02/05/2012
A recent article by Concepción González-Bello and co-workers, in collaboration with researchers at University of Newcastle upon Tyne, has been selected as inside front cover of Organic & Biomolecular Chemistry last issue. This work (Org. Biomol. Chem., 2012, 10, 3663-3676) describes the synthesis of several 3-alkylaryl mimics of the enol intermediate in the the reversible dehydration reaction of 3-dehydroquinic acid, which is catalysed by type II dehydroquinase, to investigate the effect on the inhibition potency of replacing the oxygen atom in the side chain by a carbon atom.