CE., Dwek RA., Watson SP., Zitzmann N. A global proteomics approach identifies novel phosphorylated signalling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics. 2006;6:5332-5343. DOI: 10.1002/pmic.200600299. Epub 02 October 2006.

Padín JF., Rodríguez MA., Domínguez E., Dopeso-Reyes IG.; Buceta M.; Cano E.; Sotelo E., Brea J., Caruncho HJ.; Cadavid MI., Castro MA., Loza MI. Parallel regulation by olanzapine of the patterns of expression of 5-ht2a and d3 receptors in rat central nervous system and blood cells. Neuropharmacology. 2006 Sep;51(4):923-32. DOI: 10.1016/j.neuropharm.2006.06.005. Epub 2006 Aug 14.

Pardo M., García A. , Thomas B., Piñeiro A., Akoulitchev A., Dwek RA., Zitzmann N. The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and led to the identification of DJ-1 as a potential serum biomarker. International Journal of Cancer. 2006;119:1014-1022. DOI: 10.1002/ijc.21942. Epub 05 June 2006.

Brea J., Castro M., Loza MI., Masaguer CF., Raviña E., Dezi C., Pastor M., Sanz F., Cabrero-Castel A., Galan-Rodriguez B., Fernandez-Espejo E., Maldonado R., Robledo P. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine. Neuropharmacology. 2006;51(2):251-62. DOI: 10.1016/j.neuropharm.2006.03.021. Epub 2006 May 11.

Esteve C., Nueda A., Diaz JL., Beleta J., Cardenas A., Lozoya E., Cadavid MI., Loza MI., Ryder H., Vidal B. New pyrrolopyrimidin-6-yl benzenesulfonamides: Potent A(2B) adenosine receptor antagonists. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3642-5. DOI: 10.1016/j.bmcl.2006.04.074. Epub 2006 May 11.

Coelho A., Sotelo E. Straightforward Entry to Libraries of Diversely Substituted Azinones by a Consecutive Aza-Michael/Palladium-Catalyzed Functionalization Strategy. Journal of Combinatorial Chemistry. 2006 May;8(3), 388-400. DOI: 10.1021/cc060007y.

Senis YA., Kim PY., Fuller GLJ., García A. , Prabhakar S., Brittan H., Zitzmann N., Warrell DA., Kamiguti AS., Theakston RDG., Nesheim ME., Laing G. Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara. Biochimica et Biophysica Acta. 2006 May;1764:863-871. DOI: 10.1016/j.bbapap.2006.03.004. Epub 2006 Apr 7.

Crespo A., Meyers C., Coelho A., Yáñez M., Fraiz N., Sotelo E., Maes BU., Laguna R., Cano E., Lemiere GL., Raviña, E. Pyridazines part 41: Synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones. Bioorg. Med. Chem. Lett. 2006 Feb;16(4), 1080-1083. DOI: 10.1016/j.bmcl.2005.10.073. Epub 2005 Nov 14.

García A. Proteome analysis of signalling cascades in human platelets. Blood Cells. Molecules Diseases. 2006;36:152-156. DOI: 10.1016/j.bcmd.2005.12.013. Epub 2006 Feb 17.

Coelho A., Sotelo E. Straightforward three-component palladium-catalysed synthesis of pyridazin-3(2H)-one libraries. Combinatorial Chemistry & High Throughput Screening. 2006 Jan;9(1), 15-19. DOI: 10.2174/138620706775213868.

Suzuki-Inoue K., Fuller GLJ., García A., Eble JA., Pohlmann S., Inoue O., Gartner TK., Hughan SC., Pearce AC., Schweighoffer E., Zitzmann N., Morita T., Tybulewicz VLJ., Ozaki Y., Watson SP. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood. 2006 Jun 15;107, 542-549. DOI: dx.doi.org/10.1182/blood-2005-05-1994. Epub 2005 Sep 20.

Carotti A., Cadavid MI., Centeno NB., Esteve C., Loza MI., Martínez A., Nieto R., Raviña E., Sanz E., Segarra V., Sotelo E., Stefanachi A., Vidal B. Design, synthesis and structure-activity relationships at human A2B adenosine receptor of 1-,3-,8-and 9-substituted-9-deazaxanthines. Journal of MedIcinal Chemestry. 2006 Jan;12;49(1):282-99. DOI: 10.1021/jm0506221.

Caruncho HJ., Loza MI. Tendiendo puentes entre la psiquiatria y las neurociencias. Rev. Gal. Psiq. Neuroc. 2006;5:7-8. In Press.

Simmons A., Gangadharan B., Hodges A., Sharrocks K., Prabhakar S., García A., Dwek R., Zitzmann N., McMichael A. Nef mediated lipid raft exclusion of UbcH7 positively regulates T cell signaling. Immunity. 2005 Dec;23,621-634. DOI: 10.1016/j.immuni.2005.11.003

Pardo M., García A., Thomas B., Piñeiro A., Akoulitchev A., Dwek RA., Zitzmann N. Proteome analysis of a human uveal melanoma primary cell culture by two-dimensional gel electrophoresis and mass spectrometry. Proteomics. 2005 Dec;5(18), 4980-4993. DOI: 10.1002/pmic.200500030.

García A., Watson SP., Dwek RA., Zitzmann N. Applying proteomics technology to platelet research. Mass Spectrom Rev. 2005 Nov-Dec;24, 918-930. DOI: 10.1002/mas.20047.

Castro M., Nikolaev VO., Palm D., Lohse MJ., Vilardaga JP. Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci USA. 2005;102(44):16084-9. DOI: 10.1073/pnas.0503942102. Epub 2005 Oct 18.

Coelho A., Sotelo E. Expanding the Chemical Diversity of Azinone Libraries by A Consecutive Alkylation/Palladium-Catalyzed Functionalization Strategy. Journal of Combinatorial Chemistry. 2005 Jul-Aug;7(4), 526-529. DOI: 10.1021/cc050036t.

Alvarado M., Coelho A., Masaguer CF., Raviña E., Brea J., Padín JF., Loza MI. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics. Bioorganic & Medicinal Chemistry Letters. 2005 Jun;15(12):3063-6. DOI: 10.1016/j.bmcl.2005.04.022

Panjehpour M., Castro M., Klotz KN. Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal. Br J Pharmacol. 2005 May;145(2):211-8. DOI: 10.1038/sj.bjp.0706180.

Coelho, A., Novoa, H., Peeters, OM., Blaton, N., Alvarado, M., Sotelo, E. Pyridazine derivatives. Part 40: Reactivity of 5-alkynylpyridazin-3(2H)-ones toward hydrochloric acid. Tetrahedron. 2005 May;61(20), 4785-4791. DOI: 10.1016/j.tet.2005.03.021.

Candal EM., Caruncho HJ., Sueiro C., Anadon R., Rodriguez-Moldes I. Reelin expression in the retina and optic tectum of developing common brown trout. Dev Brain Res. 2005 Feb; 154: 187-19. DOI: 10.1016/j.devbrainres.2004.10.014. Epub 2004 Dec 28.

Coelho, A., Sotelo, E., Novoa, H., Peeters, OM., Blaton, N., Raviña, E. Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalyzed reactions. Tetrahedron. 2004 December 20;60(52), 12177-12189. DOI: 10.1016/j.tet.2004.10.014. In Press.

Pardo M, Piñeiro A., de la Fuente M ., García A., Sripadi P., Zitzmann N., Dwek RA., Sánchez-Salorio M., Domínguez F., Capeans C. Abnormal cell cycle regulation in primary human uveal melanoma cultures. Journal of Cellular Biochemistry. 2004 Nov 1;93, 708-720. DOI: 10.1002/jcb.20230.

Carotti A., Stefanachi A., Raviña E., Sotelo E., Loza MI., Cadavid MI., Centeno N., Nicoletti O. 8-Substituted-9-deazaxanthines as adenosine receptor ligando: design, síntesis and structure-affinity relationships at A2B. European Journal of Medicinal Chemistry. 2004 Oct;39(10):879-87. DOI: 10.1016/j.ejmech.2004.07.008.

García A., Zitzmann N., Watson SP. Analyzing the platelet proteome. Seminars in Thrombosis and Hemostasis. 2004 Aug;30:485-489. DOI: 10.1055/s-2004-833483.

Bosch MP., Campos F., Niubó I., Rosell G., Díaz JL., Brea JM., Loza MI., Guerrero A. Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor. Journal of Medicinal Chemistry. 2004 Jul;47(16):4041-53. DOI: 10.1021/jm031143.

Cordero L., Cadavid MI., Fernández-Llimós F., Díaz C., Sanz F., Loza MI. Continuing education and community pharmacists of Galicia: An opinión study. PWS Pharmacy World & Science. 2004 Jun;26 (3): 173-177. DOI: 10.1023/B:PHAR.0000026807.59766.ae.

García A., Prabhakar S., Brock CJ., Pearce AC., Dwek RA., Watson SP., Hebestreit HF., Zitzmann N. Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry. Proteomics. 2004 Mar;4:656-668. DOI: 10.1002/pmic.200300665.

Pérez-Costas E., Meléndez-Ferro M., Pérez-García C., Caruncho HJ., Rodicio MC. Reelin immunoreactivity in the adult sea lamprey brain. J Chem Neuroanat. 2004 Mar;27: 7-21. DOI: 10.1016/j.jchemneu.2003.08.005.

García A., Prabhakar S., Hughan S., Anderson TW., Brock CJ., Pearce AC., Dwek RA., Watson SP., Hebestreit HF., Zitzmann N. Differential proteome analysis of TRAP-activated platelets: involvement of Dok-2 and phosphorylation of RGS proteins. Blood. 2004 Mar;103:2088-2095. DOI: dx.doi.org/10.1182/blood-2003-07-2392. Epub 2003 Nov 26.

Caro Y., Torrado M., Masaguer CG., Raviña E., Padín F., Brea J., Loza MI. Chemoenzymatic syntesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potencial atypical antipsychotics. Bioorgaic & Medicinal Che mistry Letters. 2004 Feb;14:585-589. DOI: 10.1016/j.bmcl.2003.11.064.

Coelho, A., Sotelo, E., Fraiz, N., Yanez, M., Laguna, R., Cano, E., Raviña, E. Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Bioorganic Medicinal Chemistry Letters. 2004 Jan;14(2), 321-324. DOI: 10.1016/j.bmcl.2003.11.009

Veldic M., Caruncho HJ., Liu WS., Davis J., Satta R., Grayson DR., Guidotti A., Costa E. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proc Natl Acad Sci U S A. 2004 Jan;101: 348-35. DOI: 10.1073/pnas.2637013100. Epub 2003 Dec 18.

Caruncho HJ., Dopeso-Reyes I., Loza MI., Rodríguez MA. GABA, Reelin, and the neurodevelopmental hypothesis of schizophrenia. Critical ReviewsTM in Neurobiology. 2004 Jan 6;16(1-2):25-32. DOI: 10.1615/CritRevNeurobiol.v16.i12.20.

Domínguez E., Padín F., Cadavid MI., Loza MI. Integración del Estudio Farmacogenético y Farmacogenó mico de la Esquizofrenia (EFFE) en la Red INBIOMED. Informática y Salud. 2004;46:38-40. In Press.

Nieto RM., Coelho A., Martínez A., Stefanachi A., Sotelo E., Raviña E. Synthesis of 1-substituted-6-methyluracils. Chemical & Pharmaceutical Bulletin. 2003 Sep;51(9), 1025-1028. DOI: 10.1248/cpb.51.1025.

