Elucidating the nano-biointeractions on DNA origami (ORBIT)

Elucidating the nano-biointeractions on DNA origami (ORBIT)

The programmability of the DNA origamis allows the synthesis of predictable and controllable sizes and shapes with almost atomic precision. In addition, the origamis can also be designed to include additional molecules, with high accuracy on the valency and the orientation. Thus, this technology offers a powerful tool to study and understand the biological behaviour of objects at the nanoscale since precise control over the size, shape and attachment of molecules can be achieved when other methods are unable to.

Based on the structural organization and spatial distribution of natural and specific nanoparticles, such as viruses, this project will exploit the atomic programmability of origamis to design a library of DNA nanostructures inspired on viral particles, which allow us a better understanding of the biological response of the nanoscale object.