18/07/2014
A paper from ComBioMed group (leaded by prof. Eddy Sotelo) is the fourth most downloaded article from ACS Combinatorial Science web for two consecutive months.
The paper documents a multicomponent-based quinoxaline synthesis; thus enabling the rapid assembly of quinoxaline frameworks present in natural products and drugs.
This convergent and versatile method uses readily available commercial reagents, does not require advanced intermediates, and exhibits excellent bond-forming efficiency, thus exemplifying the operationally simple synthesis of quinoxaline libraries.Research paper: Ugi-Based Approaches to Quinoxaline Libraries