Villazón M., Enguix MJ., Tristán H., Honrubia MA., Brea J., Maayani S., Cadavid MI., Loza MI. Different pharmacological properties of two equipotent antagonists (clozapine and rauwolscine) for 5-HT2B receptors in rat stomach fundus. Biochemical Pharmacology. 2003 Sep;66(6):927-937. DOI: 10.1016/S0006-2952(03)00426-X. Epub 2003 Jul 12.

Enguix MJ., Sánchez L., Villazón M., Brea J., Tristán H., Cadavid MI., Loza MI. Differential regulation of rat peripheral 5-HT2A and 5-HT receptors systems: influence of drug treatment. Naunyn-Schmiedeberg's archives of pharmacology. 2003 Aug;368(2):79-90. DOI: 10.1007/s00210-003-0775-7. Epub 2003 Jun 15.

Vilardaga JP., Bünemann M., Krasel C., Castro M., Lohse MJ. Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nat Biotechnol. 2003 Jun 15;21(7):807-12. DOI: 10.1038/nbt838.

Sotelo E., Coelho A., Raviña E. Pyridazine derivatives Part 34: Retro-ene-assisted palladium-catalyzed synthesis of 4,5-disubstituted-3(2H)-pyridazinones. Tetrahedron Letters. 2003 June 9;44(24), 4459-4462. DOI: 10.1002/chin.200337125.

Sotelo E., Coelho A., Raviña E. Pyridazine derivatives 32: Stille-based approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones. Chemical & Pharmaceutical Bulletin. 2003 Apr;51(4), 427-430. DOI: 10.1248/cpb.51.427.

Dong E., Caruncho H., Liu WS., Smalheiser NR., Grayson DR., Costa E., Guidotti A. A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proc Natl Acad Sci U S A. 2003 Apr 29;100: 5479-5484. DOI: 10.1073/pnas.1031602100. Epub 2003 Apr 21.

Brea J., Christian F., Villazón M., Cadavid MI., Raviña E., Fontaine F., Dezi C., Pastor M., Sanz F., Loza MI. Conformationally constrained butyrophenones as new pharmacological tools to study 5-HT2A and 5-HT2C receptor behaviorus. European Journal of Medicinal Chemistry. 2003 Apr;38(4):433-440. DOI: 10.1016/S0223-5234(03)00054-0.

Coelho A., Sotelo E., Raviña E. Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones. Tetrahedron. 2003 March 31;59(14), 2477-2484. DOI: 10.1016/S0040-4020(03)00263-1.

Orallo F., García-Ferreiro T., Enguix MJ., Tristan H., Fdez-Masaguer C., Raviña E., Cadavid MI., Loza MI. In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known a1-adrenoceptor antagonist. Vascular Pharmacology. 2003 Feb;40(2):97-108. DOI: 10.1016/S1537-1891(02)00337-3

González-Gómez JC., Santana L., Uriarte E., Brea J., Villazón, Loza MI., De Luca M., Rivas ME., Montenegro GY., Fontenla JA. New arylpiperazine derivatives with higt affinity for Alpha1A, D2 and 5-HT2A receptors. Bioorganic & Medicinal Chemistry Letters. 2003 Jan 20;13(2):175-178. DOI: 10.1016/S0960-894X(02)00933-2.

Castro M., Dicker F., Vilardaga JP., Krasel C., Bernhardt M., Lohse MJ. Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins. Endocrinology. 2002 Oct;143(10):3854-65. DOI: 10.1210/en.2002-220232.

Rodríguez MA., Caruncho HJ., Costa E., Pesold C., Liu WS., Guidotti A. In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas. J Comp Neurol. 2002 Sep 23;451: 279-288. DOI: 10.1002/cne.10341.

Villazón M., Padín JF., Cadavid MI., Enguix M., Tristán H., Orallo F., Loza MI. Functional Characterization of Serotonin Receptors in Rat Isolated Aorta. Biological and Pharmaceutical Bulletin. 2002 May;25(5):584-590. DOI: 10.1248/bpb.25.584.

Honrubia M., Rodrigo J., Cadavid MI., Calleja JM., Sanz F., Loza MI. Influence of pH on the binding of diphenylmethylenepiperidines by 5-HT2B receptors in rat stomach fundus. Chemicall & Pharmaceutical Bulletin. 2002 Mar;50(3):395-8. DOI: 10.1248/cpb.50.395.

Brea J., Rodrigo J., Carrieri A., Sanz F., Cadavid MI., Enguix M., Villazón M., Mengod G., Caro Y., Massaguer CF., Raviña E., Centeno NB., Carotti A., Loza MI. New serotonina 5-HT2A, 5-HT2B and 5-HT2C receptor antagonists: synthesis, pharmacology, 3D QSAR and molecular modelling of (aminoakyl) benzo and heterocycloalkanones. Journal of Medicinal Chemistry. 2002 Jan 3;45(1):54-71. DOI: 10.1021/jm011014y

Pastor M., Benedetti P., Carotti A., Carrieri A., Díaz C., Herráiz C., Hölje H-D., Loza MI., Opresa R., Padín F., Pubill F., Sanz F., Stoll F. & the LINK3D consortium. Distant collaboration in drug discovery: The LINK3D project. Journal of Computer Aided Molecular Design 10 January 2003. 2002 Nov;16(11):809-818. DOI: 10.1023/A:1023884712617.

CONFERENCES

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Iria Gómez-Tourino, Jose Manuel Brea-Floriani, Eduardo Dominguez-Medina, Alejandro Rodriguez-Rodriguez, Mabel Loza-García. Identification of Novel and Repurposing Drugs for the Reduction of IL-1β and TNF-α Secretion by Inflamed Cells: Proof of Concept in Rheumatoid Arthritis Comunicación Oral (virtual). Federation of Clinical Immunology Societies Congress 2020. 28-31 Octubre, 2019. San Francisco (Virtual).

Alejandro Rodríguez Rodríguez; Eduardo Domínguez Medina; José Manuel Brea Floriani; Mabel Loza García; Iria Gómez Touriño. Search for immunomodulatory agents by screening small molecule libraries Comunicación Oral (virtual). II Annual CiMUS Workshop. 12 Julio, 2019. Santiago de Compostela, España.

Gómez Touriño, Iria; Mera Varela, Antonio; Gómez-Reino Carnota, Juan Jesús; Loza García, Mabel. Integration of Immunology and Pharmacology for the search of novel treatments for immune-related diseases Comunicación Oral (virtual). BioIntegraSaude congress. 14 Mayo, 2019. Santiago de Compostela, España.

V. Santos-Rosales, I. Ardao, J. Fernández, C. Alvarez-Lorenzo, A.L. Oliveira, A. Rege, C.A. García-González. Dual-porous polysaccharide aerogel processing for biomedical applications Poster. 6th EPNOE International Polysaccharide Conference. 2nd Prize for the Best Collaborative Work of the conference. 21-25 October, 2019. Aveiro, Portugal.

C. López-Iglesias, I. Ardao, J. Barros, P. Gurikov, I. Smirnova, C.A. García-González. Highly porous polysaccharide-based formulations for wound treatment. Poster - 1st Prize for the Best Collaborative Work of the conference. Poster. 6th EPNOE International Polysaccharide Conference. 21-25 October, 2019. Aveiro, Portugal.

Areias F, Correia C, Rocha A, Brea J, Castro M, Loza MI, Proença MF, Carvalho MA. 2-Aryladenine derivatives as potent scaffolds for A1, A3 and dual A1/A3 adenosine receptor antagonists: synthesis and structure-activity relationships. Poster. 1st EUROPEAN PURINE MEETING. Septiembre 4-6, 2019. Santiago de Compostela, Spain.

R. Prieto, M. Chotalia, M. Majellaro, M. J. Núñez, S. Novio, J. Azuaje, C. García-Santiago, M. Freire-Garabal, M.I. Loza, J. Brea, H. Gutiérrez de Terán, X. García-Mera1 and E. Sotelo. A2B Antagonist as antimetastatic agents: design, synthesis and optimization of novel chemotypes. Poster First European Purine Club Meeting 2019. 4-6 September 2019. Santiago de Compostela, Spain

Triana-Martínez F., Blanco-López MR., Loza MI., Carracedo A., Domínguez E., Blanco-López MR. Identifying small molecule degraders of promyelocytic leukemia (PML) to targe triple negative breast cancer.Poster. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Morán L., Barrachina M., Izquierdo I., Hermida-Nogueira L., Piña R., Moreira D., Domínguez E., Loza MI., García A. High throughput screening of small molecule inhibitors of CLEC-2 platelet receptor: searching for a novel anti-platelet agent. Poster. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Veiga S., Goiricelaya E., Martínez AL., Redondo C., Pensado A., Domínguez E., Sánchez L., Diéguez C., Loza M., Carracedo A., Allegue C. Development of celular models of acute neuropathic pain by crispr-CAS9.Poster. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Cimadevila M., Iglesias A., Cadavid MI., Brea J., Loza García MI. Characterization of the essential role of C148A-C227A disulfide bridge in human 5-HT2A binding capacity.Poster. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Castro M, Marti-Solano M, Selent J, Silva AG. Quantification of ligand bias and validation of structural hypotheses on functional selectivity at serotonin 5-HT2A receptor Poster. COST Action "CA18133 - European Research Network on Signal Transduction (ERNEST)". First ERNEST General Meeting. 2019. Belfast, United Kingdom.

Gómez-García L., Gómez S., Cadavid MI., Brea JM., Loza MI. Typical and atypical antipsychotics differentially modulates D2/5-HT2A heterooligomer signaling.Poster. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Rodríguez Rodríguez A., Domínguez E., Brea JM., Loza MI., Gómez I. Identification of novel anti-inflamatory small-drug molecules.Poster. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Fernández Varela C., Anfray C., Mainini F., Gandoy S., Crecente-Campo J., Loza MI., Brea JM., Allavena P., Torres Andón F., Alonso MJ. Resiquimod-loaded nanocapsules for tumor associated macrophages reprogramming to treat lung and pancreatic cancer.Oral Communication. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Triana-Martínez F., Picallos-Rabina P., Da Silva-Álvarez S., Rodilla V., Ikonomopoulou M., Fernández-Marcos P., Del Pino P., Arribas J., Vidal A., González-Barcia M., Serrano M., Loza MI., Domínguez E., Collado M. Identification of Cardiac Glycosides as a new class of senolytic compounds and senolytic therapy in cancer.Oral Communication. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Álvarez Coiradas E., R Munteanu C., Gómez Touriño I., Díaz Sáez L., Huber K., Roberts R., Loza MI., Domínguez E. Targeting the IL-17 Inflammatory Pathway of psoriasis with small molecules.Oral Communication. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Cimadevila Fondevila M., Martínez Rodríguez AL., Iglesias A., Cadavid MI., Brea JM., Loza MI. Characterization of the essential role of C148-C227 disulfide bridge in human –HT2A binding capacity. Poster. II Annual CiMUS Workshop. 12 July 2019, Santiago de Compostela, Spain.

Lidia Hermida-Nogueira, María N. Barrachina, Irene Izquierdo, Serena Lacerenza, Susana Bravo, Azucena Castrillo, Ángel García. Platelet storage lesion: Proteomic analysis of extracellular vesicles derived from platelets treated with Mirasol. Poster. ISTH 2019. 6-10 July. Melbourne - Australia.

Irene Izquierdo, María N. Barrachina, Lidia Hermida-Nogueira, Vanessa Casas, Serena Lacerenza, Johannes A. Eble, Joaquín Abián, Montserrat Carrascal, Ignacio Casal, Ángel García. Extensive tyrosine phosphoproteomic analysis of the CLEC-2 signalling cascade in human platelets: new players on the team. Oral Communication. ISTH 2019. 6-10 July. Melbourne - Australia.

