New CiQUS advance in the field of asymmetric catalysis through a novel synthetic methodology for the stereoselective preparation of highly functional chiral molecules

• The study has been published in the prestigious scientific journal Angewandte Chemie and has been featured as a Hot Article and Frontispiece.

The article "Enantio- and Diastereoselective Copper-Catalyzed Allylboration of Alkynes with Allylic gem-Dichlorides" of the Sustainable Catalysis and Asymmetric Synthesis group of CiQUS principal investigator Martín Fañanás has just been published recently in the scientific journal Angewandte Chemie International Edition. 

Hot Article and Frontispiece
The article, which describes a new synthetic methodology for the stereoselective preparation of highly functional chiral molecules, has been highlighted as a Hot Article and, in addition, as a Frontispiece cover of the journal.

Singular methodology 

This work describes a novel synthetic methodology that allows the construction of chiral skipped dienes with multiple stereochemical elements in a single operation. The high degree of functionalization and the excellent control of the stereoselectivity make these molecules highly versatile optically active building blocks for asymmetric synthesis.

This study reveals the key use of a chiral NHC ligand capable of establishing a supramolecular cation bridge ligand-substrate interaction which is key for the control of the stereochemistry.

Reference: Andrea Chaves-Pouso,Andrés M. Álvarez-Constantino,Prof. Martín Fañanás-Mastral; Enantio- and Diastereoselective 
Copper-Catalyzed Allylboration of Alkynes with Allylic gem-Dichlorides; Angew. Chem. Int. Ed. 2022, 61, e202117696. 
http://doi.org/10.1002/anie.202117696