Synthesis and applications of new catalytic systems supported on polymeric matrices
Last Friday, PhD Student Paula Maria Diaz Martinez has defended her doctoral thesis entitled "Synthesis and applications of new catalytic systems supported on polymeric matrices", which has been supervised by CiQUS teachers Eddy Sotelo Pérez and Alberto Coelho Cotón, and which addresses the current importance of sustainable and clean chemical and propose alternative solutions to the classical drug synthesis.
This doctoral thesis is part of an overall project, developed by the Research Group COMBIOMED, designed to exploit the advantages of supported reagents in preliminary drug discovery. As part of this work (which has led to three high-impact publications in the area of catalysis) new copper-based catalyst systems supported on different polymeric matrices that have proven effective, recyclability and synthetic potential interest in different transformations including multicomponent reactions have been developed. Together, these catalysts are excellent tools for implementing high performance synthetic methodologies (High Throughput Synthesis).
Further, it has been developed a new catalytic system of nanometric dimensions consisting in an inorganic silica matrix nonfunctionalized, which encapsulates the copper by direct interaction with the matrix. Copper is fixed to the support nanoscale silica by physical entrapment. Here, the copper loading levels were studied to optimize the effective amount of copper trapped in the matrix. This trapping limits the diffusion of copper species to the solution while stabilizes, providing new heterogeneous catalysts for and Ullmann Huisgen reactions.