María N. Barrachina, Irene Izquierdo, Lidia Hermida-Nogueira, Luis Moran, Aurelio M. Sueiro, Vanessa Casas, Albert Casanovas, Felipe F. Casanueva, Joaquín Abián, Montserrat Carrascal, María Pardo, Ángel García. The integrin aIIbb3 signalling pathway is hyperactivated in platelets from obese patients: a phosphoproteomic study. Poster. ISTH 2019. 6-10 July. Melbourne - Australia.

Álvarez Coiradas E., R Munteanu C., Gómez Touriño I., Díaz Sáez L., Huber K., Roberts R., Loza García MI., Domínguez E. Identification and Validation of two small Molecules Targeting the IL-17 Inflammatory Pathway. Oral Communication. 39th Spanish Society of Pharmacology Meeting. 3-5 July 2019, Las Palmas, Spain.

Gómez García L., Gómez S., Cadavid MI., Brea JM., Loza MI. Typical and atypical antipsychotics differentially modulates D2/5-HT2A heterooligomer signaling. Poster. 39th Spanish Society of Pharmacology Meeting. 3-5 July 2019, Las Palmas, Spain.

Martínez Rodríguez AL., Brea Floriani JM., Merlos M., Pérez A., Burgueño J., Loza MI. Development of a translational in vitro assay for iatrogenic neuropathic pain. Poster. 39th Spanish Society of Pharmacology Meeting. 3-5 July 2019, Las Palmas, Spain.

Cimadevila M., Martínez AL, Iglesias A., Cadavid MI., Brea Floriani JM:, Loza García MI. Essential role of C148-C227 disulfide bridge in human –HT2A receptor functionality and trafficking. Oral Communication. 39th Spanish Society of Pharmacology Meeting. 3-5 July 2019, Las Palmas, Spain.

Brea JM., Campos F., Pérez-Díaz A., Cuadrado E., Iglesias-Rey R., Da Silva-Candal A., Sobrino T., Castillo J., Loza MI. Therapeutic potential of blood glutamate grabbing in stroke: a proof of concept. Oral Communication. 6th ECBS/LS-EuChemS Meeting. 3-5 July 2019, Madrid, Spain.

Prieto R., Piay N., Triñanes D., Azuaje J., Soilán J., Brea JM., Loza MI., Contino A., Stefanachi A., Sotelo E. Discovery of Novel Rimonabant-like peripheral selective CB1 ligands. Poster. 6th ECBS/LS-EuChemS Meeting. 3-5 July 2019, Madrid, Spain.

Gómez-García L., Gómez S., Villar M., Cadavid MI., Brea JM., Loza MI. Hallucinogenic ligand (±)DOI modulate agonist and antagonist D2 signaling by activating 5-HT2A protomers of a 5-HT2A/D2 heterooligomer. Poster. 6th ECBS/LS-EuChemS Meeting. 3-5 July 2019, Madrid, Spain.

Martínez AL., Pérez A., Brea JM., Monroy X., Merlos M., Burgueño J., Loza MI. Employment of novel phenotypic in vitro models for high throughput screening of new drugs for neuropathic pain. Poster. 6th ECBS/LS-EuChemS Meeting. 3-5 July 2019, Madrid, Spain.

Cimadevila M., Iglesias A., Cadavid Torres MI., Brea JM., Loza MI. Using dithiothreitol as a pharmacological tool to study the effect of extracellular disulphide bridges in serotonin 2A receptor functionality. Poster . 6th ECBS/LS-EuChemS Meeting. 3-5 July 2019, Madrid, Spain.

Álvarez-Coiradas E., R. Munteanu C., Gómez-Touriño I., Díaz-Sáez L., Huber K., Roberts R., Loza García MI., Domínguez E. Identification of small molecules targeting the IL-17 inflammatory pathway. Poster. 6th ECBS/LS-EuChemS Meeting. 3-5 July 2019, Madrid, Spain.

García Silva A, Martí Solano M, Selent J, Loza García MI, Castro Pérez M. Quantification of functional bias of serotonin 5-HT2A receptor agonists and validation of structural hypotheses on functional selectivity at 5-HT2A receptor. Poster. 39th Spanish Society of Pharmacology Meeting. 3-5 July 2019. Las Palmas de Gran Canaria, Spain.

C. López-Iglesias, I. Ardao, A. Concheiro, C. Alvarez-Lorenzo, C.A. García-González. Drug-loaded chitosan aerogels prepared by supercritical CO2-assisted drying for biomedical applications. Poster. 17th European Meeting on Supercritical Fluids (EMSF 2019). 8-11 April, 2019. Ciudad Real, Spain.

Iria Gómez Touriño; Yogesh Kamra; Anna Lorenc; Mark Peakman Combined deep and single cell sequencing of autoantigen-specific CD4+ T cell receptor beta clonotypes shows unexpected publicity and disease-related differentiation. Póster. Immunology of Diabetes Society 16th International Congress. 25-29 October, 2018. London, UK.

Sefina Arif; Iria Gómez Touriño; Yogesh Kamra; Timothy Tree; Daisy Melandri; Caroline Hull; Anna Lorenc; Mark Peakman. GAD-Alum immunization induces de novo priming and expansion of bi-functional/hybrid CD4 T cell responses. Poster. Immunology of Diabetes Society 16th International Congress. 25-29 October, 2018. London, UK.

R. Starbird, R. Zamora-Sequeira, I. Ardao, C.A. García-González, L. Alvarado, G. Saenz, E. Avendano. Mechanical and electrical characterization of a conductive porous material using a biopolymer aerogel as template and its potential application in biomedical field. Poster. 4th International Seminar on Aerogels 2018. 25-27 September, 2018. Hamburg, Germany.

Irene Izquierdo, María N. Barrachina, Eduardo Domínguez, Lidia Hermida-Nogueira, Amparo Pérez, Mabel Loza, Ángel García. The molecule KI3112 as a potential antiplatelet agent able to inhibit GPVI activation. Poster. EUPLAN 2018. 19-21 September. Brujas. Belgium.

María N. Barrachina, Aurelio M. Sueiro, Irene Izquierdo, Lidia Hermida-Nogueira, Richard W. Farndale, Masaaki Moroi, Stephanie M. Jung, María Pardo, Ángel García. GPVI surface expression and signaling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity. Póster. EUPLAN 2018. 19-21 September. Brujas. Belgium.

María N. Barrachina, Aurelio M. Sueiro, Vanessa Casas, Irene Izquierdo, Lidia Hermida-Nogueira, Esteban Guitián, Felipe F. Casanueva, Joaquín Abián, Montserrat Carrascal, María Pardo, Ángel García. A combination of proteomic approaches identifies a panel of circulating extracellular vesicle proteins related to the risk of suffering cardiovascular disease in obese patients. Oral Communication. EUPLAN 2018. 19-21 September. Brujas. Belgium.

Gómez-García L., Gómez S., Cadavid MI,Brea J., Loza MI. Hallucinogenic ligand(±)DOI modulate dopamine D2 signaling by activating 5-HT2A protomers of a 5-HT2A/D2 heterooligomer. Poster. 1st Meeting in Translational Pharmacology. 19-22 June 2018. Santiago de Compostela, Spain.

Silva AG, Loza MI, Costas J, Halls M, Castro M. Spatiotemporal location of the fractalkine receptor CX3CR1 and its natural genetic double variant V249I/T280M. Poster. XXXVIII Congreso de la Sociedad Española de Farmacología. 19-22 June 2018. Santiago de Compostela, España.

Vila L, Moreno L, Silva AG, Castro M, Loza MI, Sanz MJ, Cortes D, Cabedo N. Aporphine, 1-benzylisoquinoline and phenanthrene alkaloids as D2-dopaminergic ligands. Oral communication. XXXVIII Congreso de la Sociedad Española de Farmacología. 19-22 June 2018. Santiago de Compostela, Spain.

Cimadevila M., Pérez-Lozano A., Iglesias A., Brea J., Cadavid MI, Loza MI. Cysteine 148 is a key residue in human 5-HT2A receptor expression. Poster. 1st Meeting in Translational Pharmacology. 19-22 June 2018. Santiago de Compostela, Spain.

Ardao I., Ramírez-Sánchez K., Cadavid MI., Starbird-Pérez R., Loza MI. Acetylcholinesterase immobilization on microplates for high-throughput screening of inhibitors. Poster. 1st Meeting in Translational Pharmacology. 19-22 June 2018. Santiago de Compostela, Spain.

Iglesias A., Cimadevila M., Cadavid MI., Brea J., Loza MI. Serotonin-2A homodimers are needed for signalling via both phospholipase A2 and phospholipase C in transfected CHO cells. Poster. 1st Meeting in Translational Pharmacology. 19-22 June 2018. Santiago de Compostela, Spain.

Álvarez-Coiradas E., R. Munteanu C., Gómez-Touriño, Díaz-Sáez L., Huber K., Loza García MI, Domínguez E. Identification of small molecules targeting the IL-17 inflammatory pathway by label-free assays. Poster. 1st Meeting in Translational Pharmacology. 19-22 June 2018. Santiago de Compostela, Spain.

Irene Izquierdo, María N. Barrachina, Lidia Hermida-Nogueira, Vanessa Casas, Montserrat Carrascal, Joaquín Abián, Ángel García. Depicting the platelet CLEC-2 signalling cascade by a phosphotyrosine proteomic approach: impact of secondary mediators. Poster. XII European Proteomics Society (EUPA) . 16-20 de June 2018. Santiago de Compostela. Spain.

Irene Izquierdo, María N. Barrachina, Lidia Hermida-Nogueira, Vanessa Casas, Montserrat Carrascal, Joaquín Abián, Ángel García. Extensive proteomic analysis of lipid rafts composition on resting and activated platelets. Poster. XII European Proteomics Society (EUPA) . 16-20 de June 2018. Santiago de Compostela. Spain.

Lidia Hermida-Nogueira, Irene Izquierdo, María N. Barrachina, Susana Bravo, Juan Blanco, Pedro Diz, Ángel García. Secretome analysis of leukocyte-platelet rich fibrin membranes used in wound healing. Póster. XII European Proteomics Society (EUPA) Congress. 16-20 de June 2018. Santiago de Compostela, Spain.

Silva AG, de la Fuente RA, Izquierdo AG, Loza MI, Costas J, Halls M, Castro M. Spatiotemporal signaling and location of fractalkine receptor CX3CR1 and its natural genetic double variant V249I/T280M. Oral communication. I Annual CIMUS Workshop. 15 June 2018. Santiago de Compostela, Spain.

R. Starbird, R. Zamora, I. Ardao, C.A. García-González. An impedance model for a conductive organic porous material using biopolymers as template – Effect of the biopolymer as doping agent. Oral communication. 2018 MRS Spring Meeting & Exhibit – Biomaterials for Tissue Interface Regeneration. 2-6 April, 2018. Phoenix, USA.

R. Zamora, I. Ardao, R. Starbird, C.A. García González. Development of nanostructured systems based on poly (3,4-ethylenedioxythiophene) (PEDOT) aerogels for biomedical applications. Poster. 10th World Congress of Chemical Engineering (WCCE10). 1-5 de October 2017, Barcelona, Spain.

Astolfi A., Manfroni G., Cannalire R., Bührmann M., Brea J., Desantis J., Loza MI., Rauh D., A. Laufer S., Cecchetti V., L. Barreca M. A multidisciplinary approach to the Discovery of p38α MAPK Inhibitors. Oral Communication. 7th Meeting of the Paul Ehrlich Medchem Euro-PhD Network. 25-27 August 2017. Vienna, Austria.

