Deep eutectic solvents for membrane transport of nucleic acids (DUNE)

A novel nucleic-acid membrane-transport system will foster innovation in nucleic acid therapeutics

The delivery of nucleic acids as therapeutic methods holds great potential to provide new treatments against emergent pathogens and important diseases. However, the development of functional therapies is often hindered by the poor efficiency and stability of the current transport technologies.

Deep eutectic solvents (DES) are non-aqueous sustainable liquids obtained through the combination of simple organic molecules. Overall, this project is aimed to discover a completely new range of potential applications of DES in membrane transport and biomolecular cargo preservation, which will open a new research field of potential applications in NA delivery.