Engineered Exosomes for Stimuli-responsive Image-guided Drug delivery for Cancer Theranostic applications (TheranoXome)

Remote-controlled drug delivery

Cell membrane nanoparticles are biomimetic nanoparticles that are synthesized from endogenous materials derived from the body. Such biomimetic systems have the potential to unlock the true potential of nanomedicines for cancer therapy and diagnosis as they possess inherent characteristics including homotypic targeting, immune-cell evasion, high bio-availability and low toxicity.

In the present work, cell membrane nanoparticles will be used as delivery vehicles for stimuli-responsive nanoparticles and drugs in order to impart spatio-temporal control over drug release. Furthermore, co-loading of therapeutic and diagnostic nanoparticles will also be undertaken to develop a fully bio-active and bio-compatible theranostic nano-drug delivery system.