Martínez A.L., Monroy X., Brea J., Merlos M., Burgueño J., M.I. Loza. Development of phenotypic in vitro models of pain in early drug discovery. Poster. 37th National Meeting of the Spanish Society of Pharmacology (SEF) 18-21 July 2017. Barcelona, Spain.

Iglesias A., Elezgarai SR., Barreca ML., Moreno J., García-Martínez S, Castilla J, Loza M, Biasini E, Domínguez E, Requena JR. Identification of pharmacological chaperones for the cellular prion protein by dinamic mass redistribution (DMR) screening. Poster. 37th National Meeting of the Spanish Society of Pharmacology (SEF) 18-21 July 2017. Barcelona, Spain.

Álvarez-Coiradas E., Gómez-Touriño I., Munteanu C., Loza, MI., Domínguez, E. Discovery of small molecules for IL-17 mediated inflammatory diseases. Poster. 37th National Meeting of the Spanish Society of Pharmacology (SEF) 18-21 July 2017. Barcelona, Spain.

María N. Barrachina, Aurelio M. Sueiro, Felipe F. Casanueva, María Pardo, Ángel García. A combination of biochemical and functional approaches shows a hyperactivation of Src family kinases-mediated signaling pathways in platelets from obese patients. Poster. XXVI ISTH congress. 8-13 July 2017. Berlin. Germany.

Pujol E., Pizarro J., Valverde E., Codony S., Ginex T., Loza MI., Brea J., Pérez B., Sáez E., Oyarzabal J., Javier Luque F., Leiva R., Vázquez-Carrera M., Vázquez S. Novel soluble epoxide hydrolase inhibitors featuring A 2-Oxaadamantanemoiety II: aromatic derivatives. Poster. 10th Joint Meeting on Medicinal Chemistry. 25-28 June 2017. Dubrovnik - Croacia.

Kaczor AA, Targowska-Duda KM, Kruk-Słomka M, Silva AG, Kolb P, Poso A, Biała G, Castro M. In vitro, in vivo and molecular modeling studies of n-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1h-indazole-3-carboxamide (D2AAKk3) as a potential antipsychotic. Poster. 10th Joint Meeting on Medicinal Chemistry (JMMC 2017). 25-28 June 2017 Dubrovnik. Croacia.

Barrachina M.N, Izquierdo I, Hermida-Nogueira L, Calderón-Cruz B, Sueiro A.M, Casanueva F.F, Pardo M, García A. Platelets from obese patients show hyperactivation of Src family kinases-mediated signaling pathways. Oral Communication. V Jornadas de Jovenes Investigadores en Proteómica. 19-20 June. 2017, Toledo, Spain.

González García A, Gómez García L, Cadavid MI, Loza MI, Brea JM. Dynamic Mass Redistribution phenotypic assay for identifying ligands active at GPR35 receptors. Poster. XXXVII Congreso de la Sociedad Española de Farmacología. 18-21 June de 2017, Barcelona, Spain.

Silva AG, Parraga J, Vila L, Sanz MJ, Loza MI, Castro MA, Cortes D, Cabedo N. Synthesis of new 1-substituted isoquinolines with potential anti-Parkinson activity. Poster. XXXVII Congreso de la Sociedad Española de Farmacología. 18-21 June de 2017, Barcelona, Spain.

Castro M, García-Silva A, de la Fuente RA, Izquierdo AG, Rodríguez J, Loza MI. Farmacología molecular de dianas terapéuticas tipo GPCR: señalización intracelular de variantes genéticas naturales del receptor de quimiocinas CX3CR1 y caracterización de ligandos y mecanismos de acción novedosos en GPCRs. Poster. Jornadas BioIntegraSaúde 2017 – BIS2017. 30 May 2017, La Coruña.

Castelo Domínguez R, Sardiña Rivera E, Castro Pérez MA, García Ramos MR, Gayoso Diz P. Adecuación de prescripción en personas mayores con IRC: herramienta de ayuda a la toma de decisiones. Oral communication. XXXVII Congreso de la Sociedad Española de Medicina de Familia y Comunitaria.4-5 May 2017, Madrid. Spain.

Kaczor AA, Targowska-Duda KM, Kruk-Słomka M, Silva AG, Kolb P, Poso A, Biała G, Castro M. Novel antipsychotics identified in structure-based virtual screening. Oral communication. 3rd International Conference on New Trends in Chemistry. 28-30 April, 2017 Helsinki. Finland.

Kaczor AA, Targowska-Duda KM, Kruk-Słomka M, Silva AG, Kolb P, Poso A, Biała G, Castro M. In vitro, in vivo and molecular modeling studies of D2AAK2, a non-basic dopamine D2 receptor antagonist, as a potential antipsychotic. Poster. COST Action GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network. GLISTEN SYMPOSIUM. 29-31 March 2017, Porto. Portugal.

Azuaje J, Salgado A, Escalante L, López P, Iglesias A, de la Fuente RA, Pérez-Rubio JM, García D, Pérez D, Stępniewski TM, García-Mera X, Brea JM, Selent J, Castro M, Loza MI, Sotelo E. Development of fluorescent probes that target serotonin 5-HT2B receptors. Poster. COST Action GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network. GLISTEN SYMPOSIUM. 29-31 March 2017, Porto. Portugal.

Castro M, García-Silva A, De La Fuente RA, Izquierdo AG, Loza MI, Costas J. Signaling of the fractalkine receptor CX3CR1 and its natural genetic variants: impact of receptor non-synonymous single nucleotide polymorphisms. Poster. COST Action GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network. GLISTEN SYMPOSIUM. 29-31 March 2017, Porto. Portugal.

García-Silva A, de la Fuente RA, Izquierdo AG, Loza MI, Costas J, Castro M. Signaling of the fractalkine receptor CX3CR1 and its natural genetic variants: impact of receptor non-synonymous single nucleotide polymorphisms. Poster. Molecular Pharmacology Gordon Research Conference: "GPCRs: From Single Molecules to New Forms of Treatment". 2017, Lucca, Italy.

Yempala T., Acevedo-Fuentes W., Brea J., Loza MI., K Cassels B. Exploring the 5-HT2 receptor extended pocket with dibenzofuran derivatives. Poster. 8th Brazilian Symposium in Medicinal Chemistry 27-30 November 2016, Rio de Janeiro.

Acevedo-Fuentes WA., Brea J., Loza MI., Cassels BK. Effect of N-substitution of Lorcaserin (and analogs) on 5-HT2 receptor affinities: looking for new anorexigenic drugs. Poster. XXXVIII Congreso Annual de la Sociedad de Farmacología de Chile. 26-29 November 2016, Chile.

Toro-Sazo M. Brea J., Loza MI., Cassels BK. Use of N-benzyltryptamines to explore the 5-HT2 receptor extended binding pocket. Poster. XXXVIII Congreso Annual de la Sociedad de Farmacología de Chile. 26-29 November 2016, Chile.

Nogueira U., Domínguez E., Loza MI., Blanco FJ., Caramés B. Identification of novel molecules targeting cartilage aging as osteoarthritis therapeutics. Poster. VIII Spanish Drug Discovery Network Meeting. 3-4 November 2016, Santiago de Compostela, Spain.

Cimadevila M., Iglesias A., Cadavid MI., Loza MI., Brea J. Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A. Poster. VIII Spanish Drug Discovery Network Meeting. 3-4 November 2016, Santiago de Compostela, Spain.

Iglesias A., González-García A., Elezgarai S., Veiga S., Bonetto V., Barreca ML., Moreno J., García-Martínez S., Eraña H., Castilla J., Loza M., Biasini E., Domínguez E., Requena JR. Identification of pharmacological chaperones for the cellular prion protein by dynamic. Poster. VIII Spanish Drug Discovery Network Meeting. 3-4 November 2016, Santiago de Compostela, Spain.

González-García A., Gómez-García L., Cadavid MI, Loza MI, Brea J. Dynamic Mass Redistribution phenotypic assay for identifying ligands active. Poster. VIII Spanish Drug Discovery Network Meeting. 3-4 November 2016, Santiago de Compostela, Spain.

Martínez A.L., Rodríguez-Penabad C., Villasuso B., Penin O., Loza MI., Cadavid MI. Pharmacoterapeutic monitoring and blood pressure control in community pharmacy. Oral Communication. XXXVI Congreso de la Sociedad Española de Farmacología. 16-18 September 2015, Valencia, Spain.

Nogueira Recalde U., Domínguez E., Blanco F., Loza MI., Caramés B. Identification of novel molecules targeting cartilage aging as osteoarthritis therapeutics. Oral Communication. XXXVI Congreso de la Sociedad Española de Farmacología. 16-18 September 2015, Valencia, Spain.

González García A., García Fernández AM., Brea Floriani JM., Martínez Gil A., Gil Ayuso-Gontan C., Loza García MI., Cadavid Torres MI. Maleimides derivatives as new PDE10A inhibitors or putative drugs for CNS diseases. Oral Communication. XXXVI Congreso de la Sociedad Española de Farmacología. 16-18 September 2015, Valencia, Spain.

Gómez Fernández S., López-Giménez JF., Varela MJ., Macía-Rivas MD., Cadavid MI., Brea J., Loza MI. A novel cell line for studying dopamine D2 and serotonin 5-HT2A heterodimerization. Oral Communication. XXXVI Congreso de la Sociedad Española de Farmacología. 16-18 September 2015, Valencia, Spain.

Cimadevila Fondevila M., Iglesias Fernández A., Azuaje Guerrero JA., Sotelo Perez E., Cadavid Torres MI., Brea Floriani JM, Loza García MI. Study of Homodimeric 5-HT2A Receptors Through the use of new Heterobivalent Ligand. Oral Communication. XXXVI Congreso de la Sociedad Española de Farmacología. 16-18 September 2015, Valencia, Spain.

García Silva A., Kaczor A., Loza MI., Kolb P., Poso A., Castro M. Characterization of novel competitive ligands at dopamine D2 receptors identified by virtual screening. Oral Communication. XXXVI Congreso de la Sociedad Española de Farmacología. 16-18 September 2015, Valencia, Spain.

Martínez AL., Brea J., Burgueño J., Merlós M., Monroy X., Vela JM., Cadavid MI., Loza MI. Development of phenotypical in vitro models in pain for early drug discovery. Oral Communication. XXXV Congreso de la Sociedad Española de Farmacología. 24-26 September 2014, Madrid, Spain.

Rodriguez Carracedo J., De la Fuente González R., Varela Lara I., Brea Floriani J., Rodríguez Díaz D., Gutiérrez de Terán H., Loza García MI., Castro Pérez MA. Residue HIS264 in extracelular loop 3 of adenosine A2A receptor is critical for the kinetics of ligand binding. Oral Communication. XXXV Congreso de la Sociedad Española de Farmacología. 24-26 September 2014, Madrid, Spain.

González Izquierdo A., Rodríguez Carracedo J., Lacivita E., Leopoldo M., Cadavid Torres MI., Loza García MI., Castro Pérez M. Pharmacological characterization of 5-HT7 selective arylpiperazine derivatives in rat primary astrocytes. Poster. XXXV Congreso de la Sociedad Española de Farmacología. 24-26 September 2014, Madrid, Spain.

De La Fuente González R., García Silva A., Moreno Guillén E., McCormick PJ., Martí Solano M., Cadavid Torres MI., Pastor Maeso M., Loza García MI., Selent J., Castro Pérez M. Investigation of the dimerization interface of the serotonin 5-HT2A receptor by computational and experimental approaches. Poster. XXXV Congreso de la Sociedad Española de Farmacología. 24-26 September 2014, Madrid, España.

Atanes P., Lacivita E., Rodríguez J., Brea J., Cadavid M.I., Loza M.I., Leopoldo M., Castro M. The arylpiperazine derivates LP-211 and MEL-9 are inactivating antagonists at human serotonin 5-HT7 receptors. XXXIV Congreso de la Sociedad Española de Farmacología. 16-19 September 2013, San Pedro del Pinatar, Spain.

De la Fuente-González, R.A., Atanez-Juiz P., Moreno Guillén E., McCornick P.J., Bruno A., Pastor M., Loza García M.I., Selent J., Castro Pérez M. Characterization of a serotonin 5-HT2A receptor mutated at the colesterol consensus motif. XXXIV Congreso de la Sociedad Española de Farmacología. 16-19 September 2013, San Pedro del Pinatar, Spain.

González Izquierdo A., De la Fuente González R.A., Atanes Juiz P., Rodríguez Carracedo J., Domínguez Medina E., Loza García MI., Costas Costas J., Castro Pérez M. Translocation of Beta-arrestin II by fractalkine at CX3CR1 receptors: impact of receptor non-synonymous single nucleotide polymorphisms (NSSNPS). XXXIV Congreso de la Sociedad Española de Farmacología. 16-19 September 2013, San Pedro del Pinatar, Spain.

González-García A., Val C., Brea J., Redondo M., Campillo N., Soteras I., Martínez A., Gil C., Loza MI., Cadavid MI. Unravelling the structural determinants for obtaining new PDE7 allosteric modulators. Poster. XXXIV Congreso de la Sociedad Española de Farmacología. 16-19 September 2013, San Pedro del Pinatar, Spain.

Iglesias A., Lage S., Castro M., Cadavid MI., Loza MI., Brea J. Identification of active compounds on serotonin 2A receptor (5-HT2A) by high thoughput screening. Poster. XXXIV Congreso de la Sociedad Española de Farmacología. 16-19 September 2013, San Pedro del Pinatar, Spain.

Rodríguez Carracedo J., Atanes Juiz P., Brea Floriani J., Cadavid Torres MI., Loza García MI., Castro Pérez M. Residence time of the novel antipsychotic lurasidone at serotonin 5-HT7 receptors. Poster. XXXIV Congreso de la Sociedad Española de Farmacología. 16-19 September 2013, San Pedro del Pinatar, Spain.

Lage S., Castro M., Loza MI., Cadavid MI., Brea J. Influence of different levels of reelin in the functionality of 5HT2A receptors in synaptosomes. Poster. XXXIV Congreso de la Sociedad Española de Farmacología. 16-19 September 2013, San Pedro del Pinatar, Spain.

Iglesias A., Cadavid MI., Loza MI., Brea J. Development of a multiplex assay for studying functional selectivity of human serotonin 5-HT2A receptors. Poster. 6th European Congress of pharmacology. 17-20 July 2012, Granada, Spain.

Lage S., Varela MJ., Cadavid MI., Loza MI., Brea J. Influence of levels of reelin in negative cooperativity and functionality of the 5-HT2A receptors in synaptosomes. Poster. 6th European Congress of pharmacology. 17-20 July 2012, Granada, Spain.

Val C., Brea J., Sotelo E., Cadavid MI., Loza MI. 2-Aminopyrimidine derivatives as selective A1 adenosine receptor antagonists. Poster. 6th European Congress of pharmacology. 17-20 July 2012, Granada, Spain.

González-García A., Val C., Redondo M., Gil C., Martínez A, Brea J, Loza MI, Cadavid MI. Thiophene and Furane derivatives as new PDE7 inhibitors or putative drugs for neurodegenerative diseases. Poster. 6th European Congress of pharmacology. 17-20 July 2012, Granada, Spain.

Nieto A., Brea J., Cadavid MI., Mestres J., Sánchez-Sellero I., Loza MI. Allosteric modulation of 5-HT2B receptors by celecoxib. Putative involvement in adverse drug reactions associated with coxibs. Poster. 6th European Congress of pharmacology. 17-20 July 2012, Granada, Spain.

Cuadrado E., Carpéné C., Mercader J., Loza MI., Cadavid MI., Brea J. Identification of novel SSAO/VAP-1 inhibitors by high-throughput screening. Poster. 6th European Congress of pharmacology. 17-20 July 2012, Granada, Spain.

Varela MJ., Castro M., Jenkins L., Cadavid MI., Loza MI., Milligan G., Brea J. Identification of novel species-selective ligands of the G protein-coupled receptor GPR35. XXXIII Congreso de la Sociedad Española de Farmacología. 3-5 October 2011. Málaga, Spain.

Loza MI., Brea J., Areias F., Castro M. 5-H2A receptors functional selectivity in drug discovery. Oral Communication. 2nd Iberic meeting on Medicinal Chemistry. 12-15 de June 2011, Porto, Portugal.

Carro L., Masaguer CF., Raviña E., Brea J., Loza MI. Synthesis and binding affinity of conformationally constrained butyrophenone analogues of haloperidol as potential atypical antipsychotics. Oral Communication. 2nd Iberic meeting on Medicinal Chemistry. 12-15 de June 2011, Porto, Portugal.

Insua I., Carro L., Masaguer CF., Brea J., Loza MI. Microwave-assisted synthesis of new triazole derivatives by click chemistry, as potential D3 receptor ligands. Poster. 2nd Iberic meeting on Medicinal Chemistry. 12-15 de June 2011, Porto, Portugal.

Senhoraes N., Areias F., Castro M., Brea J., Loza MI., Dias AM., Proença MF. Synthesis of 2,6,9-trissubstitued adenine scaffold for adenosine receptors. Poster. 2nd Iberic meeting on Medicinal Chemistry. 12-15 de June 2011, Porto, Portugal.

Lage S., Varela MJ., Brea J., Cadavid MI., Loza MI. Influence of reelin expression on the conformational distribution of 5-HT2A receptors. XXXIII Congreso de la Sociedad Española de Farmacología. 3-5 October 2011, Málaga, Spain.

Atanes P., Leopoldo M., Rodríguez J., Brea J., Loza MI., Castro M. Novel in vitro pharmacological behaviour of compounds active at serotonin 5-HT7 receptors stably expressed in HEK293 cells. XXXIII Congreso de la Sociedad Española de Farmacología. 3-5 October 2011, Málaga, Spain.

Brea J., Schmidt S., Sánchez J., Zorzano A., Cadavid MI., Loza MI. Identification of active compounds at DOR (Diabetes and Obesity Regulated) as putative antiobesity/antidiabetic drugs by High Throughput Screening. Poster. XXXIII Congreso de la Sociedad Española de Farmacología. 3-5 October 2011, Málaga, Spain.

Val C., Brea J., Gil C., Martínez A., Redondo M., Loza MI., Cadavid MI. Thiophene and Furane derivatives as new PDE7 inhibitors or putative drugs for CNS disorders. Poster. XXXIII Congreso de la Sociedad Española de Farmacología. 3-5 October 2011, Málaga, Spain.

Iglesias A., Brea J., Nespereira B., Gurwitz D., Cadavid MI., Loza MI. Lymphoblastoid cell viability, a novel tool for farmacological effect prediction. Poster. XXXIII Congreso de la Sociedad Española de Farmacología. 3-5 October 2011, Málaga, Spain.

Nieto A., Brea J., Rodríaguez F., Ballesteros J., Cadavid MI., Loza MI. Development of an automated methodology for measuring native GLP-1R activation useful for the screening of compounds with putative antidiabetic activity. Poster. XXXIII Congreso de la Sociedad Española de Farmacología. 3-5 October 2011, Málaga, Spain.

Rodríguez AM., Rosell G., Bujons J., Gutiérrez-de-Terán H., Rodríguez D., Brea JM., Loza MI., Guerrero A., Bosch MP. Synthesis, biological activity and molecular docking analysis of new adenosine A2A receptor agonists. Purines 2010. 30 May-2 June 2010, Tarragona, Spain.

Lage S., Varela MJ., Domínguez E., Brea J., Cadavid MI., Loza MI. Time and ligand dependency of conformational distribution of serotonin 5-HT2A receptors. Oral Communications. 32 Congreso de la Sociedad Española de Farmacología. 15-17 September 2010, León, Spain.

Varela MJ., Lage S., Caruncho HJ., Cadavid MI., Loza MI., Brea J. Effect of chronic treatment with typical antipsychotic haloperidol in 5-HT2A receptors expression in reeler mice. Poster. 32 Congreso de la Sociedad Española de Farmacología. 15-17 September 2010, León, Spain.

Nieto A., Brea J., Cadavid MI., Sanchez I., Mestres J., Loza MI., on behalf of the entire EU-ADR Consortium. Pharmacological fingerprint of selective inhibitors of COX2 (celecoxib, valdecoxib): prediction of adverse reactions. Poster. 32 Congreso de la Sociedad Española de Farmacología. 15-17 September 2010, León, Spain.

Atanes P., Nespereira B., Brea JM., Cadavid MI., Loza MI., Castro M. Study of the serotonin 5 HT2A receptor homodimer function in cell lines. Poster. 32 Congreso de la Sociedad Española de Farmacología. 15-17 September 2010, León, Spain.

Vieira AC., Loza MI., Nespereira B., Brea JM., Selent J., Pastor M., Castro M. Structural determinats on gpcrs relevant for the pharmacological profile of atypical antipsychotics. Poster. 32 Congreso de la Sociedad Española de Farmacología. 15-17 September 2010, León, Spain.

Costa M., Marinho E., Proença F., Areias F., Castro M., Brea J., Mestres J., Loza MI. Synthesis of novel chromene-based scaffolds for adenosine receptors. Oral Communication. 2º Encontro nacional de química terapéutica. 28-30 November 2010, Coimbra, Portugal.

Proença F., Magdi Z., Areias F., Loza MI., Mestres J. Synthesis of 2-aryl-8-oxopurines as novel antagonists for adenosine receptor subtypes. Poster. 2º Encontro nacional de química terapéutica. 28-30 November 2010, Coimbra, Portugal.

Marinho E., Costa M., Proença F., Areias F., Castro M., Brea J., Mestres J., Loza MI. bN-methyl piperazine: an important fragment for interaction with serotonine 5-HT2A receptors. Poster. 2º Encontro nacional de química terapéutica. 28-30 November 2010, Coimbra, Portugal.

Rico M., Castro M., Loza MI., Nespereira B. Comparison of different methods of RNA isolation for microarray-mediated transcriptional profile studies in neuronal cells treated with drugs. Poster. XXXI Congreso de la Sociedad Española de Farmacología. 16-18 September 2009. Sevilla, Spain.

Varela MJ., Brea J., Dopeso-Reyes IG., Caruncho HJ., Cadavid MI., Loza MI. Characterization of 5-HT2A serotonin receptors in synaptosomes of reeler mice. Poster. XXXI Congreso de la Sociedad Española de Farmacología. 16-18 September 2009. Sevilla, Spain.

Redondo M., Palomo V., Pérez DI., Campillo NE., Brea J., Cadavid I., Loza MI., Pérez C., Pérez-Castillo A., Gil C., Martínez A. Neuronal networks for the discovery of PDE7 inhibitors active on CNS diseases. Frontiers in Medicinal Chemistry. Emerging Targets, Novel Candidates and Innovative Strategies. 4-6 October 2009. Barcelona, Spain.

Rodríguez AM., Rosell G., Brea J., Loza MI., Guerrero A., Bosch MP. Development of New Adenosine A2A Receptor Agonists: Synthesis and Pharmacological Studies. Frontiers in Medicinal Chemistry. Emerging Targets, Novel Candidates and Innovative Strategies. 4-6 October 2009. Barcelona, Spain.

Yaziji V., Coelho A., Brea J., Loza MI., Gutierrez de Terén H., Rodríguez D., Sotelo E. Discovery of structurally simple, highly potent and selective A3 adenosien antagonists. Frontiers in Medicinal Chemistry. Emerging Targets, Novel Candidates and Innovative Strategies. 4-6 October 2009. Barcelona, Spain.

Raviña E., Barceló M., Fernández Masaguer C., Loza MI., Brea J., Pastor M., Sanz F. Synthesis, binding affinity and SAR of new n-containing heterocyclic analogues of haloperidol as potential atypical antipsychotic. Frontiers in Medicinal Chemistry. Emerging Targets, Novel Candidates and Innovative Strategies. 4-6 October 2009. Barcelona, Spain.

Crespo A., Val C., Yaziji V., Azuaje J., Coelho A., Brea JM., Loza MI., Cadavid MI., Sotelo E. Synthesis, biologial evaluation and SAR Studies of a hyghly diverse library of 2-aminopyrimidines as adenosine antagonists. Interfacing Chemical Biology, Natural Products and Drug Discovery. Poster. Internacional Conference on Medicinal Chemistry. 44èmes Rencontres internationales de Chimie Therapeutique. 2-4 July, 2008. Angers, France.

Brea J., Coelho A., Castro M., Cadavid MI. La experiencia de tres años de docencia en Farmacoterapia. Oral Communication. 2º Congreso Internacional de Educación Superior en Ciencias Farmacéuticas. 2008. Santiago de Compostela, Spain.

Areias F., Brea J., Gutierrez de Terán H., Correia C., Carvalho M., Provença F., Loza MI. Original Clozapine-like compounds. XXth International Symposium on Medicinal Chemistry. August 31–September 4, 2008. Vienna, Austria

Selent J., López L., Bauer-Mehren A., Fernández-Masaguer C., Loza MI., Sanz F., Pastor M. Integrated approach for the multireceptorial design of antipsychotic agents. XXth International Symposium on Medicinal Chemistry. August 31–September 4, 2008. Vienna, Austria

Bauer-Mehren A., Loza MI., Sanz F., Pastor M. Application of multilevel multivariate data analysis in drug design. Integrated approach for the multireceptorial design of antipsychotic agents. XXth International Symposium on Medicinal Chemistry. August 31–September 4, 2008. Vienna, Austria

Varela MJ., Brea J., Caruncho HJ., Cadavid MI., Loza MI. Characterisation of D2 dopamine receptors in synaptosomes of reeler mice. Poster. 30 Congreso Nacional de la Sociedad Española de Farmacología. 17-19 September 2008. Bilbao, Spain.

Villalba K., Aranda R., Masaguer CF., Areias FM., Loza MI. Synthesis, binding affinity and SAR of new benzofuranone derivatives as potential antipsychotics. Poster. 1.º Encontro Nacional de Química Terapéutica. 13-15 November 2008. Porto, Portugal.

Carro L., Alvarado M., Masaguer CF., Raviña E., Brea J., Loza, MI. Synthesis and Binding Affinity of New Quinazolinone Derivatives as Potential Atypical Antipsychotics. Poster. European Colloquium on Heterocycles Chemistry. 9-13 September 2008. Antwerp, Belgium.

Ferrandon S., Castro M., Okasaki M., Potts JT., Gardella TJ., Vilardaga J. Fluorescence resonance energy transfer analysis reveals selective binding of long- and short-acting PTH(1-28) analogs to distinct PTH receptor conformations. Poster. 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 2007. Hawaii, USA.

Gutiérrez-de-Terán H., Brea JM., Loza MI. Pharmacological profiling using HTS: Design and analysis of HTS campaigns. High Content Analysis Conference. 26-27 March 2007. Madrid, Spain.

Brea J., Giraldo J., Quintian F., Castro MA., Domínguez E., Cadavid MI., Loza MI. Differential regulation by antagonists of 5-HT2A receptors functional states. Putative role of homodimerization. Oral Communication. 29 Congreso Nacional de la Sociedad Española de Farmacología. 17-19 September 2007. Alcalá de Henares, Spain.

Quintián F., Varela M., Brea J., Cadavid MI., Loza MI. Enviroment influence on the conformational distribution of human and murine 5-HT2A receptors. Poster. 29 Congreso Nacional de la Sociedad Española de Farmacología. 17-19 September 2007, Alcalá de Henares, Spain.

Varela MJ, Quintián J., Brea J., Caruncho HJ., Cadavid MI., Loza MI. Characterization of D2 dopamine receptors in synaptosomes of swiss and reelin deficient (reeler) mice. Poster. 29 Congreso Nacional de la Sociedad Española de Farmacología. 17-19 September 2007. Alcalá de Henares, Spain.

Domínguez E., Castro M., Brea JM., Costas X., Carracedo A., Loza MI. The efficacy of antipsychotic drugs at neurotransmitter receptors is influenced by non-synonymous SNP: preliminar results for S421F at human serotonin 5-HT2A receptors. Oral Communication. III Congreso de la Sociedad española de Farmacogenética y Farmacogenómica. 15-17 November 2007. Santiago de Compostela, Spain.

Padín JF., Brea J., Redondo M., Dominguez E., Castro M., Cadavid MI. Pharmacological evidence for different conformational states at h-HT2A receptors in human blood platelets. Poster. 28 Congreso de la Sociedad Española de Farmacología. 19-22 September 2006. Santiago de Compostela, Spain.

Fernández Barge A., Domínguez E., Castro M., Dopeso-Reyes I., Paz E., Páramo M., Brenlla J., Agra S., Caruncho H., Loza MI. Análisis de los niveles de reelina en plasma de pacientes esquizofrénicos. Poster. II Jornadas para Jóvenes Investigadores en Neurociencia. Programa Interuniversitario de Neurociencia. 20 July 2006. Vigo, Spain.

Padín JF., Redondo M., Brea J., Domínguez E., Castro M., Loza MI. Effector pathway dependent activation elicited by 5-HT at human platelet 5-HT2A receptor. Poster. 28 Congress of the Spanish Society of Pharmacology. 19-22 September 2006. Santiago de Compostela, Spain.

Brea J., Quintián F., Fernández-Masaguer C., Pastor M., Sanz F., Loza MI. Butyrophenone derivatives as new leads for the development of atypical antipsychotic drugs. Multivariate analysis of their multitarget affinity profile. Poster. 28 Congress of the Spanish Society of Pharmacology. 19-22 September 2006. Santiago de Compostela, Spain.

Fernández Barge A., Castro M., Domínguez E., Dopeso-Reyes I., Paz E., Caruncho H., Loza MI. Analysis of reelin plasma levels as a peripheral biomarker in schizophrenia. Poster. 28 Congress of the Spanish Society of Pharmacology. 19-22 September 2006. Santiago de Compostela, Spain.

Domínguez E., Costas J., Cadavid MI., Brenlla J., Carracedo A., Loza MI. Extensive linkage disequilibrium mapping at the DRD3 gene in schizophrenia. Oral Communication. 28 Congress of the Spanish Society of Pharmacology. 19-22 September 2006. Santiago de Compostela, Spain.

Lozano MV., Brea J., Loza MI., Torres D., Alonso MJ. Cytotoxicity studies of chitosan oligomer nanocapsules containing docetaxel. VII Spanish-Portuguese Conference on Controlled Drug Delivery. October 2006. Pamplona, Spain.

Domínguez E., Padín F., Costas J., Agra S., Castro M., Brea J., Caruncho H., Carracedo A., Loza MI. Analysis of HTR2A gene and 5-HT2A protein in schizophrenia. Annual Meeting of Society for Neuroscience 2006. 14-18 October 2006. Atlanta, USA

Caruncho HJ., Sueiro C., Dopeso-Reyes IG., Loza MI., Rodríguez-Moldes I. Neurochemical alterations in the anterior cingulate cortex in psychiatric disorders. Annual Meeting of Society for Neuroscience 2006. 14-18 October 2006. Atlanta, USA

Zhubi A., Caruncho H., Loza MI., Guidotti A., Costa E. Peripheral blood lymphocytes (PBL) as probes to study altered epigenetic mechanism in schizophrenia. Annual Meeting of Society for Neuroscience 2006. 14-18 October 2006. Atlanta, USA

Castro M., Domínguez E., Padín JF., Buceta M., Álvarez V., Paz E., Brenlla J., Páramo M., Bonis J., Sanz F., Cadavid MI., Carracedo A., Loza MI. Biomarcadores proteicos en esquizofrenia: análisis de la expresión del receptor de dopamina D3 periférico. Poster. 1er Congreso Nacional sobre Farmacogenética y Farmacogenómica. 23-25 January 2005, Valencia, Spain.

González-Louro L, Otero JM, Castro MA, Sussman F, Villaverde MC, Estévez JC, Estévez RJ. Búsqueda de isómeros ópticos para inhibidores de la beta-secretasa. Poster. XXX Reunión Bienal de la Real Sociedad Española de Química. 19-23 September 2005, Lugo, Spain.

Castro M, Lohse MJ, Vilardaga J-P. Recording millisecond kinetics of peptide binding to a class B G protein-coupled receptor by fluorescence resonance energy transfer. Poster. 27 Congreso de la Sociedad Española de Farmacología. 3-4 October 2005, Sevilla, Spain.

Padín JF, Redondo M, Domínguez E, Quintián F, Brea JM, Castro M. Evidences for agonist-trafficking at 5-HT2A human receptors in a heterologous-expression cell system and in blood platelets. Poster. 27 Congreso de la Sociedad Española de Farmacología. 3-4 October 2005, Sevilla, Spain.

Quintián F., Brea JM., Masaguer CF., Castro M., Cadavid MI., Loza MI. Different negrees of constitutive activity in the pharmacology of the 5-HT2C serotonin receptor. Poster. 27 Congress of the Spanish Society of Pharmacology. 27-30 September 2005. Girona, Spain.

Domínguez E., Padín F., Cabrera J., Paz E., Páramo M., Castro M. Platelet 5-HT2A receptor density in schizophrenic patients. A biomarker in schizophrenia?. Poster. 27 Congress of the Spanish Society of Pharmacology. 27-30 September 2005. Girona, Spain.

Panjehpour M, Castro M, Klotz KN. The human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors. Oral Communication. 46st Spring Meeting de la Sociedad Alemana de Farmacología y Toxicología Experimental y Clínica. 2005. Mainz, Germany.

Brea J., Quintian F., Raviña E., Cadavid MI., Loza MI. Are different 5-HT2A conformations mediating the same signalling pathway?. Poster. 4th Congress of the Federation of the European Pharmacological Societies (EPHAR). 14-17 July 2004. Porto, Portugal

Loza MI., Domínguez E., Padín JF., Álvarez V., Paz E., Brenlla J., Buceta M., Carracedo A., Cadavid MI. Platelet 5-HT2A receptors and chronic outcome in schizophrenia. Poster. 4th Congress of the Federation of the European Pharmacological Societies (EPHAR). 14-17 July 2004. Porto, Portugal

Padín JF., Domínguez E., Buceta M., Rodríguez MA., Álvarez VJ., Cadavid MI., Caruncho H., Loza MI. Regulation induced by olanzapine in central nervous system (CNS) and blood cells on 5-HT2A and D3 receptors. Poster. 4th Congress of the Federation of the European Pharmacological Societies (EPHAR). 14-17 July 2004. Porto, Portugal

Carotti A., Cadavid MI., Centeno NB., Esteve C., Fontaine F., Gutiérrez de Terán H., Loza MI., Martínez A., Nicoletti O., Nieto R., Pastor M., Raviña E., Sanz F., Segarra V., Sotelo E., Stefanachi A., Vidal B. 9-Deazaxanthines as selective A2B AR ligands: design, synthesis and SAFIR studies. Poster. XVIIIth International Symposium on Medicinal Chemestry. 15-19 August 2004. Copenhagen, Denmark & Malmö, Sweden

Raviña E, Masaguer CF, Brea J, Loza MI. Conformationally constrained azabutyrophenones as potencial atypical antipsychotics. Poster. XVIIIth International Symposium on Medicinal Chemestry. 15-19 August 2004. Copenhagen, Denmark & Malmö, Sweden

Loza MI. The present state of collaboration between University and Industry, and incubator for star-up?. Oral Communication. XXVI Congress of the Spanish Society of Pharmacology. 26-29 September 2004. Salamanca, Spain.

Quintian F., Brea J., Masaguer CF., Raviña E., Loza MI., Cadavid MI. New tools with structural and pharmacological homology useful for defining functional conformational populations of 5-HT2C and 5-HT2A receptor. Poster. XXVI Congress of the Spanish Society of Pharmacology. 26-29 September 2004. Salamanca, Spain.

Padín JF., Iglesias R., Domínguez E., Brea JM., Cadavid MI., Loza MI. 5-HT2A signal transduction pathways in human platelets. Poster. XXVI Congress of the Spanish Society of Pharmacology. 26-29 September 2004. Salamanca, Spain.

Domínguez E., Padín F., Álvarez V., Paz E., Brenlla J., Paramo M., Cadavid MI., Carracedo A., Loza MI. Platelet 5-HT2A receptor density in long evolution schizophrenic patients. Oral Communication. XXVI Congress of the Spanish Society of Pharmacology. 26-29 September 2004. Salamanca, Spain.

Brenlla J., Paz E., Paramo M., Domínguez E., Padín F., Carracedo A., Loza MI., Cadavid MI., Álvarez V. Estudio de receptores 5-HT2A en plaquetas de pacientes esquizofrénicos. Poster. VIII Congreso Nacional de Psiquiatría. 26-30 October 2004. Bilbao, Spain.

Bunemann M, Vilardaga JP, Castro M, Krasel C, Lohse MJ. Optical recording of G-protein coupled receptor activation in intact cells. Oral Communication. 44st Spring Meeting de la Sociedad Alemana de Farmacología y Toxicología Experimental y Clínica. 2003. Mainz, Germany.

Loza MI. Interrogantes a la bioinformática desde la farmacología experimental. IV Jornadas de Bioinformática. 13-15 September 2003. A Coruña, Spain.

Padín JF., Buceta M., Rodríguez MA., Brea J., Quintián F., Domínguez E., Dopeso-Reyes IG., Domínguez F., Caruncho HJ., Cadavid MI., Loza MI. Comparative study of the regulation produced by olanzapine in 5-HT2A, D3 central and perifheral sites. Poster. Epigenetic Mechanisms, Gabaergic Neurotransmission, Reelin and Psychosis. 13-15 June 2003. Santiago de Compostela, Spain.

Rodríguez MA., Padín JF., Dopeso-Reyes IG., Buceta M., Domínguez E, Loza MI, Caruncho HJ. Variaciones en la expresión del receptor de serotonina 2A(5HT2A), receptor de dopamina 3(RD3), y reelina en áreas neocorticales de ratas tratadas con olanzapina. Poster. X Congreso de la Sociedad Española de Neurociencia. 6-9 September 2003. Lleida, Spain.

Quintián F, Brea J, Masaguer CF, Raviña E, Cadavid MI, Loza MI. Nuevos agonistas inversos del receptor 5-HT2C con posible actividad antipsicótica atípica. Poster. Congreso de la Sociedad Española de Farmacología. 8-11 October 2003. Cádiz, Spain.

Domínguez E., Padín JF., Buceta M., Rodríguez MA., Loza MI., Cadavid MI. Estudio comparativa de la regulación de los receptores 5-HT2A y D3 centrales y periféricos por la olanzapina. Poster. Congreso de la Sociedad Española de Farmacología. 8-11 October 2003. Cádiz, Spain.

Brea J., Quintian F., Masaguer CF., Raviña E., Cadavid MI., Loza MI. Nuevas herramientas farmacológicas para el estudio de estados conformacionales del receptor 5-HT2A. Oral Communication. Congreso de la Sociedad Española de Farmacología. 8-11 October 2003. Cádiz, Spain.

Castro M., Lohse MJ., Quitterer U. The subcellular localization affects the Gßgamma regulatory function of phosducin. Poster. 44st Spring Meeting de la Sociedad Alemana de Farmacología y Toxicología Experimental y Clínica. 2003. Mainz, Germany.

Pastor M., Benedetti P., Carotti A., Carrieri A., Díaz C., Herráiz C., Höltje HD., Loza MI., Oprea T., Padín F., Pubill F., Sanz F., Stoll F., and the LINK3D Consortium. Distant collaboration in drug discovery: The LINK3D project. Drugs Future 2002. Oral Communication. XVIIth International Symposium on Medicinal Chemistry. 1-5 September 2002.Barcelona, Spain.

González D., Padín JF., Buceta M., Brea J., Cano E., Loza MI. Affinities of clozapine and haloperidol for [3H]ketanserin-binding receptors in human and rat platelets and rat frontal cortex. Poster. XXIV Congress of the Spanish Society of Pharmacology. 22-25 September 2002. Toledo, Spain.

Brea J., Villazón M., Cadavid MI., Loza MI. Effector-related differences in the affinity of 5-HT2A for several antagonists. Poster. XXIV Congress of the Spanish Society of Pharmacology. 22-25 September 2002. Toledo, Spain

Raviña E., Masaguer CF., Loza MI., Cadavid MI., Brea J., Dezi C., Pastor M., Sanz F. Conformationally constrained aminobutyrophenones as new 5-HT2 ligands. Synthesis, molecular modelling and assays as antagonists and inverse agonists. Oral Communication. XVIIth International Symposium on Medicinal Chemistry. 1-5 September 2002. Barcelona, Spain.

Alvarado M, Fdez-Masaguer C, Raviña E, Brea J, Cadavid MI, Demontis GC. Valerofenonas conformacionalmente restringidas como antagonistas de receptores de dopamina y serotonina. Poster XII Congreso Nacional de la Sociedad Española de Química Terapéutica. 11-14 September 2001. Sevilla, Spain.

Loza MI. La Comunicación con el paciente y la automedicación. II Congreso Nacional de Atención Farmacéutica. 15-17 November 2001. Barcelona, Spain.

Caro Y., Torrado M., Fdez-Masaguer C., Raviña E., Brea J., Loza MI., Demontis GC. Síntesis enantioselectiva de 3-aminometiltetralona y su evaluación como potenciales agentes antipsicóticos atípicos. Poster. XII Congreso Nacional de la Sociedad Española de Química Terapéutica. 11-14 September 2001. Sevilla, Spain.

Pita B., Fdez-Masaguer C., Raviña E., Brea J., Loza MI., Demonis GC. Butirofenonas conformacionalmente restringidas en la serie de la piridina como agentes antipsicóticos potenciales. Poster. XII Congreso Nacional de la Sociedad Española de Química Terapéutica. 11-14 September 2001. Sevilla, Spain

Loza MI. Formación de postgrado para farmacéuticos. III Congreso Nacional de Informática y Farmacia. 21-22 November 2001. Barcelona, Spain.

Castro M., Krasel C., Dicker F., Vilardaga J-P., Lohse MJ. Role of PKC in the regulation of parathyroid hormone receptor signaling Poster. 41st Spring Meeting de la Sociedad Alemana de Farmacología y Toxicología Experimental y Clínica 2003. Mainz, Germany.

Honrubia M., Tristán H., Villazón M., Cadavid I., Loza MI., Beleta J., Díaz JL., Palacios JM. Comparison of the specific binding of the adenosine A2A receptor antagonist 3H-ZM-241385 and of the agonist 3H-CGS-21680 to bovine and human A2A receptors. Poster. Purines 2000: Biochemical, Pharmacological and Clinical Perspectives. 9-13 July 2000. Madrid, Spain.

Tristán H., Honrubia M., Villazón M., Cadavid I., Loza MI., Díaz JL., Palacios JM. Pharmacological and kinetic characterisation of NECA-induced A2B receptor-mediated response in isolated guinea-pig aorta. Poster. Purines 2000: Biochemical, Pharmacological and Clinical Perspectives. 9-13 July 2000. Madrid, Spain.

Cadavid M., Loza MI., Cordero L., Fernández-Llimós F. The TESEMED applications for pharmacy professionals. The community pharmacists and the responsible self-medication. II INFOPHARMA Workshop. Promoting Telematics for Responsible Self-Medication in Latin American Pharmacies. 20-21 May 2000. Helsinki, Finland

Cordero L, Loza MI, Fernández-Llimós F, Cadavid M. The TESEMED applications for pharmacy professionals. Protocols for minor ailments. II INFOPHARMA Workshop. Promoting Telematics for Responsible Self-Medication in Latin American Pharmacies. 20-21 May 2000. Helsinki, Finland

Loza MI., Fernández-Llimós F., Cadavid M., Cordero L. Testing results of the applications for pharmacy professionals. II INFOPHARMA Workshop. Promoting Telematics for Responsible Self-Medication in Latin American Pharmacies. 20-21 May 2000. Helsinki, Finland

Cadavid MI., Padín JF., Villazón M., Tristán H., Enguix M., Loza MI. Influence of endothelium in functional response to 5-HT in rat isolated aorta. Oral Communication. XXIII Congress of the Spanish Society of Pharmacology. 24-27 September 2000. Alicante, Spain.

Loza MI., Brea J., Villazón M., Cano E., Martínez S., Orallo F, Cadavid MI. Agonism and antagonism at 5-HT2A and 5-HT2C receptors measuring simultaneously IP accumulation and arachidonic acid release. Poster. XXIII Congress of the Spanish Society of Pharmacology. 24-27 September 2000. Alicante, Spain.

Enguix MJ., Sánchez L., Brea J., Villazón M., Cadavid MI., Loza MI. Ex vivo studies of regulation of peripheral 5-HT2 receptors. Poster. XXIII Congress of the Spanish Society of Pharmacology. 24-27 September 2000. Alicante, Spain.

Loza MI., Cordero L., Cadavid M., Fernández-Llimós F. TESEMED Pharmacists Training Programs. III INFOPHARMA Workshop. Assesment of Information Systems in Community Pharmacies for Responsible Self-Medication. 16-17 October 2000. Santiago de Compostela, Spain.

BOOK CHAPTERS

Sara Marsango; María José Varela Liste; Graeme Milligan. Approaches to Characterize and Quantify Oligomerization of GPCRs. Methods Molecular Biology. 1335, pp. 95 - 105. Human Press, 2015. DOI: 10.1007/978-1-4939-2914-6_7.

Parguiña AF, García A. Microparticle and exosome proteomic analysis. In: P. Harrison, I. Sargent, C. Gardiner (Eds). Extracellular vesicles in health and disease. Pan Stanford Publishing. 2014; pp. 285-315. DOI: 10.1201/b15647.

Jacoby, E., Azzaoui, K., Senger, S., Cuadrado Rodríguez, E., Loza, M.,Zdrazil, B., Pinto, M., Williams, A.J., de la Torre, V., Mestres, J.,Taboureau, O., Rarey, M., Chichester, C., Blomberg, N., Harland, L.,Ecker, G.F. Scientific requirements for the next generation semantic web-based chemogenomics and systems chemical biology molecular information system OPS. Ed. Computational Chemogenomics, Pan Stanford Publishing. 2013. pp. 213-242. DOI: 10.1201/b15631.

Brea J., Loza MI. New approaches applied to drug screening. En: Botana LM., Loza M., editores. Therapeutic targets: modulation, inhibition and activation.John Wiley & Sons, Inc. New Jersey 2012, p. 455-476. DOI: 10.1002/9781118185537.ch14.

Botana LM, Loza M, editores. Therapeutic targets: modulation, inhibition and activation. John Wiley & Sons, Inc. New Jersey 2012. DOI: 10.1002/9781118185537

Domínguez, E. Lipids as New Targets, in Therapeutic Targets: Modulation, Inhibition, and Activation. John Wiley & Sons. 2012. DOI: 10.1002/9781118185537.ch7

García A. Two-dimensional gel electrophoresis: basic principles and application to platelet signaling studies. In: García A, Senis YA (eds). Platelet proteomics: Principles, analysis and applications. John Wiley & Sons. 2011. pp. 89-110. DOI: 10.1002/9780470940297.ch4

Nieto A, Brea J, Cadavid MI, Mestres J, Sánchez-Sellero I, Gallego R, Fraga M, Loza MI. Allosteric modulation of 5-HT2B receptors by celecoxib and valdecoxib. Putative involvement in cardiotoxicity. En: Loza MI, López V, Martín F, Pazos, A eds. Advances in biomedical informatics: COMBIOMED. A Coruña, 2011. p. 67-79. In Press.

Algorta J, Loza MI, Luque A, coordinadores. Reflexiones sobre la formación en investigación y desarrollo de medicamentos. Cuadernos de la Fundación Dr. Antonio Esteve nº 10. Barcelona: Prous Science SA; 2007. p. 159-161. In Press.

García A, Senis Y, Tomlinson MG, Watson SP. Platelet genomics and proteomics. In: Michelson AD editor. Platelets (second edition). Elsevier/Academic Press. 2007. pp. 99-116. DOI: 10.1172/JCI26885.

Loza MI, Cordero L, Cadavid MI, Faba G, Sanz F. El autoconsumo de medicamentos. En: Baños JE, Bigorra J editores. La proyección social del medicamento. Monografías Dr. Atonio Esteve. Fundación Dr. Atonio Esteve, 2007. p. 41-49. ISBN: 978-84-935465-6-4. In Press.

García A. Two-dimensional gel electrophoresis in platelet proteomics research. Vascular biology protocols. Volume included in the series "Methods in molecular medicine". Humana Press. 2007. pp. 339-354. In Press.

Cadavid MI, Loza MI. Tratamiento de la tos. En: Lopez A, Moreno L, Villagrasa V editores. Manual de Farmacología. Guía para el uso racional del medicamento. 2006. p. 132-142. In Press.

Bonis J, Loza MI. Sanz F. La bioinformática como soporte a las nuevas estratégias farmacogenéticas y farmacogenómicas. Informática Biomédica. 2004. p. 247-258. In Press.

García-Alonso A , Alvarez CV, Villapol S, Canibano C, Diéguez C. Regulation of Pit-1 expression by ghrelin and GHRP-6. In: Tamburrano G, Casanueva FF, Baldelli R, eds. Update in neuroendocrinology: from basic research to clinical practice. Pubblicazioni Medico Scientifiche – Udine.z/ pp. 18-38. In Press

Loza MI, Echarri E, Cadavid MI, Cordero L, Sanz F. Sistema de Información farmacéutica. Manual de Informática Médica. 2003. p. 401-413. In Press.

Loza MI, Mengod G, Cadavid MI. Autacaides I. Histamina y antihistamínicos. Serotonina y antiserotonímicos. Farmacología Fundamental. 2003. p. 141-166. In Press.

García-Alonso A , Álvarez CV, Villapol S, Canibano C, Diéguez C. Regulation of Pit-1 expression by ghrelin and GHRP-6. In: Tamburrano G, Casanueva FF, Baldelli R, eds. Update in neuroendocrinology: from basic research to clinical practice. Pubblicazioni Medico Scientifiche – Udine. pp. 18-38. DOI: 10.1210/mend.15.9.0694. In Press.

PHD TESIS

Title: Utilización inapropiada de medicamentos en pacientes ancianos polimedicados en atención primaria. Factores determinantes e intervención del farmacéutico.
Author: Jesús Martínez Sotelo.
Directors: Mª Isabel Cadavid Torres.

Title: Development of ligands for the platelet receptor CLEC-2.
Author: Luis Arturo Morán Lara.
Directors: Angel García Alonso.

Title: Impacto y aplicación del secretoma de las plaquetas en medicina transfusional.
Author: Lidia Hermida Nogueira.
Directors: Angel García Alonso.

Title: Estudio del efecto de la oligomerización sobre la selectividad funcional de receptores acoplados a proteínas g. Aplicación a la farmacología de la esquizofrenia.
Author: Laura Gómez García.
Directors: Mª Isabel Loza García and José Manuel Brea Floriani.

Title: Identificación de nuevos ligandos dirigidos a la interleuquina 17 con utilidad farmacológica en enfermedades autoinmunes.
Author: Elia Álvarez Coiradas.
Directors: Mª Isabel Loza García and Eduardo Domínguez Medina.

Title: Estudio de la influencia de los puentes disulfuro extracelulares del receptor 5-HT2A homodimérico en la farmacología antipsicótica.
Author: Marta Cimadevila Fondevila.
Directors: Mª Isabel Loza García and Jose Manuel Brea Floriani.

Title: Impacto de la obesidad en la reactividad de las plaquetas y su relación con la enfermedad coronaria.
Author: María Núñez Barrachina.
Directors: Ángel García and María Pardo Pérez.

Title:Estudios de señalización e inhibición de receptores ITAM en plaquetas: búsqueda de nuevos antiagregantes plaquetarios.
Author: Irene Izquierdo Berjano.
Directors: Ángel García.

Title:Estudio de aspectos emergentes en la farmacología de receptores acoplados a proteínas G relevantes en esquizofrenia: alosterismo, selectividad funcional y compartimentación de la señalización.
Author: Andrea García.
Directors: Mª Isabel Loza García and Marián Castro.

Title:Estudio de homodímeros del receptor 5-HT2A de serotonina y sus mecanismos de activación en la farmacología de la esquizofrenia.
Author: Alba Iglesias.
Directors: Mª Isabel Loza García and Jose Manuel Brea Floriani.

Title:Identificación de nuevos compuestos activos en el receptor GPR35. Un receptor huérfano implicado en procesos inflamatorios.
Author: Alejandro González.
Directors: Mª Isabel Loza García and Jose Manuel Brea Floriani.

Title:Desarrollo de modelos in vitro de dolor y su aplicación al cribado de alto rendemiento.
Author: Antón Leandro Martínez.
Directors: Mª Isabel Loza García y Javier Burgueño.

Title:Estudio In Vitro de la influencia del heterodímero de los receptores D2 de Dopamina y 5-HT2A de Serotonina. Aplicación a la Farmacoterapia Antipsicópita.
Author: Sonia Gómez Fernández.
Directors: Mª Isabel Loza García and Jose Manuel Brea Floriani.

Title:Estrategias multicomponente en el descubrimiento de derivados Heterocíclicos Antagonistas de los receptores de Adenosina/Inhibidores de Fosfodiesterasas.
Author: Cristina Val García.
Directors: Mª Isabel Loza García and Eddy Sotelo.

Title: Estudio del impacto de la dimerización y de variantes polimórficas en la farmacología y función de receptores acoplados a prote ínas G (GPCRs) relevantes en esquizofrenia.
Author: Rocío Ailim de la Fuente Rodríguez.
Directors: Mª Isabel Loza García and Marián Castro Pérez.

Title: Estudio de la influencia de la reelina sobre receptores acoplados a proteínas G relacionadas con la farmacología de la esquizofreni.
Author: Sonia Lage Abad.
Directors: Mª Isabel Loza García and Jose Manuel Brea Floriani.

Title: Aspectos estructurales y cinéticos de la interacción ligando-receptor relevantes en la farmacología de la esquizofrenia.
Author: Javier Rodríguez Carracedo.
Directors: Mª Isabel Loza García and Mª de los Angeles Castro Perez.

Title: Estudio farmacológico de la modulación del receptor 5-HT2B de serotonina por inhibidores selectivos de la COX-2 (celecoxib y valdecoxib) y fluoxetina.
Author: Ainhoa Nieto Gutiérrez.
Directors: María Isabel Loza García, Jose Manuel Brea Floriani, Inés Sánchez Sellero.

Title: Estudio de la funcionalidad de GPCRs mediante el uso de herramientas biológicas y químicas: aplicación a los recptores 5-HT2A y 5-HT7 de serotonina.
Author: Patricio Atanes Juiz.
Directors: María Isabel Loza García, Maria de los Ángeles Castro Pérez.

Title:Deseño, implantación e análise de un modelo para a xestión do seguemento farmacoterapéutico nunha farmacia comunitaria. Author: Belen Cobian.
Directors: Jose Manuel Brea Floriani, María Isabel Loza García.

Title: Estudio del ratón heterocigoto reeler como modelo animal in vitro de la esquizofrenia. Caracterización farmacológica de los receptores D₂ y 5-HT_2A.
Author: María José Varela Liste.
Directors: Mª Isabel Loza García, Jose Manuel Brea Floriani.

Title: Study of the expression and functional mechanisms of the extracellular matrix protein, reelin, during prenatal development of the rodent brain.
Author: Iria González-Dopeso Reyes.
Directors: Hector Caruncho Michinel , Miguel Angel Rodríguez.

Title: Análisis comparativo de la interacción ligando-receptor entre sistemas nativos y recombinantes: comportamiento conformacional de GPCRs.
Author: Juan Fernando Padín Nogueira.
Directors: Mª Isabel Loza García, Mª Isabel Cadavid Torres.

Title: Estudio de la variabilidad genética y de la expresión de los receptores 5-HT2A de serotonina y D3 de dopamina como biomarcadores candidatos en la esquizofrenia.
Author: Eduardo Domínguez Medina.
Directors: Mª Isabel Loza García, Ángel Carracedo Álvarez.

Title: Estudio de la señalización intracelular y la regulación de los receptores 5-HT2 de serotonina. Evaluación diferencial para antipsicóticos. Thesis.
Author: José Manuel Brea Floriani.
Directors: Mª Isabel Loza García, Mª Isabel Cadavid Torres

Title: Regulación farmacológica de receptores acoplados a proteínas G: aplicación a receptores 5-HT2A, 5-HT2B y A2B.
Author: María Villazón González.
Facultad de Farmacia, Universidad de Santiago de Compostela.
Directors: Mª Isabel Loza García, Mª Isabel Cadavid Torres

REVIEWS

Brea J, Castro-Palomino J, Yeste S, Cubero E, Párraga A, Domínguez E, Loza MI. Emerging opportunities and concerns for drug discovery at serotonin 5-HT2B receptors. Curr Top Med Chem. 2010;10(5):493-503. In Press.

Caruncho HJ, Dopeso-Reyes IG, Loza MI, Rodriguez MA. GABA, reelin and the neurodevelopmental hypothesis of schizophrenia. Crit Rev Neurobiol 2004; 16: 25-32.

Caruncho HJ. Book review: “GABA in the nervous system: the view at 50 Years”. Journal of Chemical Neuroanatomy 2003; 24: 77.

Caruncho HJ. Book review: “ Biological Psychiatry” by M.R. Trimble. John Wiley and Sons. Journal of Chemical Neuroanatomy 2002;23:231.

BOOK EDITIONS

Luis M. Botana / Mabel Loza.
Therapeutic Targets. Modulation, Inhibition, and Activation.
Wiley & Sons, USA.

Ángel García, Yotis A Senis (eds).
Platelet proteomics: Principles, analysis and applications.
Wiley & Sons, USA

Brea J, Cadavid MI.
Manual de Farmacoterapia
Universidade de Santiago de Compostela